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Phycotoxins: Chemistry and Biochemistry

Luis M. Botana (Editor)
ISBN: 978-0-470-27658-7
368 pages
February 2008, Wiley-Blackwell
Phycotoxins: Chemistry and Biochemistry (0470276584) cover image
Phycotoxins: Chemistry and Biochemistry presents the most updated information available on phycotoxins. Major emphases are given to chemistry and biochemistry, while minor emphases are given to the aspects of origin, toxicology, or analytical methodology. The book discusses 16 phycotoxins, 7 on those affecting the nervous systems, 4 affecting other body systems; and 4 with undefined targets.


An alphabetical listing of toxins presented includes: Azaspiracids; Brevetoxins; Cyanobacterial toxins; Domoic acid; Gambierols; Gymnodimines, prorocentrolides, spirolides, pinnatoxins and cyclic imines in general; Maitotoxin; Okadaic acid and dinophysistoxins; Palytoxins and ostreocins; Pectenotoxins; Polycavernosides; and Yessotoxins. In addition, several mechanistic aspects of newer or emerging toxins are covered such as amphidinols or gymnocine. Information presented and coverage of each toxin follows the following distribution: background and toxicology (10%); chemistry, biochemistry and metabolism (75%); mechanism of action (10%); and analytical methodology (5%).


The detailed information on chemistry in Phycotoxins: Chemistry and Biochemistry provides investigators, regulators, food technologists and toxicologists an updated basis on which research in other areas such as toxicology, mechanism of action, analytical methodology and pharmacology can be successfully developed and expanded.

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1. Gambierols (Makoto Sasaki, Eva Cagide, and Carmen Louzao).

2. Brevetoxins: Structure, Toxicology and Origin (Ambrose Furey, Keith O’Callaghan, Javier García Fernández, Mary Lehane, Mónica Fernández Amandi, and Kevin J. James).

3. Chemistry of Maitotoxin (Masayuki Satake).

4. Biochemistry of Maitotoxin (Laura A. de la Rosa, Emilio Alvarez-Parrilla, and Alejandro Martínez).

5. The Chemistry of Palytoxins and Ostreocins (Panagiota Katikou).

6. Biochemistry of Palytoxins and Ostreocins (Carmen Vale and Isabel R. Ares).

7. Chemistry of Cyanobacterial Neurotoxins – Anatoxin-a: Synthetic Approaches (Nuria Armesto Arbella, Keith O’Callaghan, Ambrose Furey, and Kevin J. James).

8. Anatoxin-a and Analogues: Discovery, Distribution and Toxicology (Kevin J. James, Janet Crowley, Mary Lehane, and Ambrose Furey).

9. Pectenotoxins (Christopher Miles).

10. Chemistry, Orgins and Distribution of Yessotoxin and its Analogues (Philipp Hess and John A.B. Aasen).

11. Pharmacology of Yessotoxin (Amparo Alfonso and Carmen Alfonso).

12. Chemistry of Diarrhetic Shellfish Poisoning Toxins (Paulo Vale).

13. The Molecular and Integrative Basis to Domoic Acid Toxicity (John Ramsdell).

14. Hepatotoxic Cyanobacteria (Ana Gago).

15. Polycavernosides (Leo A. Paquette and Mari Yamashita.

16. Structural Assignment and Total Synthesis of Azaspiracid-1 (K.C. Nicolaou, Michael O. Frederick, Kevin P. Cole, Goran Petrovic, and Eriketi Loizidou).

17. Biochemistry of Azaspiracid Poisoning Toxins (Natalia Vilariño).

18. The Cyclic Imines: An Insight into this Emerging Group of Bioactive Marine Toxins (Jordi Molgo and Emmanuelle Girard, and Evelyne Benoit).

Index.

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Editor: Dr. Luis M Botana is professor of Pharmacology, University of Santiago de Compostela, Spain. His group is a world leader in the development of new methods to monitor the presence of phycotoxins, having developed methods to date for saxitoxins, yessotoxin, pectenotoxin, ciguatoxins, brevetoxins, okadaic acid and dinophysistoxins Dr. Botana is the editor of Seafood and Freshwater Toxins: Pharmacology, Physiology and Detection, to date the only comprehensive reference book entirely devoted to marine toxins.
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  • Describes 16 phycotoxins as to chemistry, biochemistry, origin, toxicology, and analytical methodology
  • Coverage extends to mechanistic aspects of newer and emerging toxins
  • Updates research knowledge base for investigators, regulators, food technologists and toxicologists
  • Internationally respected editors and contributors
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"I would thoroughly recommend this invaluable text to Scientists." (BTS Newsletter)
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