All new and updated articles currently being commissioned for Comprehensive Physiology are defined as Overview articles. Modeled on the existing Handbook of Physiology (HoP) chapters, these are highly detailed reviews aimed at researchers and advanced students in the field, as well as those in adjacent disciplines. We expect and encourage authors to draw on previously published HoP material in preparing these articles. The overviews should be comprehensive and self-contained; where they refer back to other sources for detailed information, those sources should be readily available to readers online. A link to the author template for Overview articles is provided below.