Mitochondrial Biology: New Perspectives
Mitochondria have been strongly implicated in neurodegenerative diseases such as Parkinson’s, Huntington’s and amyotrophic lateral sclerosis. They are also affected in cancer, ageing and cardiovascular disease. The final section of the book reviews mitochondrial mutations and their consequences in ageing and other phenotypic manifestations. The authors discuss how mitochondrial proteins might constitute important therapeutic targets and describe initial attempts to develop compounds that can regulate their function.
Editors: Derek J. Chadwick (Organizer) and Jamie Goode.
This symposium is based on a proposal by Michael Duchen.
David G. Nicholls Chair's introduction.
Albert Neutzner, Richard J. Youle and Mariusz
Karbowski, Outer mitochondrial membrane protein degradation by
Sarah E. Haigh, Gilad Twig, Anthony A. J. Molina, Jakob D.
Wikstrom, Motti Deutsch and Orian S. Shirihai
PA-GFP: a window into the subcellular adventures of the individual
Luca Scorrano, Multiple functions of mitochondria-shaping proteins. Discussion.
Bruce M. Spiegelman, Transcriptional control of
mitochondrial energy metabolism through the PGC1
Charles Affourtit, Paul G. Crichton, Nadeene Parker and
Martin D. Brand, Novel uncoupling proteins.
Cecilia Giulivi, Mitochondria as generators and targets of nitric oxide. Discussion.
György Hajnóczky, Masao Saotome, György
Csordás, David Weaver and Muqing Yi, Calcium
signalling and mitochondrial motility.
Anna Romagnoli, Paola Aguiari, Diego De Stefani, Sara
Leo, Saverio Marchi, Alessandro Rimessi, Erika Zecchini,
Paolo Pinton and Rosario Rizzuto, Endoplasmic
reticulum/mitochondria calcium cross-talk.
Brian O’Rourke, Sonia Cortassa, Fadi Akar and
Miguel Aon, Mitochondrial ion channels in cardiac function
Paolo Bernardi and Michael Forte, The
mitochondrial permeability transition pore.
Dominic James, Philippe A. Parone, Olivier Terradillos,
Safa Lucken-Ardjomande, Sylvie Montessuit and Jean-Claude
Martinou, Mechanisms of mitochondrial outer membrane
M. Flint Beal, Mitochondria and neurodegeneration.
Mügen Terzioglu and Nils-Göran Larsson,
Mitochondrial dysfunction in mammalian ageing.
Eric A. Schon and Salvatore DiMauro. Mitochondrial
mutations: genotype to phenotype.
Chairman: David G Nicholls, Buck Institute for Age Research, Novato, USA.