The hERG Cardiac Potassium Channel: Structure, Function and Long QT Syndrome, Novartis Foundation Symposium, No. 266
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Other Available Formats: Hardcover
It features regulatory authority perspectives on preferred preclinical test systems and includes topics on hERG channel gating, regulation of functional expression, pharmacological properties of hERG/IKr channels, drug-induced long QT syndrome and preclinical evaluation and regulatory recommendations for assessing QT prolongation risks.
Better understanding of the role of the hERG channel in drug-induced cardiac arrhythmias should ultimately lead to the development of important, new and safer medicines.