1 Modeling and Informatics in Drug Design (Prasad V. Bharatam, Smriti Khanna, and Sandrea M. Francis).

2 Computer Techniques: Identifying Similarities Between Small Molecules (Peter Meek, Guillermo Moyna, and Randy Zauhar).

3 Protein–Protein Interactions (Kamaljit Kaur, Dipankar Das, and Mavanur R. Suresh).

4 Method Development for Preclinical Bioanalytical Support (Masood Khan and Naidong Weng).

5 Analytical Chemistry Methods: Developments and Validation (Izet M. Kapetanovic and Alexander V. Lyubimov).

6 Chemical and Physical Characterizations of Potential New Chemical Entity (Adegoke Adeniji and Adeboye Adejare).

7 Permeability Assessment (Srinivas Ganta, Puneet Sharma, and Sanjay Garg).

8 How and Where Are Drugs Absorbed? (Marival Bermejo and Isabel Gonzalez-Alvarez).

9 Absorption of Drugs after Oral Administration (Luis Granero and Ana Polache).

10 Distribution: Movement of Drugs through the Body (Jayanth Panyam and Yogesh Patil).

11 The Blood–Brain Barrier and Its Effect on Absorption and Distribution (A. G. de Boer and P. J. Gaillard).

12 Transporter Interactions in the ADME Pathway of Drugs (Yan Zhang and Donald W. Miller).

13 Accumulation of Drugs in Tissues (Krishnamurthy Venkatesan, Deepa Bisht, and Mohammad Owais).

14 Salt and Cocrystal Form Selection (Ann W. Newman, Scott L. Childs, and Brett A. Cowans).

15 Dissolution (A.K. Tiwary, Bharti Sapra, and Subheet Jain).

16 Stability: Physical and Chemical (Eric M. Gorman, Brian E. Padden, and Eric J. Munson).

17 Dosage Formulation (Alexander V. Lyubimov).

18 Cytochrome P450 Enzymes (Eugene G. Hrycay and Stelvio M. Bandiera).

19 Metabolism Kinetics (Charles W. Locuson and Timothy S. Tracy).

20 Drug Clearance (Sree D. Panuganti and Craig K. Svensson).

21 In Vitro Metabolism in Preclinical Drug Development (Olavi Pelkonen, Ari Tolonen, Miia Turpeinen, and Jouko Uusitalo).

22 Utilization of In Vitro Cytochrome P450 Inhibition Data for Projecting Clinical Drug–Drug Interactions (Jane R. Kenny, Dermot F. McGinnity, Ken Grime, and Robert J. Riley).

23 In Vivo Metabolism in Preclinical Drug Development (Sevim Rollas).

24 In Vitro Evaluation of Metabolic Drug–Drug Interactions: Scientific Concepts and Practical Considerations (Albert P. Li).

25 Mechanisms and Consequences of Drug–Drug Interactions (Dora Farkas, Richard I. Shader, Lisa L. von Moltke, and David J. Greenblatt).

26 Species Comparison of Metabolism in Microsomes and Hepatocytes (Niels Krebsfaenger).

27 Metabolite Profi ling and Structural Identifi cation (Mehran F. Moghaddam).

28 Linkage between Toxicology of Drugs and Metabolism (Ruiwen Zhang and Elizabeth R. Rayburn).

29 Allometric Scaling (William L. Hayton and Teh-Min Hu).

30 Interrelationship between Pharmacokinetics and Metabolism (James W. Paxton).

31 Experimental Design Considerations in Pharmacokinetic Studies (William W. Hope, Vidmantas Petraitis, and Thomas J. Walsh).

32 Bioavailability and Bioequivalence Studies (Alexander V. Lyubimov and Ihor Bekersky).

33 Mass Balance Studies (Jan H. Beumer, Julie L. Eiseman, and Merrill J. Egorin).

34 Pharmacodynamics (Beom Soo Shin, Dhaval Shah, and Joseph P. Balthasar).

35 Physiologically Based Pharmacokinetic Modeling (Harvey J. Clewell III, Micaela B. Reddy, Thierry Lave, and Melvin E. Andersen).

36 Mathematical Modeling as a New Approach for Improving the Effi cacy/Toxicity Profi le of Drugs: The Thrombocytopenia Case Study (Zvia Agur, Moran Elishmereni, Yuri Kogan, Yuri Kheifetz, Irit Ziv, Meir Shoham, and Vladimir Vainstein).

37 Regulatory Requirements for INDs/FIH (First in Human) Studies (Shayne Cox Gad).

38 Data Analysis (Jayesh Vora and Pankaj B. Desai).

Index.