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Innate Immunity to Pulmonary Infection

Derek J. Chadwick (Editor), Jamie A. Goode (Editor)
ISBN: 978-0-470-02656-4
238 pages
January 2007
Innate Immunity to Pulmonary Infection (0470026561) cover image


Part of the prestigious Novartis Foundation series, this volume uniquely addresses the use of innate immunity to treat or prevent infectious diseases of the lung.

Innate Immunity to Pulmonary Infection:

  • Provides a comprehensive overview of pulmonary infectious diseases, including basic pathology, current and potential therapies, and detailed consideration of the innate biological resistance mechanisms in the lung
  • Thoroughly examines the major topic of innate immunity in immunology, which is now seen as key to the pathogenesis of and vaccination strategies for infectious diseases
  • Describes the genetic and environmental factors which determine the outcome of infection, such as latency of Tuberculosis, blood stream invasion from local infection, and local target tissue damage
  • Covers the roles of cells such as neutrophils, macrophages and dendritic cells and of molecular components such as Toll-like receptors
  • Discusses the clinical applications of the new knowledge regarding innate immunity and how this can be used in both treatment and prevention (vaccination) strategies
  • Includes contributions from an international and interdisciplinary group of experts

Innate Immunity to Pulmonary Infection is an essential resource for researchers in both industry and academia. It is of interest for all those interested in the disciplines of immunology, virology, biology, biotechnology and genetics.

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Table of Contents

Symposium on Innate immunity to pulmonary infection, held at the Wolfson Pavillion, University of Cape Town Medical School, South Africa, 28-30 November 2005.

Editors: Derek J. Chadwick (Organizer) and Jamie Goode.

This symposium is based on a proposal made by Siamon Gordon and Gordon Brown.

Chair's introduction (Siamon Gordon).

Lung diseases in South Africa: an overview (Eric D. Bateman and Anamika Jithoo).


TB epidemiology and human genetics (Paul D. van Helden, Marlo Moller, Chantal Babb, Robin Warren, Gerhard Walzl, Pieter Uys and Eileen Hoal).


Bacterial infections of the lung in normal and immunodeficient patients (David P. Speert).


Pathogenesis of avian flu H5N1 and SARS (Malik Peiris).


Immunity and tolerance to Aspergillus fumigatus (Claudia Montagnoli, Silvia Bozza, Roberta Gaziano, Teresa Zelante, Pierluigi Bonifazi, Francesca Sepioni, Silvia Bellocchio, Lucia Pitzurra and Luigina Romani).


Pentraxins in innate immunity and inflammation (Cecilia Garlanda, Barbara Bottazzi, Giovanni Salvatori, Rita De Santis, Alessia Cotena, Livija Deban, Viriginia Maina, Federica Moalli, Andrea Doni and Alberto Mantovani).


How superoxide production by neutrophil leukocytes kills microbes (Anthony W. Segal).


Linking innate to adaptive immunity through dendritic cells (Ralph M. Steinman).


Macrophage receptors and innate immunity: insights from dectin-1 (Gordon D. Brown).


Toll-like receptors and control of mycobacterial infection in mice (Bernhard Ryffel, Muazzam Jacobs, Shreemanta Parida, Tania Botha, Dieudonnée Togbe and Valerie Quesniaux).


Population of lungs by mast cells (T. J. Williams and C. L. Weller).


Innate immunity and mucus structure and function (John K. Sheehan, Mehmet Kesimer and Raymond Pickles).


Collectins and host defence (R. B. Sim, H. Clark, K. Hajelaand K. R. Mayilyan).


Infections and asthma pathogenesis: a critical role for dendritic cells? (Bart N. Lambrecht and Leonie S. van Rijt).


Innate and adaptive immunity in lung cancer (L. A. Vella and O. J. Finn).


Summing up (Siamon Gordon).

Index of Contributors.

Subject index.

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Author Information

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
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"…substantially elucidating recent basic science observations of potentially remarkable importance in understanding human biology." (Doody's Health Services)
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