Applied Longitudinal Analysis, 2nd Edition
August 2011, ©2011
". . . [this book] should be on the shelf of everyone interested in . . . longitudinal data analysis."
Journal of the American Statistical Association
Features newly developed topics and applications of the analysis of longitudinal data
Applied Longitudinal Analysis, Second Edition presents modern methods for analyzing data from longitudinal studies and now features the latest state-of-the-art techniques. The book emphasizes practical, rather than theoretical, aspects of methods for the analysis of diverse types of longitudinal data that can be applied across various fields of study, from the health and medical sciences to the social and behavioral sciences.
The authors incorporate their extensive academic and research experience along with various updates that have been made in response to reader feedback. The Second Edition features six newly added chapters that explore topics currently evolving in the field, including:
Fixed effects and mixed effects models
Marginal models and generalized estimating equations
Approximate methods for generalized linear mixed effects models
Multiple imputation and inverse probability weighted methods
Smoothing methods for longitudinal data
Sample size and power
Each chapter presents methods in the setting of applications to data sets drawn from the health sciences. New problem sets have been added to many chapters, and a related website features sample programs and computer output using SAS, Stata, and R, as well as data sets and supplemental slides to facilitate a complete understanding of the material.
With its strong emphasis on multidisciplinary applications and the interpretation of results, Applied Longitudinal Analysis, Second Edition is an excellent book for courses on statistics in the health and medical sciences at the upper-undergraduate and graduate levels. The book also serves as a valuable reference for researchers and professionals in the medical, public health, and pharmaceutical fields as well as those in social and behavioral sciences who would like to learn more about analyzing longitudinal data.
Preface to First Edition.
Part I. Introduction to Longitudinal and Clustered Data.
1. Longitudinal and Clustered Data.
2. Longitudinal Data. Basic Concepts.
Part II. Linear Models for Longitudinal Continuous Data.
3. Overview of Linear Models for Longitudinal Data.
4. Estimation and Statistical Inference.
5. Modelling the Mean: Analyzing Response Profiles.
6. Modelling the Mean: Parametric Curves.
7. Modelling the Covariance.
8. Linear Mixed Effect Models.
9. Fixed Effects versus Random Effects Models.
10. Residual Analyses and Diagnostics.
Part III. Generalized Linear Models for Longitudinal Data.
11. Review of Generalized Linear Models.
12. Marginal Models: Introduction and Overview.
13. Marginal Models: Generalized Estimating Equations (GEE).
14. Generalized Linear Mixed Effects Models.
15. Generalized Linear Mixed Effects Models: Approximate Methods of Estimation.
16. Contrasting Marginal and Mixed Effects Models.
Part IV. Missing Data and Dropout.
17. Missing Data and Dropout: Overview of Concepts and Methods.
18. Missing Data and Dropout: Multiple Imputation and Weighting Methods.
Part V. Advanced Topics for Longitudinal and Clustered Data.
19. Smoothing Longitudinal Data: Semiparametric Regression Models.
20. Sample Size and Power.
21. Repeated Measures and Related Designs.
22. Multilevel Models.
Appendix A. Gentle Introduction to Vectors and Matrices.
Appendix B. Properties of Expectations and Variance.
Appendix C. Critical Points for a 50:50 Mixture of Chi-Squared Distributions.
Nan M. Laird, PhD, is Professor of Biostatistics at the Harvard School of Public Health. A Fellow of the American Statistical Association and Institute of Mathematical Sciences, she has published extensively in the areas of statistical genetics, longitudinal studies, missing or incomplete data, and analysis of multiple informant data.
James H. Ware, PhD, is Frederick Mosteller Professor of Biostatistics at the Harvard School of Public Health. A Fellow of the American Statistical Association and statistical consultant to the New England Journal of Medicine, he has made significant contributions to the development of statistical methods for the design and analysis of longitudinal studies.
“The text is well-organized and clearly written. It is accessible to researchers with varying levels of statistical expertise, with plenty of data examples that make reading and learning enjoyable. I recommend it to biostatisticians as well as to clinicians and other health researchers who may not have much statistical training . . . Applied Longitudinal Analysisis generally my first recommendation when asked for a valuable resource in the field due to the breadth of topics covered and its practical utility.” (Journal of Biopharmaceutical Statistics, 1 January 2013)
“The book also serves as a valuable reference for researchers and professionals in the medical, public health, and pharmaceutical fields, as well as those in social and behavioral sciences who would like to learn more about analysing longitudinal data.” (Zentralblatt MATH, 2012)"This book provides very broad coverage of modern methods for longitudinal data analysis from an applied perspective ... I highly recommend this book to statisticians and quantitative researchers who encounter longitudinal and/or clustered data. In addition, I think the book would be an excellent choice as the primary textbook in an applied longitudinal data course." (Journal of Biopharmaceutical Statistics, 2013)