Magnetic isotope effect studies have been found to be the most reliable way to study and define the mechanism by which a reaction occurs. Authored by the discoverer of the magnetic isotope effect, this book covers the basic physics and principles behind this effect to more practical applications across the various fields of chemistry, biochemistry, and geochemistry. Not only does the book shed light on MIE as a tool for studying reaction mechanisms, but it also details how to apply MIE to one s own research problems.