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Mast Cells and Basophils: Development, Activation and Roles in Allergic / Autoimmune Disease

Derek J. Chadwick (Editor), Jamie A. Goode (Editor)
ISBN: 978-0-470-01312-0
274 pages
November 2005
Mast Cells and Basophils: Development, Activation and Roles in Allergic / Autoimmune Disease (0470013125) cover image


The book presents recent advances relating to the factors and mechanisms that regulate the growth, differentiation and function of mast cells and basophils; discussion of new technologies used to study these cells, and integration of the basic scientific findings in the context of therapeutic possibilities for the treatment of diseases such as allergic inflammation and autoimmune disease which are mediated, in part, by these granulocytes.
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Table of Contents

Symposium on Mast cells and basophils: development, activation and roles in allergic/autoimmune disease, held at the Novartis Foundation, London, 16–18 November 2004
Editors: Derek J. Chadwick (Organizer) and Jamie Goode
This symposium was based on a proposal made by Santa Jeremy Ono.

Santa Jeremy Ono: Chair’s Introduction.

Yukihiko Kitamura MITF and SgIGSF: an essential transcription factor and its target adhesion molecule for development and survival of mast cells

Paul J. Bryce, Mendy L. Miller, Ichiro Miyajima, Mindy Tsai, Stephen J. Galli and Hans C. Oettgen: Immune sensitization in the skin is enhanced by antigen-independent effects of IgE on mast cells

Yasuko Furumoto, Gregorio Gomez, Claudia Gonzalez-Espinosa, Martina Kovarova, Sandra Odom, John J. Ryan and Juan Rivera: The role of Src family kinases in mast cell effector function

Richard L. Stevens, Nasa Morokawa, Jing Wang and Steven A. Krilis: RasGRP4 in mast-cell signalling and disease susceptibility

J. Abramson, E. A. Barbu and I. Pecht: Regulation of mast cell secretory response to the type I Fce receptor: inhibitory elements and desensitization

General discussion I.

Toshiaki Kawakami, Jiro Kitaura, Wenbin Xiao and Yuko Kawakami: IgE regulation of mast cell survival and function

See-Ying Tam, Janet Kalesnikoff, Susumu Nakae, Mindy Tsai and Stephen J. Galli: RabGEF1, a negative regulator of Ras signalling, mast cell activation and skin inflammation

Masako Toda, Takao Nakamura, Masaharu Ohbayashi, Yoshifumi Ikeda, Maria Dawson, Ricardo Micheler Richardson, Andrew Alban, Benjamin Leed, Dai Miyazaki and Santa Jeremy Ono: Role of CC chemokines and their receptors in multiple aspects of mast cell biology: comparative protein profiling of FceRI- and/or CCR1-engaged mast cells using protein chip technology

General discussion II.

Shigeo Koyasu, Akiko Minowa, Yasuo Terauchi, Takashi Kadowaki and Satoshi Matsuda: The role of phosphoinositide-3-kinase in mast cell homing to the gastrointestinal tract

K. Frank Austen: The mast cell and the cysteinyl leukotrienes

Silvia Monticelli, K. Mark Ansel, Dong U. Lee and Anjana Rao: Regulation of gene expression in mast cells: micro-RNA expression and chromatin structural analysis of cytokine genes

Cellina Cohen-Saidon and Ehud Razin: The involvement of Bcl-2 in mast cell apoptosis

General discussion III.

P. A. Nigrovic and D. M. Lee: Mast cells in autoantibody responses and arthritis

Greg D. Gregory, Allison Bickford, Michaela Robbie-Ryan, Mindy Tanzola and Melissa A. Brown: MASTering the immune response: mast cells in autoimmunity

Dean D. Metcalfe: Mastocytosis

Index of Contributors.

Subject Index.

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"This is an excellent resource for clinicians or basic scientists with an interest in mast cells and related diseases." (Doody's Health Services)
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