Wiley Series in Drug Discovery and Development
About The Wiley Series in Drug Discovery and Development
The Wiley Series in Drug Discovery & Development captures research topics of significant current interest and presents to the entire pharmaceutical community a distilled version of new developments in each topic area. This series encompasses all areas of drug discovery and development including the underlying pathophysiology of important diseases and disease vectors; therapeutic approaches to the treatment of various diseases; the properties of molecular targets for therapeutic agents; important new methodologies facilitating the search for therapies; genomics and proteomics; structure-activity correlations of drug series; the development of new imaging and diagnostic tools; drug metabolism; drug delivery; and chemical, pharmacological, pharmacokinetic, pharmacodynamic, and clinical characteristics of important drugs.
About the Editor-in-Chief
Dr. Binghe Wang is a medicinal chemist. He is currently Professor of Chemistry at Georgia State University, Georgia Research Alliance Eminent Scholar in Drug Discovery, and Georgia Cancer Coalition Distinguished Cancer Scholar. He is also Editor-in-Chief of Medicinal Research Reviews, one of the leading medicinal chemistry journals worldwide. He has published extensively in the field of medicinal, pharmaceutical, bioorganic, and organic chemistry.
Wiley Series in Drug Discovery and Development (22)
Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference.
• Helps readers understand progress in drug delivery research and applications
• Updates and expands coverage to reflect advances in materials Read More
This new edition overviews drug transporters and presents the principles of drug transport and associated techniques, featuring new chapters on multidrug and toxin extrusion proteins, placental transport, in silico approaches in drug discovery, and regulatory guidance for drug transport studies in drug development.
• Describes drug transporter families, mechanisms, and clinical implications along with experimental methods for studying and characterizing Read More
The opportunities and challenges of using dendrimers to improve drug delivery
Among pharmaceutical and biomedical researchers, the use of dendrimers in drug delivery systems has attracted increasing interest. In particular, researchers have noted that the volume of a dendrimer increases when it has a positive charge. If this property can be applied effectively, dendrimers have enormous potential in drug delivery systems, directly supplying medication Read More
An in-depth exploration of the applications of plant bioactive metabolites in drug research and development
Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectivesprovides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international Read More
A thorough, accessible, and general overview of chemosensors
Providing a comprehensive overview of chemosensorsorganic molecules designed to bind and sense small molecules or metal ionsand their applications, Chemosensors: Principles, Strategies, and Applications is an accessible one-stop resource for analysts, clinicians, and graduate students studying advanced chemistry and chemosensing.
Chemosensors function on a molecular level, generating a signal Read More
Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry—a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs Read More
Understand and assess the design, delivery, and efficacy of orally administered drugs
A practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help chemists, biologists, life science researchers, pharmaceutical scientists, pharmacologists, clinicians, and graduate and students become familiar with the Read More
Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation
It is believed that selecting the "right" drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early drug discovery to improve the assessment of potential drug compounds. Now, Evaluation of Drug Candidates Read More
Since the discovery of protein kinase activity in 1954, the field of protein kinase drug discovery has advanced dramatically. With the ongoing clinical success of the Bcr-Abl kinase inhibitor Gleevec in the treatment of chronic myelogenous leukemia and seven additional marketed kinase inhibitor drugs, researchers have compelling evidence that kinase inhibitors Read More
The second most abundant transition element in living organisms, zinc spans all areas of metabolism, with zinc-containing proteins offering both established and potential drug targets. Drug Design of Zinc-Enzyme Inhibitors brings together functional and structural information relevant to these zinc-containing targets. With up-to-date overviews Read More
ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to target and destroy such cells. In MDR, patients who are on medication eventually develop resistance to not only Read More
The relatively new field of glycoimmunology has emerged from the marriage of glycobiology and immunology, in recognition of the important role carbohydrates play as antigenic determinants. Carbohydrate-Based Vaccines and Immunotherapiescomprehensively reviews the state of this exciting field, offering a single source for both the fundamental science and the latest developments Read More
This book consolidates current information on the dopamine transporter (DAT) in relationto medicinal chemistry and synthesis, biology and pathology, and pharmacology. Because of DAT's role in diseases such as Parkinson's, schizophrenia, attention deficit hyperactivity disorder (ADHD), Tourette syndrome, and drug abuse Read More
The development of powerful expression cloning and genome analysis techniques has facilitated the molecular identification and characterization of numerous transporters that play a crucial role in drug disposition. Explaining the principles of drug transport and the associated techniques, Drug Transporters: Molecular Characterization Read More
During the last twenty years, there have been numerous advances in the understanding of the chemistry, biochemistry, and recognition of aminoglycosides. This has led to the development of novel antibiotics and opened up new therapeutic targets for intervention. This is the first book to provide a complete overview of recent advances in the field and explore their tremendous potential Read More