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Wiley Nobel Laureates 2013

Nobel Assembly at Karolinska Institutet has awarded the Nobel Prize in Physiology or Medicine for 2013 to James E. Rothman, Thomas C. Südhof and Randy W. Schekman for discovering how cells transport material.

James E. Rothman

Membrane assembly: Synthesis and intracellular processing of the vesicular stomatitis viral glycoprotein
Journal of Supramolecular Structure

Conformational change of chaperone Hsc70 upon binding to a decapeptide: A circular dichroism study
Protein Science

The protein machinery of vesicle budding and fusion
Protein Science

Putative fusogenic activity of NSF is restricted to a lipid mixture whose coalescence is also triggered by other factors
The EMBO Journal

 


Randy W. Schekman

Molecular machinery required for protein transport from the endoplasmic reticulum to the golgi complex
BioEssays

Regulated Oligomerization Induces Uptake of a Membrane Protein into COPII Vesicles Independent of Its Cytosolic Tail
Traffic

Cargo selection into COPII vesicles is driven by the Sec24p subunit
The EMBO Journal

GTP/GDP exchange by Sec12p enables COPII vesicle bud formation on synthetic liposomes
The EMBO Journal

Self-assembly of minimal COPII cages
EMBO reports


Thomas C. Südhof

Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release
The EMBO Journal

Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion
The EMBO Journal

Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion
The EMBO Journal

Redundant functions of RIM1? and RIM2? in Ca2+-triggered neurotransmitter release
The EMBO Journal

An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus
The EMBO Journal

How Tlg2p/syntaxin 16 'snares’ Vps45
The EMBO Journal

The Molecular Machinery of Neurotransmitter Release (Nobel Lecture)
Angewandte Chemie International Edition

An unusual C2-domain in the active-zone protein piccolo: implications for Ca2+ regulation of neurotransmitter release
The EMBO Journal

Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation
The EMBO Journal

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis
The EMBO Journal

α-latrotoxin triggers transmitter release via direct insertion into the presynaptic plasma membrane
The EMBO Journal

CSP α knockout causes neurodegeneration by impairing SNAP-25 function
The EMBO Journal

A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?
The EMBO Journal

Increased anxiety-like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2
Genes, Brain and Behavior

Calelectrin, a Calcium-Dependent Membrane-Binding Protein Associated with Secretory Granules in Torpedo Cholinergic Electromotor Nerve Endings and Rat Adrenal Medulla
Journal of Neurochemistry

Characterization of Calelectrin, a Ca2+-Binding Protein Isolated from the Electric Organ of Torpedo marmorata
Journal of Neurochemistry

High-level expression of the 32.5-kilodalton calelectrin in ductal epithelia as revealed by immunocytochemistry
Differentiation

Mammary gland Ca2+-binding (-dependent) proteins: Identification as calelectrins and calpactin I/p36
Molecular Reproduction & Development

Synaptic Vesicle Traffic: Rush Hour in the Nerve Terminal
Journal of Neurochemistry

Identification, expression, and crystallization of the protease-resistant conserved domain of synapsin I
Protein Science

The Making of Neurexins
Journal of Neurochemistry

Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses
European Journal of Neuroscience

Common EF-hand motifs in cholinesterases and neuroligins suggest a role for Ca2+ binding in cell surface associations
Protein Science

Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation
Journal of Neurochemistry

Differential expression of active zone proteins in neuromuscular junctions suggests functional diversification
European Journal of Neuroscience

Deletion of α-neurexins does not cause a major impairment of axonal pathfinding or synapse formation
Journal of Comparative Neurology

Cysteine string protein-α is essential for the high calcium sensitivity of exocytosis in a vertebrate synapse
European Journal of Neuroscience

Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+-induced glucagon exocytosis in pancreas
The Journal of Physiology

Increased anxiety-like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2
Genes, Brain and Behavior

Rab3 Proteins Involved in Vesicle Biogenesis and Priming in Embryonic Mouse Chromaffin Cells
Traffic

Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction
Journal of Neurochemistry

Cerebellins meet neurexins (Commentary on Matsuda & Yuzaki)
European Journal of Neuroscience

Region-specific deletions of RIM1 reproduce a subset of global RIM1 ? α-/- phenotypes
Genes, Brain and Behavior

 

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Online ISBN: 9780471203070
 

The 2013 Nobel Prize in Chemistry was jointly awarded to Martin Karplus, Michael Levitt, and Arieh Warshel for laying the foundations to how computer programs are used to understand and predict chemical processes.

Martin Karplus

Development of Multiscale Models for Complex Chemical Systems: From H+H2 to Biomolecules (Nobel Lecture)
Angewandte Chemie International Edition

Understanding the microsolvation of salts in molecular clusters
International Journal Of Quantum Chemistry

Significance of Molecular Dynamics Simulations for Life Sciences
Israel Journal Of Chemistry

Asymmetric Synthesis of Pochonin E and F, Revision of Their Proposed Structure, and Their Conversion to Potent Hsp90 Inhibitors
Chemistry - A European Journal

Dynamical aspects of molecular recognition
Journal Of Molecular Recognition

Signaling pathways of PDZ2 domain: A molecular dynamics interaction correlation analysis
Proteins: Structure, Function, And Bioinformatics

Allostery and cooperativity revisited
Protein Science

Electrostatic energies and forces computed without explicit interparticle interactions: A linear time complexity formulation
Journal Of Computational Chemistry

Study of the insulin dimerization: Binding free energy calculations and per-residue free energy decomposition
Proteins: Structure, Function, And Bioinformatics

X-ray structural and simulation analysis of a protein mutant: The value of a combined approach
Proteins: Structure, Function, And Bioinformatics

Investigation of glucose binding sites on insulin
Proteins: Structure, Function, And Bioinformatics

The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48
Acta Crystallographica Section D

Comparison of the transition state ensembles for folding of Im7 and Im9 determined using all-atom molecular dynamics simulations with φ value restraints
Proteins: Structure, Function, And Bioinformatics

The role of carbon-donor hydrogen bonds in stabilizing tryptophan conformations
Proteins: Structure, Function, And Bioinformatics

Molecular dynamics of biological macromolecules: A brief history and perspective
Biopolymers

Understanding the Role of Active-Site Residues in Chorismate Mutase Catalysis from Molecular-Dynamics Simulations
Angewandte Chemie International Edition

Modeling zinc in biomolecules with the self consistent charge-density functional tight binding (SCC-DFTB) method: Applications to structural and energetic analysis
Journal Of Computational Chemistry

An improved method for nonbonded list generation: Rapid determination of near-neighbor pairs
Journal Of Computational Chemistry

Why protein R-factors are so large: A self-consistent analysis
Proteins: Structure, Function, And Bioinformatics

Native and non-native interactions along protein folding and unfolding pathways
Proteins: Structure, Function, And Bioinformatics

Theoretical studies on the hydrolysis of phosphate diesters in the gas phase, solution, and RNase A
International Journal Of Quantum Chemistry

Structures of scrambled disulfide forms of the potato carboxypeptidase inhibitor predicted by molecular dynamics simulations with constraints
Proteins: Structure, Function, And Bioinformatics

Dynamic ligand design and combinatorial optimization: Designing inhibitors to endothiapepsin
Proteins: Structure, Function, And Bioinformatics

 


Arieh Warshel

Simulations of ion current in realistic models of ion channels: The KcsA potassium channel
Proteins: Structure, Function, And Bioinformatics

 


Michael Levitt

Protein decoy assembly using short fragments under geometric constraints
Biopolymers

 

The Royal Swedish Academy of Sciences has awarded the Nobel Prize in Physics for 2013 to Peter W. Higgs and François Englert for their theoretical discovery of the Higgs Boson; a discovery which was confirmed by CERN in 2012.

François Englert

The BEH mechanism and its scalar boson
Annalen Der Physik

 

The Norwegian Nobel Committee has awarded the Nobel Peace Prize for 2013 to the Organization for the Prohibition of Chemical Weapons (OPCW) for its extensive efforts to eliminate chemical weapons.

The following book chapters and journal papers have been published by authors affiliated to the OPCW.

Microsynthesis and mass spectral study of Chemical Weapons Convention related 2-alkyl-1,3,6,2-dioxathiaphosphocane-2-oxides
Rapid Communications in Mass Spectrometry

Worldwide Governmental Efforts to Locate and Destroy Chemical Weapons and Weapons Materials
Annals of the New York Academy of Sciences

 

The Sveriges Riksbank Prize in Economic Sciences in Memory of Alfred Nobel for 2013 has been awarded jointly to Eugene F. Fama, Lars Peter Hansen and Robert J. Shiller.

Eugene F. Fama

Risk, Return and Equilibrium: Some Clarifying Comments
The Journal of Finance

Components of Investment Performance
The Journal of Finance

A Note on the Market Model and the Two-Parameter Model
The Journal of Finance

Long-Term Growth in a Short-Term Market
The Journal of Finance

Stock Returns, Expected Returns, and Real Activity
The Journal of Finance

The Cross-Section of Expected Stock Returns
The Journal of Finance

Size and Book-to-Market Factors in Earnings and Returns
The Journal of Finance

Multifactor Explanations of Asset Pricing Anomalies
The Journal of Finance

The CAPM is Wanted, Dead or Alive
The Journal of Finance

Taxes, Financing Decisions, and Firm Value
The Journal of Finance

Value versus Growth: The International Evidence
The Journal of Finance

Characteristics, Covariances, and Average Returns: 1929 to 1997
The Journal of Finance

Disappearing Dividends: Changing Firm Characteristics or Lower Propensity to Pay?
Journal of Applied Corporate Finance

The Equity Premium
The Journal of Finance

The Value Premium and the CAPM
The Journal of Finance

Dissecting Anomalies
The Journal of Finance

Average Returns, B/M, and Share Issues
The Journal of Finance

Luck versus Skill in the Cross-Section of Mutual Fund Returns
The Journal of Finance

Was There Ever a Lending Channel?
European Financial Management


Lars Peter Hansen

A Quartet of Semigroups for Model Specification, Robustness, Prices of Risk and Model Detection
Journal of the European Economic Association

Robustness and U.S. Monetary Policy Experimentation
Journal of Money, Credit and Banking

Long-Term Risk: An Operator Approach
Econometrica

Fragile beliefs and the price of uncertainty
Quantitative Economics

Dynamic Valuation Decomposition Within Stochastic Economies
Econometrica

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Online ISBN: 9780470061602
 

Robert J. Shiller

Aligning Incentives at Systemically Important Financial Institutions: A Proposal by the Squam Lake Group
Journal of Applied Corporate Finance

The Use of Volatility Measures in Assessing Market Efficiency
The Journal of Finance

Stock Prices, Earnings, and Expected Dividends
The Journal of Finance

Comovements in Stock Prices and Comovements in Dividends
The Journal of Finance

Forecasting Prices and Excess Returns in the Housing Market
Real Estate Economics

Measuring Asset Values for Cash Settlement in Derivative Markets: Hedonic Repeated Measures Indices and Perpetual Futures
The Journal of Finance

Hedging Inflation and Income Risks
The Manchester School

Labor Income Indices Designed for Use in Contracts Promoting Income Risk Management
Review of Income and Wealth

Moral Hazard in Home Equity Conversion
Real Estate Economics

Comments on John Geanakoplos's “The Ideal Inflation-Indexed Bond and Irving Fisher's Impatience Theory of Interest with Overlapping Generations”
American Journal of Economics and Sociology

Samuelson's Dictum and The Stock Market
Economic Inquiry

Tools for Financial Innovation: Neoclassical versus Behavioral Finance
Financial Review

Property Derivatives for Managing European Real-Estate Risk
European Financial Management

A Pricing Framework for Real Estate Derivatives
European Financial Management