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Wiley Nobel Laureates 2011

The Nobel Prize in Physiology or Medicine for 2011 was jointly awarded to the late Professor Ralph M. Steinman for his discovery of the dendritic cell and its role in adaptive immunity and to Professor Bruce A. Beutler and Dr. Jules A. Hoffmann for their discoveries concerning the activation of innate immunity.

Ralph M. Steinman

Dendritic Cell Function in Vivo during the Steady State: A Role in Peripheral Tolerance
Annals of the New York Academy of Sciences

Active immunization against cancer with dendritic cells: The near future
International Journal of Cancer

Isolation of Dendritic Cells
Current Protocols in Immunology

CD8+ T cells from most HIV-1-infected patients, even when challenged with mature dendritic cells, lack functional recall memory to HIV gag but not other viruses
European Journal of Immunology

Presentation of SIVgag to monkey T cells using dendritic cells transfected with a recombinant adenovirus
European Journal of Immunology

Some Scientific and Organizational Challenges in Cancer Immunology
Annals of the New York Academy of Sciences

Harnessing the Immune System Against Human Glioma
Annals of the New York Academy of Sciences

Some active areas of DC research and their medical potential
European Journal of Immunology

Murine Langerin+ dermal dendritic cells prime CD8+ T cells while Langerhans cells induce cross-tolerance
EMBO Molecular Medicine

A new synthetic TLR4 agonist, GLA, allows dendritic cells targeted with antigen to elicit Th1 T-cell immunity in vivo
European Journal of Immunology

Targeting of LcrV virulence protein from Yersinia pestis to dendritic cells protects mice against pneumonic plague
European Journal of Immunology

Features of the dendritic cell lineage
Immunological Reviews

HIV gag protein is efficiently cross-presented when targeted with an antibody towards the DEC-205 receptor in Flt3 ligand-mobilized murine DC
European Journal of Immunology

The Human Cancer Antigen Mesothelin Is More Efficiently Presented to the Mouse Immune System when Targeted to the DEC-205/CD205 Receptor on Dendritic Cells
Annals of the New York Academy of Sciences

DEC-205/CD205+ dendritic cells are abundant in the white pulp of the human spleen, including the border region between the red and white pulp
Immunology

Broad T cell immunity to the LcrV virulence protein is induced by targeted delivery to DEC-205/CD205-positive mouse dendritic cells
European Journal of Immunology

Dendritic cells: Understanding immunogenicity
European Journal of Immunology

Dendritic cells expand antigen-specific Foxp3+CD25+CD4+ regulatory T cells including suppressors of alloreactivity
Immunological Reviews

Invariant natural killer T cells are preserved in patients with glioma and exhibit antitumor lytic activity following dendritic cell-mediated expansion
International Journal of Cancer

Some interfaces of dendritic cell biology
APMIS

The Hematopoietic Development of Dendritic Cells: A Distinct Pathway for Myeloid Differentiation
Stem Cells

Cover Image
Print ISBN: 9781573317597
Cover Image
Print ISBN: 9781573316071

Jules A. Hoffmann

Primitive immune systems
Immunological Reviews

Akirin2 is critical for inducing inflammatory genes by bridging IκB-ζ  and the SWI/SNF complex
The EMBO Journal

Determination of disulfide bridges in natural and recombinant insect defensin A
European Journal of Biochemistry

New insights into Drosophila larval haemocyte functions through genome-wide analysis
Cellular Microbiology

cDNAs from neurosecretory cells of brains of Locusta migratoria (Insecta, Orthoptera) encoding a novel member of the superfamily of insulins
European Journal of Biochemistry

A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF
The EMBO Journal

Prophenoloxidase activation is not required for survival to microbial infections in Drosophila
EMBO reports

Isolation and structural characterization of an insulin-related molecule, a predominant neuropeptide from Locusta migratoria
European Journal of Biochemistry

A serpin mutant links Toll activation to melanization in the host defence of Drosophila
The EMBO Journal

Virulence factors of the human opportunistic pathogen Serratia marcescens identified by in vivo screening
The EMBO Journal

Antimicrobial peptide defense in Drosophila
BioEssays

A novel insect defensin mediates the inducible antibacterial activity in larvae of the dragonfly Aeschna cyanea (Paleoptera, Odonata)
European Journal of Biochemistry

PVF2, a PDGF/VEGF-like growth factor, induces hemocyte proliferation in Drosophila larvae
EMBO reports

Metchnikowin, a Novel Immune-Inducible Proline-Rich Peptide from Drosophila with Antibacterial and Antifungal Properties
European Journal of Biochemistry

Characterization and transcriptional profiles of a Drosophila gene encoding an insect defensin
European Journal of Biochemistry

Insect immunity. Isolation of cDNA clones corresponding to diptericin, an inducible antibacterial peptide from Phormia terranovae (Diptera)
European Journal of Biochemistry

Mode of action of diptericin A, a bactericidal peptide induced in the hemolymph of Phormia terranovae larvae
Archives of Insect Biochemistry and Physiology


Bruce A. Beutler

Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6
British Journal of Haematology

New frontiers in immunology
EMBO reports

An essential role for Rxrα in the development of Th2 responses
European Journal of Immunology

Antagonism between MyD88- and TRIF-dependent signals in B7RP-1 up-regulation
European Journal of Immunology

Identification of a TLR4- and TRIF-dependent activation program of dendritic cells
European Journal of Immunology

Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases
Immunological Reviews

Neo-ligands for innate immune receptors and the etiology of sterile inflammatory disease
Immunological Reviews

Mechanism of pathogen-specific TLR4 activation in the mucosa: Fimbriae, recognition receptors and adaptor protein selection
European Journal of Immunology

The Rab27a Effectors JFC1/Slp1 and Munc13-4 Regulate Exocytosis of Neutrophil Granules
Traffic

Estimation of Physical Distance in the Genome through Probabilistic Analysis of Marker Density and Yeast Artificial Chromosome (YAC) Size
Biometrical Journal

R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells
European Journal of Immunology

Professor Dan Shechtman was awarded the 2011 Nobel Prize in Chemistry for his discovery of quasicrystals.

Dan Shechtman

Foreword by the Guest Editors
Israel Journal of Chemistry

 

The Royal Swedish Academy of Sciences has awarded the Nobel Prize in Physics with one half to Professor Saul Perlmutter and the other half equally to Professors Brian P. Schmidt and Adam G. Riess for the discovery of the accelerating expansion of the Universe through observations of distant supernovae.

Saul Perlmutter

Decadal variations in the global atmospheric land temperatures
Journal of Geophysical Research: Atmospheres

 


Brian P. Schmidt

Enterprise scale portfolio analysis at the national oceanic and atmospheric administration (NOAA)
Systems Engineering

 

The Sveriges Riksbank Prize in Economic Sciences in Memory of Alfred Nobel 2011 was awarded jointly to Thomas J. Sargent and Christopher A. Sims "for their empirical research on cause and effect in the macroeconomy"

Christopher A. Sims

Comment by Christopher A. Sims on ‘to criticize the critics’, by Peter C. B. Phillips
Journal of Applied Econometrics

Error Bands for Impulse Responses
Econometrica

Discussion
The Journal of Finance

The Nobel Peace Prize 2011 was awarded jointly to Ellen Johnson Sirleaf, Leymah Gbowee and Tawakkol Karman "for their non-violent struggle for the safety of women and for women's rights to full participation in peace-building work".

Leymah Gbowee

Nonviolence and Peacemaking
The Ecumenical Review

Effecting Change through Women's Activism in Liberia
IDS Bulletin