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October 21, 2014

Preservation Technique for Marginal Livers Prevents Biliary Stricture

New research shows that a preservation technique known as sequential subnormothermic ex vivo liver perfusion (SNEVLP) prevents ischemic type biliary stricture following liver transplantation using grafts from donations after cardiac death (DCD). Findings published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, indicate that the preservation of DCD grafts using SNEVLP versus cold storage reduces bile duct and endothelial cell injury post transplantation.

September 10, 2014

Living Liver Donors Ambivalent with Donation

Living donors are important to increasing the number of viable grafts for liver transplantation. A new study published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, found that ambivalence is common among donor candidates. However, providing social support may help minimize the donors’ concerns regarding donation.

August 14, 2014

Broader Organ Sharing Won’t Harm Liver Transplant Recipients

New research shows that broader sharing of deceased donor livers will not significantly increase cold ischemia time (CIT)—the time the liver is in a cooled state outside the donor suggesting that this is not a barrier to broader sharing of organs.   However, findings published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, do indicate that broader sharing of organs will significantly increase the percentage of donor organs that are transported by flying rather than driving.

July 15, 2014

To Accept or Not Accept…Patients Want a Say in Liver Transplant Decisions

A novel study reveals that more than half of liver transplant patients want to be informed of donor risk at the time a liver is offered for transplantation. Nearly 80% of those patients want to be involved in the decision of whether or not to accept the organ according to findings published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

June 12, 2014

Survivors of Childhood Liver Transplant at Risk of Becoming “Skinny Fat”

New research reports that survivors of childhood liver transplant remain nutritionally compromised over the long-term. Findings published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, indicate that the recipients’ return to normal weight post-transplant was due to an increase in fat mass as body cell mass remained low, indicating a slim body composition with little lean muscle mass or “skinny fat”.

May 08, 2014

Urine Test Best Detects Alcohol Use in Liver Transplant Candidates, Recipients

Researchers from Italy confirm that urinary ethyl glucuronide (uEtG) accurately detects alcohol consumption in liver transplant candidates and recipients. The study published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, suggests that a combination of uEtG and the Alcohol Use Disorders Identification Test for alcohol consumption (AUDIT-c) are best in alerting doctors to alcohol consumption by patients undergoing evaluation for liver transplantation or who have received liver transplants.

April 01, 2014

Low Sodium Levels Pre-Transplant Does Not Affect Liver Transplant Recipient Survival

Researchers report that low levels of sodium, known as hyponatremia, prior to transplantation does not increase the risk of death following liver transplant.  Full findings are published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

March 13, 2014

Standardized Evaluation Consent Forms for Living Liver Donors Needed

New research reveals that 57% of liver transplant centers use living donor evaluation consent forms that include all the elements required by the Centers for Medicare and Medicaid Services (CMS) and 78% of centers addressed two-third or more of the items recommended by the Organ Procurement and Transplant Network (OPTN). The study published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, reviewed the living donor evaluation consent forms from 26 of the 37 transplant centers that evaluate living liver donors in the U.S.

February 13, 2014

Muscle Loss Ups Mortality and Sepsis Risk in Liver Transplant Candidates

Japanese researchers have determined that sarcopenia—a loss of skeletal muscle mass—increases risk of sepsis and mortality risk in patients undergoing live donor liver transplantation. Findings published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, suggest that post-transplant sepsis was reduced in candidates with sarcopenia who received early nutritional support with a feeding tube, known as enteral nutrition.

January 23, 2014

Morbidity Higher in Obese Liver Transplant Recipients with Diabetes, Survival Not Impacted

Researchers from New Zealand report that morbidity following liver transplant is highest among obese patients with diabetes, but these risk factors do not influence post-transplant survival. According to the study published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, body mass index (BMI) is effective for assessing obesity in liver transplant patients.

December 02, 2013

Liver Transplant Survival Rates Lower in Black than White Pediatric Patients

Novel research reveals racial and socioeconomic disparities among pediatric liver transplant patients. Findings published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, indicate that graft and patient survival was higher in white children than minorities.

November 11, 2013

Could Deceased Heart Attack Victims Expand Donor Pool?

Researchers from the U.K. suggest that using organs from donors after circulatory death (DCD) who also suffered a previous cardiac arrest out of the hospital environment could expand the pool of available livers for transplant.

October 02, 2013

Alcoholism Treatment Before, After Liver Transplantation Reduces Relapse

New research reports that liver transplant recipients who receive substance abuse treatment before and after transplantation have much lower alcohol relapse rates than those untreated or only treated prior to transplantation. A second study determines that continued alcohol abuse following liver transplantation decreases graft survival, further highlighting the importance of preventing alcohol relapse. Both studies are published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

August 06, 2013

Exercise May Reduce Heart Disease Risk in Liver Transplant Recipients

New research reveals that metabolic syndrome—risk factors that can lead to heart disease and/or stroke—is common in liver transplant recipients, with rates highest at one year following the procedure. Findings published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, indicate that exercise could reduce complications from metabolic disease in patients post-transplantation.

July 09, 2013

Poorer Health for Acetaminophen Overdose Survivors than Other Liver Failure Patients

Spontaneous survivors of acetaminophen overdose have significantly lower overall health compared to survivors or transplant recipients following acute liver failure caused by non-drug induced liver injury according to a new study published online in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

June 10, 2013

Partial Livers from Deceased Donors Saving the Lives of Infants

New research reveals that transplantation of partial livers from deceased adult and teen donors has become less risky for infants and young children, helping to save these young lives. Findings published online in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, indicate that risk of organ failure and mortality from partial or split liver transplant was comparable to whole organ transplant in this pediatric population.

April 25, 2013

Are Living Liver Donors at Risk from Life-threatening “Near-miss” Events?

A study published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, reports that donor mortality is about 1 in 500 donors with living donor liver transplantation (LDLT). Research of transplant centers around the world found that those with more experience conducting live donor procedures had lower rates of aborted surgery and life-threatening “near-miss” events.

April 04, 2013

Incarceration, Marijuana Use and Suicide Attempts May Hinder Liver Transplant Eligibility

Results from an anonymous survey of U.S. transplant providers report that incarceration, marijuana use, and psychiatric diagnoses, particularly suicide attempts, may lower patients’ eligibility for liver transplantation. The study published in the April issue of Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, also found that most providers would not offer transplants to patients with advanced age, those severely obese, or with lifetime imprisonment.

February 21, 2013

Antioxidant Improves Donated Liver Survival Rate to More Than 90%

Researchers from Italy have found that the antioxidant, N-acetylcysteine (NAC), when injected prior to harvesting of the liver, significantly improves graft survival following transplantation. Results published in the February issue of Liver Transplantation, a journal of the American Association for the Study of Liver Diseases (AASLD), suggest that the NAC effect on early graft function and survival is higher when suboptimal organs are used.

January 10, 2013

Decline in Available Liver Transplants Expected

A new study, funded in part by the National Institutes of Health (NIH) and Health Resources and Services Administration, and published in the January 2013 issue of Liver Transplantation, a journal of the American Association for the Study of Liver Diseases (AASLD), found that the non-use of donor livers climbed through 2010 due to a worsening of donor liver quality, primarily from donation following cardiac death. Diabetes, donor age, and body mass index (BMI) were also linked to a decrease in use of organs.

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