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The Royal Swedish Academy of Sciences has awarded the 2012 Nobel Prize in Chemistry jointly to Professors Robert J. Lefkowitz and Brian K. Kobilka for studies of G-protein–coupled receptors; both are published Wiley authors.
Targeted Attack on Tumors: Selective tumor treatment: β-galactosidase releases active agent from prodrugs
One of the largest challenges of chemotherapy lies in the fact that cancer cells must be killed while healthy tissue must be protected. French researchers have now introduced a new approach in the journal Angewandte Chemie: The enzyme β-galactosidase releases the active drug from an inactive precursor, known as a prodrug, which can only be taken up by tumor cells.
Carbon dioxide could be a useful alternative source of carbon for the chemical industry. It is inexpensive, is supplied in abundance by nature, and would help to reduce the consumption of fossil fuels. In addition, it would significantly improve the carbon footprint of fuels and chemical products. The largest barrier to this process is the high stability of the carbon dioxide molecule. In the journal Angewandte Chemie, Spanish researchers have now introduced a new process that traps carbon dioxide in the form of silyl formates, which are silicon-containing formic acid esters.
Introducing an easy-to-read, jargon-free overview of the patent application process for scientists and engineers
Electronic noses are used to sniff out exhaust fumes and assist with quality control of foods. Less well known is the fact that equivalent devices, electronic tongues, are capable of recognizing dissolved substances. In the journal Angewandte Chemie, French researchers have now presented a new and particularly simple approach to making an electronic tongue that can differentiate between proteins.
Math for the (chemistry) masses
Wiley is pleased to announce publication of the state-of-the-art, 6-volume Encyclopedia of Drug Metabolism and Interactions.
The expanded 6th Edition of the cornerstone reference work on occupational health and toxicology is now published by Wiley.
The most common form of strokes are caused by a sudden reduction in blood flow to the brain (ischemia) that leads to an inadequate supply of oxygen and nutrients. These so-called ischemic strokes are one of the leading causes of death and disability in industrialized nations. If they are not immediately remedied by medical intervention, areas of the brain may die off. In the journal Angewandte Chemie, Korean researchers have now proposed a new approach for supplemental treatment: Ceria nanoparticles could trap the reactive oxygen compounds that result from ischemia and cause cells to die.
Luminescent Ink from Eggs. Fluorescent carbon dots can be made by plasma pyrolysis and used as printer ink
Luminescent carbon nanoparticles based on carbon exhibit advantageous optical properties. They are also biocompatible, and therefore better suited for imaging procedures in the biosciences than metal-based semiconductor quantum dots. A variety of processes have thus been developed to make these miniature objects known as carbon dots or C-dots. Chinese researchers have now introduced a new method in the journal Angewandte Chemie, by which C-dots can be produced particularly quickly and inexpensively. In addition, they have demonstrated the use of these luminescent dots as printer ink.
In living systems, complex nano- and microscale structures perform a host of physical and biological functions. While two-dimensional patterns can be recreated fairly well with techniques like microlithography, three-dimensional structures represent a big challenge. In the journal Angewandte Chemie, American researchers have now reported a new method for the lithography-free etching of complex surface motifs with the use of biodegradable polymers and enzymes. Starting with structured microchannels, they have built an assembly for the isolation and concentration of cells from whole blood.
Glowing Flowers for Ultra-Trace Analysis of TNT: Selective optical TNT detection down to the sub-zeptomole level
Highly sensitive and highly selective tests are important for the early detection of disease, the detection of environmental toxins, or for the detection of explosives at airports. Increased selectivity for the target analytes helps to avoid false-positive results. In the journal Angewandte Chemie, Indian scientists have now introduced a specific detection method for the explosive TNT that can be used to detect even a single molecule.
Professor Christopher Bielawski to Receive Inaugural Journal of Polymer Science Innovation Award from Wiley
John Wiley & Sons, Inc., today announced that the inaugural Journal of Polymer Science Innovation Award will be issued today to Professor Christopher Bielawski at the Fall American Chemical Society (ACS) meeting in Philadelphia, PA.
Writing in the journal Drug Testing and Analysis, American researcher’s state the argument that marijuana is a harmless drug is no longer valid due to the emergence of ‘high potency’ marijuana and synthetic marijuana which pose a potential real threat for pregnant women.
Gold Nanoparticles Follow “Genetic Code”: Different sequences of DNA influence morphology of growing gold nanocrystals
Gold is not just the material of choice for pretty jewelry; it is also used in technology, for example in nanoscopic particles for applications such as catalysis, biomedicine, and sensors. In the journal Angewandte Chemie, a team of American and Chinese researchers has now demonstrated that the morphology of gold nanoparticles can be controlled when they are synthesized in the presence of DNA. Depending on the DNA sequence used, the shape and surface roughness can be varied.
Dual Role for CO2: Continuous hydrogenation of carbon dioxide to pure formic acid in supercritical CO2
To reduce fossil fuel consumption while simultaneously improving the carbon footprint of fuels and chemical products, the use of carbon dioxide as a carbon source could be an attractive option. In the journal Angewandte Chemie, German researchers have now introduced a method by which carbon dioxide can be catalytically hydrogenated to make formic acid. In this process, carbon dioxide is not only a starting material; it also acts—in a supercritical state—as the solvent for separation of the product. This integrated approach makes it possible to directly obtain free formic acid as the product in a single step for the first time.
John Wiley & Sons, Inc., today announced the launch of a new interdisciplinary review publication, WIREs Energy and Environment, publishing online this month.
Glowing Fingerprints: Researchers make latent fingerprints visible with help from electrochemiluminescence
Fingerprints are not just important in forensics and the identification of people; they can also be used for security clearance, access control, and the authentication of documents. In the journal Angewandte Chemie, Chinese researchers have now introduced a new fast method to make fingerprints visible at high resolution.
CO2 as a Carbon Source? Homogeneous catalysis: ruthenium phosphine complex hydrogenates carbon dioxide to make methanol
Fossil-based resources are declining and their use releases the greenhouse gas CO2. Both of these problems could be significantly mitigated if we could use CO2 as a carbon source for the production of fuels and chemical feedstocks. Various different approaches are currently being explored for the catalytic conversion of CO2 to methanol (CH3OH). In the journal Angewandte Chemie, German researchers have now introduced a new possibility to conduct this stepwise reaction of CO2 in solution with help of a homogeneous catalyst.
Gram staining of bacteria is a routine diagnostic method of long standing that can be used for initial diagnoses and to simplify the choice of antibiotics. It is a simple way to classify bacteria into two classes—Gram-positive and Gram-negative—under a microscope. In the journal Angewandte Chemie, American researchers have now introduced an improvement to this method: magnetic Gram staining. This allows for the class-specific, automated, magnetic detection and separation of bacteria.