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New research reveals that certain alterations in the brain may be present in pedophiles, with differences between hands-on offenders and those who have not sexually offended against children.
Where Does Cisplatin Bind?: Identification of genome-wide cisplatin cross-linking sites with DNA base resolution
Cisplatin is one of the most widely used agents in cancer chemotherapy. Its mode of action is cross-linking of the DNA, which can kill cells. But which part of the genome is more affected, and which is less affected? A Chinese team of scientists have now set up a universal, genome-wide assay system to detect the specific cisplatin action sites, In the journal Angewandte Chemie the scientists introduce their system and report initial results, which support the notion that the mitochondrial genome is one of cisplatin's main targets.
John Wiley & Sons, Inc., (NYSE: JWa, JWb) would like to acknowledge the laureates honored with the 2016 Nobel Prize. Six of these laureates have had their work published in Wiley’s medical, physiology, chemistry and economics journals and books.
Following the stabbing death of Dr. Jeroen Ensink, a new father in London who was killed by a mentally ill man who had walked free after attacking a police officer with a knife days earlier, experts are calling for change. They note that the dangerousness of a small but volatile subset of psychiatric patients is not taken seriously enough.
Self-Healable Battery: Lithium ion battery for electronic textiles grows back together after breaking
Electronics that can be embedded in clothing are a growing trend. However, power sources remain a problem. In the journal Angewandte Chemie, scientists have now introduced thin, flexible, lithium ion batteries with self-healing properties that can be safely worn on the body. Even after completely breaking apart, the battery can grow back together without significant impact on its electrochemical properties.
Hidden Chirality: Nitrogen-15 isotope can trigger asymmetric autocatalytic reactions toward chiral organic compounds
The preparation of chiral compounds as intermediates in drug synthesis is one of the most important targets in synthetic organic chemistry. Japanese scientists have now shown that the autocatalytic preparation of a chiral intermediate can be triggered by a compound bearing hidden chirality, which consisted of nothing more than the difference between the isotopes nitrogen-15 and nitrogen-14. The study is published in the journal Angewandte Chemie.
Abaloparatide, a selective activator of the parathyroid hormone receptor, has recently been shown to reduce fractures in postmenopausal women with osteoporosis. Now new research shows that abaloparatide increases bone mass in rats whose ovaries have been removed by stimulating bone formation, without effects on bone resorption.
In a study of 81 overweight and obese women with type 2 diabetes who usually consumed diet beverages and were on a weight loss program, those who substituted water for diet beverages after their lunch for 24 weeks had a greater decrease in weight (-6.40 vs. -5.25 kg) and body mass index (-2.49 vs. -2.06 kg/m2) compared with those who continued to consume diet beverages.
The humble bait worm wriggling on the hook at the end of angler’s line may be considered a low value resource, but in the first global assessment of its value and impact, researchers have revealed it to be a multi-billion pound global industry worth nearly £6 billion per year.
In a study of 110 women taking the breast cancer drug anastrozole, there were significant differences in patients’ blood levels of the drug that corresponded with variations in the ABCB1 gene. Furthermore, variants in the CYP19A1 gene were associated with additional joint pain and cancer recurrence in patients.
Interviews conducted in 2015 with eight nurses and one physician who had worked in Ebola care in Sierra Leone revealed two themes: ‘Experiencing security by learning to manage risks’; and ‘Developing courage and growth by facing personal fears’.
Researchers have found that a protein called SLC6A14 is overexpressed by several fold in pancreatic tumors taken from patients and in cancerous pancreatic cells lines compared with normal pancreatic tissue or normal pancreatic cells. SLC6A14 transports amino acids into cells to help with cellular metabolism.
A new study provides critical information on how osteoarthritis may arise after anterior cruciate ligament (ACL) injury.
A recent interview study has uncovered factors that may contribute to the use of potentially inappropriate medications (PIMs) at the end of life.
Following recent outbreaks of Zika virus and the potential health dangers of infection, especially during pregnancy, scientists are striving to rapidly develop effective antiviral drugs that can halt transmission. Investigators who recently performed detailed analyses of the targets of a key enzyme of the Zika virus have uncovered peculiarities of the viral enzyme, called the NS3 protease.
Stem cells hold great promise for transforming medical care related to a diverse range of conditions, but the cells often lose some of their therapeutic potential when scientists try to grow and expand them in the laboratory. A new study, however, provides insights on the cellular mechanisms that might be targeted to help certain stem cells—called human mesenchymal stem cells (hMSCs)—maintain properties needed to make them clinically useful.
Catalyst from the Microwave: Microwave-assisted thermolysis: New route to highly crystalline carbon nitrides for efficient photocatalytic hydrogen generation
Lunch out of the microwave usually doesn’t taste nearly as good as a meal made in a conventional oven. This difference in quality is reversed for graphitic carbon nitride, a catalyst used for generating hydrogen from sunlight. Treatment of a precursor material with microwaves delivers a significantly more crystalline product than conventional thermolysis in an oven. As scientists report in the journal Angewandte Chemie, a catalyst produced in this way is significantly more effective in the generation of hydrogen.
A new study finds that the costs of breast cancer chemotherapy vary widely, even among treatment regimens with similar efficacy, and that patients bear a substantial out-of-pocket burden. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the study is the first to examine these cost differences, providing clinicians with accessible information to answer patient questions about their treatment options.
Although individuals often consume natural products because of their potential health benefits, a new review indicates that it is not clear whether the benefits of plant-derived compounds that mimic estrogen outweigh the possible health risks. The findings are published in the British Journal of Pharmacology.