Synthesis, internalization, recycling, and regulation of peptide hormone receptors
Receptor-mediated endocytosis of polypeptide hormones by vascular endothelium
Receptor identification and characterization
Mediation of secretory cell function by G protein-coupled receptors
G protein-coupled receptors and the G protein family
Regulation of G protein-coupled receptors
Mammalian G-stimulated adenylyl cyclases
Calcium signaling systems
Protein kinases and phosphatases in cellular signaling
Phospholipid-derived second messengers
Membrane receptor-linked disease states
Cyclic adenosine monophosphate regulation of gene transcription
Targeted delivery of hormones to tissues by plasma proteins
Steroid hormone receptor families
Roles of cytochromes P-450 in the regulation of steroidogenesis
Cellular localization of receptors mediating the actions of steroid hormones
Autocrine/paracrine intermediates in hormonal action and modulation of cellular responses to hormones
Role of pulsatility in hormonal action
Apoptosis
The Endocrine Pancreas and Regulation of Metabolism
Historical Perspectives
General introduction: reminiscences and reflections on fifty years of the endocrine pancreas
Insulin Production, Processing, and Degradation
Glucagon and glucagon-like peptide production and degradation
Production, action, and degradation of somatostatin
Amylin and related proteins: physiology and pathophysiology
Actions of Islet Cell Hormones at the Molecular Level
Insulin receptor tyrosine kinase
Molecular aspects of insulin signaling
Glucagon signal-transduction mechanisms
Regulation of glucose transporters by insulin and exercise: cellular effects and implications for diabetes
Regulation of fatty acid biosynthesis and lipolysis
Regulation of protein metabolism in muscle
Regulation of protein metabolism in liver
Regulation of glucose metabolism in skeletal muscle
Regulation of glycogen metabolism
Regulation of gluconeogenesis in liver
Regulation of ketogenesis in liver
Pancreas and lipoprotein metabolism
Genetic regulation of glucose metabolism
Action of Islet Cell Hormones In Vivo
Insulin and protein metabolism
Control of glucose production in vivo by insulin and glucagon
Regulation of hepatic glucose uptake
Regulation of muscle glucose uptake in vivo
Influences of Hormones Acting as Acute Metabolic Regulators on the Actions of Islet Hormones
Metabolic actions of growth hormone
Thyroid hormone regulation of islet cell hormone metabolic actions
Insulin-like growth factor-1 and the endocrine pancreas
Integrated Hormonal Responses to Physiological Challenges
Effects of pregnancy on metabolism
Aging pancreas: effects of aging on insulin secretion and action
Sepsis-induced changes in pancreatic hormone secretion
Obesity
Prevention and correction of hypoglycemia
Type I diabetes mellitus (insulin-dependent diabetes mellitus)
Pathogenesis of type 2 diabetes
Insulin resistance, compensatory hyperinsulinemia, and coronary heart disease: syndrome X revisited
Starvation
Regulatory Molecules of Sodium and Potassium Balance
Renin
Angiotensinogen
Molecular and physiological aspects of angiotensin I converting enzyme
Angiotensins
Aldosterone
Endocrine hypertension
Endocrine control of sodium balance
Endocrine control of potassium balance
Hormones Regulating Electrolyte and Water Balance
Tissue kallikrein-kinin system
Natriuretic peptides
Physiological responses to natiuretic hormones
Antidiuretic hormone: synthesis and release
Renal actions of vasopressin
Endocrine control of water balance
Endocrine control of acid-base balance
Endocrine Regulation of Calcium and Phosphate Balance
Parathyroid hormone and polyhormones: production and export
Roles of parathyroid hormone and parathyroid hormone-related peptide in calcium metabolism and bone biology: their biological actions and receptors
Vitamin D
Coping with the Environment: Neural and Endocrine Mechanisms
Primary Mediators of the Coping Response
Synthesis, storage, and secretion of adrenal medullary hormones: physiology and pathophysiology
Sympathetic nervous system physiology and pathophysiology in coping with the environment
Catecholamines in the brain and responses to environmental challenges
Actions of corticotropin on the adrenal cortex: biochemistry and cell biology
Proopiomelanocortin synthesis and cell-specific processing
Regulation and actions of corticotropin-releasing hormone
Corticotropin-releasing factor in brain: executive gating of neuroendocrine and functional outflow
Fear, Stress, and Coping
Coping with danger: the neural basis of defensive behavior and fearful feelings
Neurobiology of interpreting and responding to stressful events: paradigmatic role of the hippocampus
Chronic stress and energy balance: role of the hypothalamo-pituitary-adrenal axis
Adrenocortical responses to stress and their modulation in free-living vertebrates
Stress and Coping During the Life Course
Development of the hypothalamic-pituitary-adrenal axis and the stress response
Development of individual differences in behavioral and endocrine responses to stress: role of the postnatal environment
Mechanisms of glucocorticoid actions in stress and brain aging
Coping: Impact of Diurnal Rhythms and Sleep
Roles of sleep-wake and dark-light cycles in the control of endocrine, metabolic, cardiovascular, and cognitive function
Hormones, cytokines, and sleep
Stress, Coping, and Immune Defenses
Regional neural regulation of immunity: anatomy and function
Role of endogenous glucocorticoids in immune system function: regulation and counterregulation
Interactions between the hypothalamic-pituitary-adrenal axis and immune system during viral infection: pathways for environmental effects on disease expression
Regulation of inflammatory autoimmune diseases
Immunophysiology: the interaction of hormones, lymphohemopoietic cytokines, and the neuroimmune axis
Environmental factors and disease: stress and cancer
Stress, Coping, and the Social Environment
Physiological and pathophysiological implications of social stress in mammals
Social Ordering and Health
Hormonal Control of Growth
Growth and its Regulation
Growth process
Somatic growth and its regulation
Hormonal regulation of growth and development of nonmammalian vertebrates
Hormones and growth in domestic animals
Hormonal regulation of growth and metabolic effects of growth hormone
Structure-function relationships of growth hormone and other members of the growth hormone gene family
Regulation of growth hormone gene expression
Growth hormone-releasing hormone: discovery, regulation, and actions
Somatostatin
Growth hormone releasing peptides
Feedback regulation of growth hormone secretion
Growth hormone secretory pattern and statural growth
Growth hormone receptor
Molecular events in growth hormone-receptor interaction and signaling
Somatomedin hypothesis of growth hormone action
Dual effector theory
Regulation of amino acid and protein metabolism by growth hormone
Insulin-like growth factors: gene structure and regulation
Insulin-like growth factor binding proteins
Molecular mechanisms of insulin-like growth factor I receptor function: implications for normal physiology and pathological states
Insulin-like growth factor-I actions on somatic growth
Regulation of growth by insulin-like growth factor II
Thyroid hormone receptors
Regulation of gene expression by thyroid hormones: relation to growth and development
Insulin as a growth-promoting hormone
Stomach
Neural and hormonal control of gastric secretion
Inhibition of gastric acid secretion
Electrophysiology of gastric ion transport
Cell biology of hydrochloric acid secretion
Biochemistry of gastric acid secretion: H+ K+-ATPase
Intracellular activation events for parietal cell hydrochloric acid secretion
Cellular basis of pepsinogen secretion
Gastric mucosal barrier
Secretion of bicarbonate by gastric and duodenal mucosa
Immunological probes of gastrointestinal secretion
Functional development of stomach
Gastrointestinal mucus
Adipose Tissue
General Perspectives
Preface
Introduction-a perspective
Structural Aspects of Adipose Tissue
Energy storage
Relative importance of different tissues in the synthesis of fatty acids
Comparative anatomy of adipose tissue
Adipose tissue in migratory birds
Metabolic pathways in the insect fat body
Fat metabolism in fish
Physiological role of brown adipose tissue
Development of adipose tissue
Histogenesis
Fine structure of adipose tissues
Morphology of adipose tissue: a microscopic anatomy of fat
Pathological anatomy of adipose tissue
Lipid components of adipose tissue
Fatty substances containing ether linkages
Fatty acid patterns in human adipose tissue
Structural sugars in adipose tissue
Metabolism
Fatty acid synthesis in adipose tissue
Triglyceride metabolism
Enzymes involved in carbohydrate metabolism in adipose tissue
Glyceride biosynthesis, glyceride breakdown and glycogen breakdown in adipose tissue: mechanisms and regulation
Pathways of glucose metabolism
Pathways of glucose metabolism II
Fructose metabolism in adipose tissue from normal and diabetic rats
Clearing factor lipase activity of adipose tissue
Adipose tissue lipases II
Hormone-sensitive lipolytic activity of adipose tissue
Glycogen metabolism in adipose tissue
Adipose tissue in diabetes
Regulation of fatty acid release with particular reference to pituitary factors
Release of free fatty acids from adipose tissue in vitro in relation to rates of triglyceride synthesis and degradation
Lipid peroxidation
Net gas exchange and oxygen consumption
Conversion of amino acids to fatty acids
Amino acid and protein metabolism
Regulation of fatty acid esterification in adipose tissue incubated in vitro
Effect of feeding on fatty acid synthesis
Effects of aging on the composition and metabolism of adipose tissue in the rat
Effect of biologically active peptides on adipose tissue
Comparative physiology of adipose tissue in different sites and in different species
Selective labeling of adipose tissue in vivo
Perfusion of isolated adipose tissue: FFA release and blood flow in rat parametrial fat body
Metabolism of human adipose tissue in vitro
Metabolism of isolated fat cells
Metabolism of isolated adipose tissue: a summary
Chylomicron metabolism: uptake and metabolism by perfused adipose tissue
Metabolism of lipids in chylomicrons and very low density lipoproteins
Particulate lipid components in plasma
Regulation of Adipose Tissue
Effect of dietary and endocrine factors on adipose tissue growth
Pituitary gland and the mobilization of fat
Adipokinetic property of hypophyseal peptides and catecholamines: a problem in comparative endocrinology
In vivo and in vitro adipokinetic effects of corticotropin and related peptides
Lipid-mobilizing activity during fasting
Inhibition of lipid mobilization
Autonomic nervous system and adipose tissue
Autonomic nervous system and adipose tissue
Action of lipomobilizing hormones on adipose tissue
Psychogenic effects on lipid mobilization
Adiposity
Some physiological and clinical implications of lipid mobilization from adipose tissue
Metabolism of adipose tissue in experimental obesity
Measurement of human adipose tissue mass
Lipid composition and metabolism of subcutaneous adipose tissue and lipoma of man
Lipodystrophy
Effect of adipose tissue extracts on the insulin activity of human serum
Regulation of adipose tissue metabolism within the intact organism: a summary
