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October 24, 2016

New Book Hopping Over the Rabbit Hole Shows Entrepreneurs How to Pivot from Challenges, Setbacks and Failure to Achieve Success

Anthony Scaramucci’s third book gives business owners the skills, insights and mindset to succeed in a challenging business environment

October 24, 2016

Creeping Gel: Photosensitive self-oscillating gel to model biological crawling motions

Directed motion seems simple to us, but the coordinated interplay of complex processes is needed, even for seemingly simple crawling motions of worms or snails. By using a gel that periodically swells and shrinks, researchers developed a model for the waves of muscular contraction and relaxation involved in crawling. As reported in the journal Angewandte Chemie, they were able to produce two types of crawling motion by using inhomogeneous irradiation.

12:00 AM EDT October 24, 2016

Study Indicates that Advances in Precision Medicine Have Improved Breast Cancer Treatment

A new study examines how one early example of precision medicine—tumor genome testing—is being used in women with breast cancer to reduce overtreatment and maximize the benefits of chemotherapy. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the study found that physician recommendations and final treatment decisions correlated highly with test results, suggesting genome testing helped physicians identify which patients could most benefit from chemotherapy, and those for whom chemotherapy could be safely omitted. Additionally, these personalized recommendations appeared to eliminate racial/ethnic and educational disparities in testing or treatment; however, many women who were tested inaccurately recalled their test results.

October 24, 2016

Study Uncovers Brain Changes in Offending Pedophiles

New research reveals that certain alterations in the brain may be present in pedophiles, with differences between hands-on offenders and those who have not sexually offended against children. 

October 21, 2016

Where Does Cisplatin Bind?: Identification of genome-wide cisplatin cross-linking sites with DNA base resolution

Cisplatin is one of the most widely used agents in cancer chemotherapy. Its mode of action is cross-linking of the DNA, which can kill cells. But which part of the genome is more affected, and which is less affected? A Chinese team of scientists have now set up a universal, genome-wide assay system to detect the specific cisplatin action sites, In the journal Angewandte Chemie the scientists introduce their system and report initial results, which support the notion that the mitochondrial genome is one of cisplatin's main targets.

October 20, 2016

Wiley Celebrates the 2016 Nobel Prize Laureates

John Wiley & Sons, Inc., (NYSE: JWa, JWb) would like to acknowledge the laureates honored with the 2016 Nobel Prize. Six of these laureates have had their work published in Wiley’s medical, physiology, chemistry and economics journals and books.

October 20, 2016

Change Is Needed to Prevent Homicides by Individuals with Mental Illness

Following the stabbing death of Dr. Jeroen Ensink, a new father in London who was killed by a mentally ill man who had walked free after attacking a police officer with a knife days earlier, experts are calling for change. They note that the dangerousness of a small but volatile subset of psychiatric patients is not taken seriously enough. 

October 20, 2016

Self-Healable Battery: Lithium ion battery for electronic textiles grows back together after breaking

Electronics that can be embedded in clothing are a growing trend. However, power sources remain a problem. In the journal Angewandte Chemie, scientists have now introduced thin, flexible, lithium ion batteries with self-healing properties that can be safely worn on the body. Even after completely breaking apart, the battery can grow back together without significant impact on its electrochemical properties.

October 19, 2016

Hidden Chirality: Nitrogen-15 isotope can trigger asymmetric autocatalytic reactions toward chiral organic compounds

The preparation of chiral compounds as intermediates in drug synthesis is one of the most important targets in synthetic organic chemistry. Japanese scientists have now shown that the autocatalytic preparation of a chiral intermediate can be triggered by a compound bearing hidden chirality, which consisted of nothing more than the difference between the isotopes nitrogen-15 and nitrogen-14. The study is published in the journal Angewandte Chemie.

October 19, 2016

Research Reveals How Novel Osteoporosis Drug Increases Bone Mass

Abaloparatide, a selective activator of the parathyroid hormone receptor, has recently been shown to reduce fractures in postmenopausal women with osteoporosis. Now new research shows that abaloparatide increases bone mass in rats whose ovaries have been removed by stimulating bone formation, without effects on bone resorption.

October 14, 2016

Replacing Diet Beverages with Water May Help Diabetic Patients Lose Weight

In a study of 81 overweight and obese women with type 2 diabetes who usually consumed diet beverages and were on a weight loss program, those who substituted water for diet beverages after their lunch for 24 weeks had a greater decrease in weight (-6.40 vs. -5.25 kg) and body mass index (-2.49 vs. -2.06 kg/m2) compared with those who continued to consume diet beverages. 

October 13, 2016

Wiley ChemPlanner Awarded ALPSP Award for Innovation in Publishing

John Wiley & Sons, Inc., (NYSE: JWa, JWb) is pleased to announce that Wiley ChemPlanner was awarded the ALPSP Award for Innovation in Publishing, and presented at the Association of Learned & Professional Society Publishers (ALPSP) Conference in London. 

October 13, 2016

Bait Worms Are a Valuable Marine Resource

The humble bait worm wriggling on the hook at the end of angler’s line may be considered a low value resource, but in the first global assessment of its value and impact, researchers have revealed it to be a multi-billion pound global industry worth nearly £6 billion per year. 

October 13, 2016

Genetic Variants May Affect Breast Cancer Drug Concentrations and Patient Outcomes

In a study of 110 women taking the breast cancer drug anastrozole, there were significant differences in patients’ blood levels of the drug that corresponded with variations in the ABCB1 gene. Furthermore, variants in the CYP19A1 gene were associated with additional joint pain and cancer recurrence in patients.

October 13, 2016

Healthcare Workers Describe their Experiences in Caring for Patients with Ebola Virus Disease

Interviews conducted in 2015 with eight nurses and one physician who had worked in Ebola care in Sierra Leone revealed two themes: ‘Experiencing security by learning to manage risks’; and ‘Developing courage and growth by facing personal fears’. 

October 13, 2016

Starving Pancreatic Cancer Cells: Scientists Identify Potential Pancreatic Cancer Target

Researchers have found that a protein called SLC6A14 is overexpressed by several fold in pancreatic tumors taken from patients and in cancerous pancreatic cells lines compared with normal pancreatic tissue or normal pancreatic cells. SLC6A14 transports amino acids into cells to help with cellular metabolism.

October 13, 2016

Study Results May Help Patients after ACL Surgery

A new study provides critical information on how osteoarthritis may arise after anterior cruciate ligament (ACL) injury.

October 13, 2016

Understanding Why Potentially Inappropriate Medications Are Continued at the End of Life

A recent interview study has uncovered factors that may contribute to the use of potentially inappropriate medications (PIMs) at the end of life. 

October 11, 2016

Research Findings May Lead to Promising Zika Virus Drug Targets

Following recent outbreaks of Zika virus and the potential health dangers of infection, especially during pregnancy, scientists are striving to rapidly develop effective antiviral drugs that can halt transmission. Investigators who recently performed detailed analyses of the targets of a key enzyme of the Zika virus have uncovered peculiarities of the viral enzyme, called the NS3 protease.

October 11, 2016

Research Points to Ways to Improve the Therapeutic Potential of Stem Cells

Stem cells hold great promise for transforming medical care related to a diverse range of conditions, but the cells often lose some of their therapeutic potential when scientists try to grow and expand them in the laboratory. A new study, however, provides insights on the cellular mechanisms that might be targeted to help certain stem cells—called human mesenchymal stem cells (hMSCs)—maintain properties needed to make them clinically useful.