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Majority of stillbirth cases remain unexplained, suggesting post mortem investigation needs to be refined, GOSH research finds
Analysis by a Great Ormond Street Hospital (GOSH) led team looking at the effectiveness of different elements of the post mortem process shows that, despite full standard investigation, in the majority of cases of stillbirth the cause remains unknown. The papers highlight the need for further research to improve post mortem techniques to better detect a cause of death.
The findings, published in the Journal of the American Geriatrics Society, come from the first systematic review of studies focused on oral health and cognition.
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A new analysis indicates that many men with prostate cancer obtain second opinions from urologists before starting treatment, but surprisingly, second opinions are not associated with changes in treatment choice or improvements in perceived quality of prostate cancer care. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings also explore motivations for seeking second opinions, and suggest that second opinions may not reduce overtreatment in prostate cancer.
New research suggests that physical fitness, body mass index (BMI), IQ, and stress resilience in young adulthood may have effects on the risk of developing amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease.
In a population-based Canadian study of children with epilepsy, each of whom had access to universal health care, those from poor families had the same medical course and remission rate as their wealthier counterparts, but they had a less favorable social outcome as adults.
In a study of healthy postmenopausal women, reproductive life events related to sex hormones, including earlier age at menarche, later age at last pregnancy, length of reproductive period, and use of oral contraceptives were positively related to aspects of cognition in later life.
Some animals, such as the axolotl salamander, have the ability to generate large numbers of eggs—or oocytes—throughout life. Investigators who recently conducted detailed analyses of the axolotl provide insights on the mechanisms of ovarian regeneration that could assist regenerative medicine in treating pre-mature ovarian failure and reduced fertility in humans.
Recently, in the UK, the National Institute for Health and Care Excellence (NICE) outlined criteria that should trigger primary care clinicians to refer patients with suspected colorectal cancer to see an oncologist. A new analysis of 1981 patients with lower gastrointestinal symptoms indicates that using these criteria, physicians would miss nearly 20% of colorectal cancers.
An increase in muscle size with exercise may not be directly related to an increase in muscle strength, according to a recent analysis of the literature.
Researchers are exploring ways to help clinicians and investigators use and share routinely collected medical data (such as information in electronic health records) to improve care and advance clinical research.
Many Young Children with Liver Failure Die while Waiting for a Transplant or Soon after Receiving One
A new analysis reveals unacceptable mortality rates in young US children with chronic liver disease while they are on transplant waiting lists as well as after transplantation.
Researchers have found that many teens and young adults with chronic liver conditions suffer from depression and anxiety, which can have considerable impacts on their emotional and physical health. The findings, which are published in Liver Transplantation, indicate that greater attention should be directed to the mental health of these young patients.
A new study examines how one early example of precision medicine—tumor genome testing—is being used in women with breast cancer to reduce overtreatment and maximize the benefits of chemotherapy. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the study found that physician recommendations and final treatment decisions correlated highly with test results, suggesting genome testing helped physicians identify which patients could most benefit from chemotherapy, and those for whom chemotherapy could be safely omitted. Additionally, these personalized recommendations appeared to eliminate racial/ethnic and educational disparities in testing or treatment; however, many women who were tested inaccurately recalled their test results.
John Wiley & Sons, Inc., (NYSE: JWa, JWb) would like to acknowledge the laureates honored with the 2016 Nobel Prize. Six of these laureates have had their work published in Wiley’s medical, physiology, chemistry and economics journals and books.
Abaloparatide, a selective activator of the parathyroid hormone receptor, has recently been shown to reduce fractures in postmenopausal women with osteoporosis. Now new research shows that abaloparatide increases bone mass in rats whose ovaries have been removed by stimulating bone formation, without effects on bone resorption.
In a study of 81 overweight and obese women with type 2 diabetes who usually consumed diet beverages and were on a weight loss program, those who substituted water for diet beverages after their lunch for 24 weeks had a greater decrease in weight (-6.40 vs. -5.25 kg) and body mass index (-2.49 vs. -2.06 kg/m2) compared with those who continued to consume diet beverages.
In a study of 110 women taking the breast cancer drug anastrozole, there were significant differences in patients’ blood levels of the drug that corresponded with variations in the ABCB1 gene. Furthermore, variants in the CYP19A1 gene were associated with additional joint pain and cancer recurrence in patients.
Interviews conducted in 2015 with eight nurses and one physician who had worked in Ebola care in Sierra Leone revealed two themes: ‘Experiencing security by learning to manage risks’; and ‘Developing courage and growth by facing personal fears’.
Researchers have found that a protein called SLC6A14 is overexpressed by several fold in pancreatic tumors taken from patients and in cancerous pancreatic cells lines compared with normal pancreatic tissue or normal pancreatic cells. SLC6A14 transports amino acids into cells to help with cellular metabolism.
A new study provides critical information on how osteoarthritis may arise after anterior cruciate ligament (ACL) injury.
A recent interview study has uncovered factors that may contribute to the use of potentially inappropriate medications (PIMs) at the end of life.
Following recent outbreaks of Zika virus and the potential health dangers of infection, especially during pregnancy, scientists are striving to rapidly develop effective antiviral drugs that can halt transmission. Investigators who recently performed detailed analyses of the targets of a key enzyme of the Zika virus have uncovered peculiarities of the viral enzyme, called the NS3 protease.