Combating the Threat of Pandemic Influenza: Drug Discovery Approaches

Preface.

1. Existing Influenza Antivirals: The Mechanisms of Action and Potential in the Face of Avian Influenza (Erik De Clercq).

2. Development of High-Throughput Screening Assays for Influenza (Diana L. Noah, E. Lucile White, and James W. Noah).

3. Mechanisms of IFN Resistance by Influenza Virus (Heather J. Ezelle and Bret A. Hassel).

4. Broadly Effective Anti-Respiratory Virus Agents (Shiro Shigeta).

5. Current Status on Development of Nucleic Acid-based Antiviral Drugs Against Influenza Virus Inefection (Jonathan P. Wong, Mary E. Christopher, Murray Cairns, L.-Q. Sun, Roderic M.K. Dale, and Andres M. Salazar).

6. Antiviral RNA Interface Strategies Targeting Influenza Virus and Other Respiratory Viruses (Joost Haasnoot and Ben Berkhout).

7. Promising Antiviral Glyco-molecules from an Edible Alga (Toshimitsu Hayashi, Kyoko Hayashi, Kenji Kanekiyo, Jung-Bum Lee, Takahisa Nakano, and Minoru Hashimoto).

8. Rational Design of an Anti-Adhesion Drug for Influenza (Nicolai V. Bovin and Alexandra S. Gambaryan).

9. Understanding Influenza Neuraminidase Inhibitors Using Quantitative Structure - Activity Relationship (QSAR) Models (Rajeshwar P. Verma and Corwin Hansch).

10. Peptide Inhibitors Targeting Virus-Cell Fusion in Class 1 Enveloped Viruses (George F. Gao).

11. Novel Influenza Therapeutics (Laura M. Aschenbrenner, Nicole Pelletier, Mang Yu, and Fang Fang).

Index.