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Gastrointestinal and Liver Physiology

Motility

  • Historical Perspectives

    • Gastrointestinal physiology, 1895-1975: motility
  • Musculature

    • Structure of intestinal musculature
    • Distribution and exchange of electrolytes in gastrointestinal muscle cells
    • Electrophysiology of dissociated gastrointestinal muscle cells
    • Electrophysiology of the gastric musculature
    • Electrophysiology of the intestinal musculature
    • Electrophysiology of colonic smooth muscle
    • Mechanical properties of gastrointestinal smooth muscle
  • Neurobiology

    • Enteric neurons in culture
    • Interstitial cells of Cajal
    • Identification of transmitters of functionally defined enteric neurons
    • Neurotransmitter release in the enteric nervous system
    • Neuromuscular transmission in the gastrointestinal tract
    • Electrical and synaptic behavior of enteric neurons
    • Physiology of prevertebral ganglia in mammals with special reference to inferior mesenteric ganglion
    • Sensory afferents from the gastrointestinal tract
    • Control centers in the central nervous system for regulating gastrointestinal motility
    • Central nervous system mechanisms in deglutition and emesis
  • Pharmacology

    • Pharmacology of drugs acting on gastrointestinal motility
    • Pharmacology of neuroendocrine peptides
  • Motor Function

    • In vivo myoelectric activity: methods, analysis, and interpretation
    • Esophageal motility
    • Determinants of gastric emptying and transit in the small intestine
    • Colonic motility
    • Villous motility
    • Sphincteric function
    • Motor function of anorectum and pelvic floor musculature
    • Motility of the biliary system
    • Pharmacology of biliary tract
  • Abnormal Motility

    • Parasite infections and gastrointestinal motility
    • Alterations of small intestine motility by bacteria and their enterotoxins
    • Motor and myoelectric activity associated with vomiting, regurgitation, and nausea
    • Adaptation to surgical perturbations
  • Comparative Physiology

    • Gastrointestinal motor functions in ruminants
    • Avian gastrointestinal motor function

Circulation

  • Structure

    • Histoanatomy and ultrastructure of vasculature of alimentary tract
  • Hemodynamics

    • Gastrointestinal blood flow-measuring techniques
    • Physiology of gastric circulation
    • Microcirculation of the intestinal mucosa
    • Gastrointestinal circulation and motor function
    • Hepatic circulation
    • Circulation of the pancreas and salivary glands
    • Neonatal intestinal circulation
  • Neurobiology

    • Electrophysiological and neuromuscular relationships in extramural blood vessels
    • Neuromuscular transmission in intramural blood vessels
    • Neurohormonal control of gastrointestinal blood flow
  • Abnormal Circulation

    • Pathophysiology of gastrointestinal circulation
  • Lymphatic Circulation

    • Gastrointestinal lymphatics

Neural and Endocrine Biology

  • Properties of Gut Peptides

    • Molecular biology of gut peptides
    • Sequences of natural gut peptides, related peptides, and their precursors
    • Posttranslational processing of gut peptides
    • Endocrine cells of the gut
    • Structure and neurochemical organization of the enteric nervous system
    • Distribution of gut peptides
    • Identification of physiological function of gut peptides
    • Comparative neuroendocrinology of gut peptides
    • Receptors for gut peptides and other secretagogues on pancreatic acinar cells
    • Gastric mucosal receptors
    • Peptide receptors in intestinal epithelium
    • Liver receptors for regulatory peptides
    • Receptors for gut peptides on smooth muscle cells of the gut
    • Trophic effects of gut peptides
  • Structure and Function of Gut Peptides

    • Gastrin
    • Cholecystokinin
    • Secretin
    • Gastric inhibitory polypeptide
    • Somatostatin
    • Gut glucagon
    • Pancreatic polypeptide family: pancreatic polypeptide, neuropeptide Y, and peptide YY
    • Motilin
    • Neurotensin
    • Bombesin-like peptides
    • Vasoactive intestinal peptide
    • Opioid peptides of the gut
    • Gut tachykinins
    • Newly discovered gut peptides

Salivary, Gastric, Pancreatic, and Hepatobiliary Secretion

  • Salivary

    • Fluid and electrolyte secretion by salivary glands
    • Electrophysiology of salivary and pancreatic acinar cells
    • Calcium signaling system in salivary glands
    • Cellular regulation of amylase secretion by the parotid gland
    • Salivary mucin secretion
    • Functional differentiation of salivary glands
    • Secretory membranes and the exocrine storage compartment
  • Stomach

    • Neural and hormonal control of gastric secretion
    • Inhibition of gastric acid secretion
    • Electrophysiology of gastric ion transport
    • Cell biology of hydrochloric acid secretion
    • Biochemistry of gastric acid secretion: H+ K+-ATPase
    • Intracellular activation events for parietal cell hydrochloric acid secretion
    • Cellular basis of pepsinogen secretion
    • Gastric mucosal barrier
    • Secretion of bicarbonate by gastric and duodenal mucosa
    • Immunological probes of gastrointestinal secretion
    • Functional development of stomach
    • Gastrointestinal mucus
  • Pancreas

    • Pancreatic secretion of electrolytes and water
    • Cellular regulation of pancreatic secretion
    • Signaling transduction in hormone- and neurotransmitter-induced enzyme secretion from the exocrine pancreas
    • Regulation of digestive reactions by the pancreas
    • Cellular compartmentation and protein processing in the exocrine pancreas
    • Selective regulation of gene expression in the exocrine pancreas
    • Long-term regulation of pancreatic function studied in vitro
    • Structural and secretory polarity in the pancreatic acinar cell
  • Hepatobiliary

    • Overview of bile secretion
    • Enterohepatic circulation of bile acids
    • Cellular mechanisms of hepatic fluid and electrolyte transport
    • Physical chemistry of bile
    • Pathways and function of biliary protein secretion
    • Hepatocyte lysosomes in intracellular digestion and biliary secretion
    • Hepatic transport of organic solutes
    • Transport and metabolism in the hepatobiliary system

Intestinal Absorption and Secretion

  • Basic Principles of Structure and Function

    • Principles of membrane transport
    • Biology of sodium-absorbing epithelial cells: dawning of a new era
    • Functional morphology of epithelium of the small intestine
    • Functional morphology of the large intestine
    • Mechanism of fluid transport by epithelia
    • Enterocyte cytoskeleton: its structure and function
    • Use of cultured cell lines in studies of intestinal cell differentiation and function
  • Intestinal Transport of Inorganic Ions

    • Ion transport across the large intestine
    • Comparative physiology of colonic electrolyte transport
    • Ion transport across mammalian small intestine
    • Salt and water transport by gallbladder epithelium
    • Inorganic phosphate absorption in small intestine
    • Transport of calcium
    • Iron absorption
  • Intestinal Transport of Organic Compounds

    • Transport of weak electrolytes
    • Intestinal transport of bile acids
    • Molecular biology of Na-/glucose symport
    • Dietary protein processing: intraluminal and enterocyte surface events
    • Intestinal transport of water-soluble vitamins
    • Gastric intrinsic factor and cobalamin absorption
    • Immunoglobulin A secretion
    • Luminal events in gastrointestinal lipid digestion
    • Enterocyte lipid absorption and secretion
  • Regulation of Intestinal Ion Transport

    • Neurohormonal control of fluid and electrolyte transport in intestinal mucosa
    • Immunophysiology of intestinal electrolyte transport