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Applied Biostatistics for the Health Sciences

ISBN: 978-0-470-14764-1
664 pages
December 2009
Applied Biostatistics for the Health Sciences (0470147644) cover image


An authoritative, yet accessible, introduction to essential key methods used in the statistical analysis of data in the health sciences

Applied Biostatistics for the Health Sciences successfully introduces readers to the basic ideas and modeling approaches used in biostatistics through both step-by-step explanations and the use of data from the latest research in the field. By focusing on the correct use and interpretation of statistics rather than computation, this book covers a wide range of modern statistical methods without requiring a high level of mathematical preparation.

The book promotes a primary emphasis on the correct usage, interpretation, and conceptual ideas associated with each presented concept. The author begins with a discussion of basic biostatistical methods used to describe sample data arising in biomedical or health-related studies. Subsequent chapters explore numerous modeling approaches used with biomedical and health care data, including simple and multiple regression, logistic regression, experimental design, and survival analysis, Combined with a focus on the importance of constructing and implementing well-designed sampling plans, the book outlines the importance of assessing the quality of observed data, collecting quality data, and using confidence intervals in conjunction with hypothesis and significance tests.

Composed of extensively class-tested material, the book contains numerous pedagogical features that assist readers with a complete understanding of the presented concepts.  Key  formulae, procedures, and definitions are highlighted in enclosed boxes, and a glossary at the end of each chapter reviews key terminology and ideas. Worked-out examples and exercises illustrate important concepts and the proper use of statistical methods using MINITAB® output, and the examples in each section showcase the relevance of the discussed topics in modern research. A related Web site houses all of the data related to the book’s case studies and exercises.

Applied Biostatistics for the Health Sciences is an excellent introductory book for health science and biostatistics courses at the undergraduate and graduate levels. It is also a valuable resource for practitioners and professionals in the fields of pharmacy, biochemistry, nursing, health care informatics, and the applied health sciences.

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Table of Contents


Chapter 1 Introduction to Biostatistics.

1.1 What is Biostatistics?

1.2 Populations, Samples, and Statistics.

1.3 Clinical Trials.

1.4 Data Set Descriptions.



Chapter 2 Describing Populations.

2.1 Populations and Variables.

2.2 Population Distributions and Parameters.

2.3 Probability.

2.4 Probability Models.



Chapter 3 Random Sampling.

3.1 Obtaining Representative Data.

3.2 Commonly Used Sampling Plans.

3.3 Determining the Sample Size.



Chapter 4 Summarizing Random Samples.

4.1 Samples and Inferential Statistics.

4.2 Inferential Graphical Statistics.

4.3 Numerical Statistics for Univariate Datasets.

4.4 Statistics for Multivariate Data Sets.



Chapter 5 Measuring the Reliability of Statistics.

5.1 Sampling Distributions.

5.2 The Sampling Distribution of a Sample Proportion.

5.3 The Sampling Distribution of x .

5.4 Comparisons Based on Two Samples.

5.5 Bootstrapping the Sampling Distribution of a Statistic.



Chapter 6 Confidence Intervals.

6.1 Interval Estimation.

6.2 Confidence Intervals.

6.3 Single Sample Confidence Intervals.

6.4 Bootstrap Confidence Intervals.

6.5 Two Sample Comparative Confidence Intervals.



Chapter 7 Testing Statistical Hypotheses.

7.1 Hypothesis Testing.

7.2 Testing Hypotheses about Proportions.

7.3 Testing Hypotheses about Means.

7.4 Some Final Comments on Hypothesis Testing.



Chapter 8 Simple Linear Regression.

8.1 Bivariate Data, Scatterplots, and Correlation.

8.2 The Simple Linear Regression Model.

8.3 Fitting a Simple Linear Regression Model.

8.4 Assessing the Assumptions and Fit of a Simple Linear Regression Model.

8.5 Statistical Inferences based on a Fitted Model.

8.6 Inferences about the Response Variable.

8.7 Some Final Comments on Simple Linear Regression.



Chapter 9 Multiple Regression.

9.1 Investigating Multivariate Relationships.

9.2 The Multiple Linear Regression Model.

9.3 Fitting a Multiple Linear Regression Model.

9.4 Assessing the Assumptions of a Multiple Linear Regression Model.

9.5 Assessing the Adequacy of Fit of a Multiple Regression Model.

9.6 Statistical Inferences Based Multiple Regression Model.

9.7 Comparing Multiple Regression Models.

9.8 Multiple Regression Models with Categorical Variables.

9.9 Variable Selection Techniques.

9.10 Some Final Comments on Multiple Regression.



Chapter 10 Logistic Regression.

10.1 Odds and Odds Ratios.

10.2 The Logistic Regression Model.

10.3 Fitting a Logistic Regression Model.

10.4 Assessing the Fit of a Logistic Regression Model.

10.5 Statistical Inferences Based on a Logistic Regression Model.

10.6 Variable Selection.

10.7 Some Final Comments on Logistic Regression.



Chapter 11 Design of Experiments.

11.1 Experiments versus Observational Studies.

11.2 The Basic Principles of Experimental Design.

11.3 Experimental Designs.

11.4 Factorial Experiments.

11.5 Models for Designed Experiments.

11.6 Some Final Comments of Designed Experiments.



Chapter 12 Analysis of Variance.

12.1 Single-Factor Analysis of Variance.

12.2 Randomized Block Analysis of Variance.

12.3 Multifactor Analysis of Variance.

12.4 Selecting the Number of Replicates in Analysis of Variance.

12.5 Some Final Comments on Analysis of Variance.



Chapter 13 Survival Analysis.

13.1 The Kaplan Meier Estimate of the Survival Function.

13.2 The Proportional Hazards Model.

13.3 Logistic Regression and Survival Analysis.

13.4 Some Final Comments on Survival Analysis.




Appendix A.

Problem Solutions.


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Author Information

Richard J. Rossi, PhD, is Professor and Head of the Department of Mathematical Sciences at Montana Tech of the University of Montana. He has previously served as president of the Montana Chapter of the American Statistical Association (1996 and 2001) and as associate editor for Biometrics. Dr. Rossi has published journal articles in his areas of research interest, which include nonparametric density estimation, finite mixture models, and computational statistics.¿He is the author of Theorems, Corollaries, Lemmas, and Methods of Proof, also published by Wiley.
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The Wiley Advantage

  • Pedagogical features include formulas highlighted in text boxes and chapter summaries that highlight key vocabulary and concepts for the chapter
  • The text contains a great number of illustrations and graphs as well as text/formula boxes that contain the key formula, definitions, and concepts covered in each section
  • A large number of the examples are based on real-life studies published in biomedical and healthcare journals
  • Several topics that are not usually covered in a first course in biostatistics are included, such as bootstrapping, sampling, sample size computations for two sample confidence intervals and hypothesis tests, design of experiments, and survival analysis
  • An accompanying Web site provides data for the case studies and exercises that are contained in the text
  • Both MINITAB® and Microsoft® Office Excel® data files are provided for each data set
  • References are given to difficult problems that often occur when buidling and assessing a statistical model
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"The book is an excellent introduction to biostatistics. It is also a valuable resource for practitioners in all fields of health sciences." (Biometrical Journal, February 2011)

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