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Muscle Physiology

Skeletal Muscle

  • Structure

    • Surface and internal morphology of skeletal muscle
    • Structure and function of membrane systems of skeletal muscle cells
    • Quantitative ultrastructure of mammalian skeletal muscle
    • Immunological techniques in fluorescence and electron microscopy applied to skeletal muscle fibers.
    • Structure of vertebrate striated muscle as determined by X-ray-diffraction studies
  • Contraction

    • Force generation and shortening in skeletal muscle
    • Energetics of muscle contraction
    • Chemical mechanism of myosin-catalyzed ATP hydrolysis
    • Conformational changes and molecular dynamics of myosin
  • Excitation-Contraction Coupling

    • Electrical properties of striated muscle
    • Impedance measurement of the electrical structure of skeletal muscle
    • Inward spread of activation in twitch skeletal muscle fibers
    • Optical studies of excitation-contraction coupling using voltage-sensitive and calcium-sensitive probes
    • Pharmacological investigations of excitation-contraction coupling
    • Mechanism of Ca2+ transport by sarcoplasmic reticulum
  • Specialization, Adaptation, and Disease

    • Physiology of insect flight muscle
    • Emergence of specialization in skeletal muscle
    • Alterations in myofibril size and structure during growth, exercise, and changes in environmental temperature
    • Skeletal muscle adaptability: significance for metabolism and performance
    • Diseases of skeletal muscle