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Bioinorganic Chemistry: A Short Course, 2nd Edition

ISBN: 978-0-470-19170-5
400 pages
October 2007
Bioinorganic Chemistry: A Short Course, 2nd Edition (0470191708) cover image
An updated, practical guide to bioinorganic chemistry

Bioinorganic Chemistry: A Short Course, Second Edition provides the fundamentals of inorganic chemistry and biochemistry relevant to understanding bioinorganic topics. Rather than striving to provide a broad overview of the whole, rapidly expanding field, this resource provides essential background material, followed by detailed information on selected topics. The goal is to give readers the background, tools, and skills to research and study bioinorganic topics of special interest to them. This extensively updated premier reference and text:
  • Presents review chapters on the essentials of inorganic chemistry and biochemistry
  • Includes up-to-date information on instrumental and analytical techniques and computer-aided modeling and visualization programs
  • Familiarizes readers with the primary literature sources and online resources
  • Includes detailed coverage of Group 1 and 2 metal ions, concentrating on biological molecules that feature sodium, potassium, magnesium, and calcium ions
  • Describes proteins and enzymes with iron-containing porphyrin ligand systems-myoglobin, hemoglobin, and the ubiquitous cytochrome metalloenzymes-and the non-heme, iron-containing proteins aconitase and methane monooxygenase
Appropriate for one-semester bioinorganic chemistry courses for chemistry, biochemistry, and biology majors, this text is ideal for upper-level undergraduate and beginning graduate students. It is also a valuable reference for practitioners and researchers who need a general introduction to bioinorganic chemistry, as well as chemists who want an accessible desk reference.
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Chapter 1: Inorganic Chemistry Essentials.

Introduction .

Essential Chemical Elements.

Metals in Biological Systems: A Survey.

Inorganic Chemistry Basics.

Biological Metal Ion Complexation.

Thermodynamics.

Kinetics.

Electronic and Geometric Structures of Metals in Biological Systems.

Bioorganometallic Chemistry.

Electron Transfer.

Introduction to Biological Metal Homeostasis, Transport, and Storage.

Chapter 2: Biochemistry Fundamentals.

Introduction.

Proteins.

Amino Acid Building Blocks.

Protein Structure.

Protein Sequencing and Proteomics.

Protein Function, Enzymes and Enzyme Kinetics.

Nucleic Acids.

DNA and RNA Building Blocks.

DNA and RNA Molecular Structures.

Transmission of Genetic Information.

Genetic Mutations and Site-Directed Mutagenesis.

Genes and Cloning.

Genomics and the Human Genome.

The ATP-binding cassette (ABC) Transporter Superfamily.

Chapter 3: Instrumental Methods.

Introduction.

Analytical Instrument-Based Methods.

Spectroscopy.

X-ray Absorption Spectroscopy (XAS) and Extended X-ray Absorption Fine Structure (EXAFS).

Theoretical Aspects and Hardware.

Descriptive Examples.

X-ray Crystallography.

Introduction.

Crystallization and Crystal Habits.

Theory and Hardware.

Descriptive Examples.

Electron Paramagnetic Resonance.

Theory and Determination of g-values.

Hyperfine and Superhyperfine Interactions.

Descriptive Examples.

Nuclear Magnetic Resonance.

Theoretical Aspects.

Nuclear Screening and the Chemical Shift.

Spin-Spin coupling.

Techniques of Spectral Integration and Spin-Spin Decoupling.

Nuclear Magnetic Relaxation.

The nuclear Overhauser Effect (NOE).

Obtaining the NMR spectrum.

Two-dimensional NMR Spectroscopy.

Correlation Spectroscopy (COSY).

Nuclear Overhauser Effect Spectroscopy (NOESY).

Descriptive Examples.

Mössbauer Spectroscopy.

Theoretical Aspects.

Quadrupole Splitting and the Isomer Shift.

Magnetic Hyperfine Interactions.

Descriptive Examples.

Atomic Force Microscopy.

Fast Methods.

Stopped-Flow Kinetic Methods.

Flash Photolysis.

Time-Resolved Crystallography.

Chapter 4: Introduction to Computer-Based Methods.

Computer Hardware .

Molecular Modeling and Molecular Mechanics.

Introduction to MM.

Molecular Modeling, Molecular Mechanics and Molecular Dynamics.

Biomolecule Modeling.

Molecular Modeling Descriptive Examples.

Quantum Mechanics-Based Computational Methods.

Introduction.

Ab-initio Methods.

Density Functional Theory.

Semi-empirical Methods.

Computer Software for Chemistry.

Mathematical Software.

World Wide Web Online Resources.

Nomenclature and Visualization Resources.

Online Societies, Literature, Materials, Equipment Webservers.

Chapter 5: Group I and II metals in biological systems.

Transport and storage of metal ions.

Homeostasis involving Na+, K+, Ca2+, Mg2+, Zn2+ (as well as P, Cl, and H).

Movement of molecules and ions across membranes.

Proton pumps.

Ion pumps.

Active versus passive transport .

Na+/ K+ ATPases.

Magnesium dependent biomolecules.

Kinases.

ATP-pumps.

Catalytic RNA and Magnesium.

Magnesium in chlorophyll.

Calcium dependent biomolecules.

Calmodulins and triggering.

Biochemistry of nitrogen oxides, nitroxyl, and peroxynitrite ion.

Chapter 6: Iron Containing Proteins and Enzymes.

Iron-containing proteins with porphyrin ligand systems.

Hemoglobin and Myoglobin (first edition material somewhat condensed).

Cytochrome P-450: a monooxygenase.

Iron-containing cytochromes in photosynthesis.

Green plant cytochromes.

Cytochrome bc559.

Cytochrome bf.

Bacterial cytochromes.

Cytochrome c2.

Cytochrome bc1.

Iron-containing cytochromes in the respiratory pathway.

Cytochrome c.

Cytochrome c oxidase.

Non-Heme Iron-containing proteins.

MMO-Methane Monooxygenase.

Catechol dioxygenases.

Iron-oxo clusters.

Transferrin for metal transport .

Ferritin for metal storage.

Hemerythrin.

Purple acid phosphatase.

Iron-sulfur cluster proteins.

Rubredoxin.

Ferrodoxins.

Aconitase.

Chapter 7: Enzymes containing zinc, nickel, and enzymes with multiple metal cofactors.

Zinc homeostasis, transport, and storage.

Zinc Enzymes.

Alkaline phosphatase.

Alcohol dehydrogenase.

Aspartate transcarbamoylase.

Carbonic anhydrase.

Carboxypeptidase A and B.

Zinc Fingers.

Nickel Enzymes.

Urease.

F430.

Enzymes with multiple metal cofactors.

Hydrogenases.

Carbon monoxide dehydrogenases.

Chapter 8 Disease, Disease Diagnosis and Treatment Utilizing Inorganic Species.

Metal Transport and Metallochaperones.

Disease States.

Metal deficiency.

Metal toxicity.

Copper toxicity.

FALS.

Wilson and Menkes diseases.

Disease Diagnosis.

Technetium Imaging Agents.

Gadolinium MRI Imaging Agents.

Quantum Dots for In vivo Imaging.

Metals in Medicine.

Manganese superoxide mimetics.

Vanadium-based Diabetes Drugs.

Platinum-containing Anticancer Agents.

Nanomedicine.

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Rosette M. Roat-Malone, PhD, is Adjunct Professor of Chemistry at Washington College in Chestertown, Maryland. She developed the advanced bioinorganic chemistry course that formed the basis for this book's predecessor, Bioinorganic Chemistry: A Short Course. Her research in the reactions of platinum coordination compounds used as anticancer agents with biological molecules has been supported by the National Science Foundation, the Petroleum Research Fund, and the Research Corporation.

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KEY FEATURES
  • Differs from its competitors by focusing on a select number of specialized bioinorganic topics of interest to students and researchers and develops them in great detail, rather than providing a general, comprehensive survey across all of bioinorganic chemistry. As a result, this is a more manageable and accessible text than other introductions to the field.
  • Extensive material on computer modeling and medicinal chemistry not found in other books.
  • Includes 8-page color insert.

OTHER FEATURES

  • Presents comprehensive, up-to-date primary references for the specific bioinorganic areas covered.
  • Offers detailed information on instrumental and analytical techniques used in discussions of the specific bioinorganic areas covered.  
  • Provides guidance on computer hardware, software, molecular drawing, design, and modeling programs and extensive listings of world wide web addresses of interest.
  • Treats the area of inorganic species used in the diagnosis and treatment of diseases in more comprehensive fashion than competitors.
  • Contains useful study problems and current bibliographic references
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"Roat-Malone has done a great job updating the content and including references as recent as 2006 in this second edition." (CHOICE, May 2008)
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