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12:00 AM EST November 07, 2016

Do Second Opinions Matter in Prostate Cancer Care?

A new analysis indicates that many men with prostate cancer obtain second opinions from urologists before starting treatment, but surprisingly, second opinions are not associated with changes in treatment choice or improvements in perceived quality of prostate cancer care. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings also explore motivations for seeking second opinions, and suggest that second opinions may not reduce overtreatment in prostate cancer.

November 07, 2016

Physical and Cognitive Fitness May Affect ALS Risk

New research suggests that physical fitness, body mass index (BMI), IQ, and stress resilience in young adulthood may have effects on the risk of developing amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease.

November 07, 2016

Poor Children with Epilepsy May Face Social Hurdles

In a population-based Canadian study of children with epilepsy, each of whom had access to universal health care, those from poor families had the same medical course and remission rate as their wealthier counterparts, but they had a less favorable social outcome as adults.

November 07, 2016

Reproductive History and Hormone Use May Affect Women’s Cognitive Function

In a study of healthy postmenopausal women, reproductive life events related to sex hormones, including earlier age at menarche, later age at last pregnancy, length of reproductive period, and use of oral contraceptives were positively related to aspects of cognition in later life. 

November 07, 2016

Salamander Research May Lead to New Strategies to Treat Infertility

Some animals, such as the axolotl salamander, have the ability to generate large numbers of eggs—or oocytes—throughout life. Investigators who recently conducted detailed analyses of the axolotl provide insights on the mechanisms of ovarian regeneration that could assist regenerative medicine in treating pre-mature ovarian failure and reduced fertility in humans.

November 04, 2016

Many Colorectal Cancers Would be Missed with New Criteria for Patient Referral

Recently, in the UK, the National Institute for Health and Care Excellence (NICE) outlined criteria that should trigger primary care clinicians to refer patients with suspected colorectal cancer to see an oncologist. A new analysis of 1981 patients with lower gastrointestinal symptoms indicates that using these criteria, physicians would miss nearly 20% of colorectal cancers. 

November 03, 2016

Body Builders Aren’t Necessarily the Strongest Athletes

An increase in muscle size with exercise may not be directly related to an increase in muscle strength, according to a recent analysis of the literature.

November 01, 2016

Experts Explore How to Use and Share Routinely Collected Clinical Data on a Global Scale

Researchers are exploring ways to help clinicians and investigators use and share routinely collected medical data (such as information in electronic health records) to improve care and advance clinical research.

October 27, 2016

Many Young Children with Liver Failure Die while Waiting for a Transplant or Soon after Receiving One

A new analysis reveals unacceptable mortality rates in young US children with chronic liver disease while they are on transplant waiting lists as well as after transplantation.

October 27, 2016

Young People with Liver Conditions Face an Elevated Risk of Depression and Anxiety

Researchers have found that many teens and young adults with chronic liver conditions suffer from depression and anxiety, which can have considerable impacts on their emotional and physical health. The findings, which are published in Liver Transplantation, indicate that greater attention should be directed to the mental health of these young patients.

12:00 AM EDT October 24, 2016

Study Indicates that Advances in Precision Medicine Have Improved Breast Cancer Treatment

A new study examines how one early example of precision medicine—tumor genome testing—is being used in women with breast cancer to reduce overtreatment and maximize the benefits of chemotherapy. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the study found that physician recommendations and final treatment decisions correlated highly with test results, suggesting genome testing helped physicians identify which patients could most benefit from chemotherapy, and those for whom chemotherapy could be safely omitted. Additionally, these personalized recommendations appeared to eliminate racial/ethnic and educational disparities in testing or treatment; however, many women who were tested inaccurately recalled their test results.

October 20, 2016

Wiley Celebrates the 2016 Nobel Prize Laureates

John Wiley & Sons, Inc., (NYSE: JWa, JWb) would like to acknowledge the laureates honored with the 2016 Nobel Prize. Six of these laureates have had their work published in Wiley’s medical, physiology, chemistry and economics journals and books.

October 19, 2016

Research Reveals How Novel Osteoporosis Drug Increases Bone Mass

Abaloparatide, a selective activator of the parathyroid hormone receptor, has recently been shown to reduce fractures in postmenopausal women with osteoporosis. Now new research shows that abaloparatide increases bone mass in rats whose ovaries have been removed by stimulating bone formation, without effects on bone resorption.

October 14, 2016

Replacing Diet Beverages with Water May Help Diabetic Patients Lose Weight

In a study of 81 overweight and obese women with type 2 diabetes who usually consumed diet beverages and were on a weight loss program, those who substituted water for diet beverages after their lunch for 24 weeks had a greater decrease in weight (-6.40 vs. -5.25 kg) and body mass index (-2.49 vs. -2.06 kg/m2) compared with those who continued to consume diet beverages. 

October 13, 2016

Genetic Variants May Affect Breast Cancer Drug Concentrations and Patient Outcomes

In a study of 110 women taking the breast cancer drug anastrozole, there were significant differences in patients’ blood levels of the drug that corresponded with variations in the ABCB1 gene. Furthermore, variants in the CYP19A1 gene were associated with additional joint pain and cancer recurrence in patients.

October 13, 2016

Healthcare Workers Describe their Experiences in Caring for Patients with Ebola Virus Disease

Interviews conducted in 2015 with eight nurses and one physician who had worked in Ebola care in Sierra Leone revealed two themes: ‘Experiencing security by learning to manage risks’; and ‘Developing courage and growth by facing personal fears’. 

October 13, 2016

Starving Pancreatic Cancer Cells: Scientists Identify Potential Pancreatic Cancer Target

Researchers have found that a protein called SLC6A14 is overexpressed by several fold in pancreatic tumors taken from patients and in cancerous pancreatic cells lines compared with normal pancreatic tissue or normal pancreatic cells. SLC6A14 transports amino acids into cells to help with cellular metabolism.

October 13, 2016

Study Results May Help Patients after ACL Surgery

A new study provides critical information on how osteoarthritis may arise after anterior cruciate ligament (ACL) injury.

October 13, 2016

Understanding Why Potentially Inappropriate Medications Are Continued at the End of Life

A recent interview study has uncovered factors that may contribute to the use of potentially inappropriate medications (PIMs) at the end of life. 

October 11, 2016

Research Findings May Lead to Promising Zika Virus Drug Targets

Following recent outbreaks of Zika virus and the potential health dangers of infection, especially during pregnancy, scientists are striving to rapidly develop effective antiviral drugs that can halt transmission. Investigators who recently performed detailed analyses of the targets of a key enzyme of the Zika virus have uncovered peculiarities of the viral enzyme, called the NS3 protease.

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