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Biomarkers: In Medicine, Drug Discovery, and Environmental Health

ISBN: 978-0-470-45224-0
618 pages
October 2010
Biomarkers: In Medicine, Drug Discovery, and Environmental Health (0470452242) cover image
This book provides an introduction to the field of biomarkers, how they have been and can be used, and how different approaches can be used to identify, characterize, and monitor biomarkers. The book has chapters on topics including HIV, Cancer, Parkinson’s, vascular injury, environmental exposure. A following section discusses the technologies (diagnostics and assays) to detect biomarkers and authors have emphasized the preclinical and clinical manifestation of the injury/disease process.
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Preface.

Contributors.

1 Biomarkers: An Evolutionary Perspective (Michael Ferguson and Vishal Vaidya).

SECTION I: TOOLS FOR BIOMARKER DISCOVERY.

2 Genomics (Weida Tong and Donna L. Mendrick).

3 Proteomics for Biomarker Discovery (Timothy D. Veenstra).

4 Metabolic Profiling for Biomarker Discovery (Hector C. Keun).

5 The Bittersweet Promise of Glycobiology (Padmaparna Chaudhuri, Rania Harfouche, and Shiladitya Sengupta).

SECTION II: BIOMARKERS OF INJURY/DISEASE.

6 Biomarkers of Alzheimer's and Parkinson's Disease (Walter Maetzler and Daniela Berg).

7 Biomarkers of Cardiac Injury (Anthony S. McLean and Stephen J. Huang).

8 Lung Injury Biomarkers (Urmila P. Kodavanti).

9 Translational Biomarkers of Acute Drug-Induced Liver Injury: The Current State, Gaps and Future Opportunities (Josef Ozer, William Reagan, Sheli Schomaker, Joe Palandra, Mike Baratta and Shashi Ramaiah).

10 Biomarkers of Acute Kidney Injury (Frank Dieterle and Frank Sistare).

11 In Search of Biomarkers for Drug-Induced Vascular Injury (James R. Turk).

12 Biomarkers of Immunotoxicity (Rodney R. Dietert).

13 Biomarkers in Obstetric Medicine (Manish Maski, Sarosh Rana and S. Ananth Karumanchi.

14 Biomarkers in Cancer (Roopali Roy, Christine M. Coticchia, Jiang Yang and Marsha A. Moses).

15 Biomarkers of HIV (Lewis Kaufman and Michael J Ross).

16 Biomarkers of In Vitro Drug-Induced Mitochondrial Dysfunction (James A. Dykens and Yvonne Will).

SECTION III: TECHNOLOGY FOR BIOMARKER DETECTION.

17 Immunoassay-Based Technologies for the Measurement of Biological Materials Used for Biomarkers Discovery and Translational Research (Vincent Ricchiuti).

18 Nanoscale Techniques for Biomarker Quantification (Madhukar Varshney, and Harold G. Craighead).

19 Immunodiagnostics with a Focus on Lateral Flow Point-of-Care Devices (Roy R. Mondesire, Glen M. Ford, Hannie F. Ford, and Stephen C. Mefferd).

SECTION IV: HOT TOPICS IN BIOMARKER RESEARCH.

20 Biomarkers for Environmental Exposure (Jane E. Gallagher, Elaine A. Cohen Hubal and Stephen W. Edwards).

21 Clinical Study Design in Biomarker Research (Orfeas Liangos and Bertrand L. Jaber).

22 Statistical Issues in Biomarker Research (Daniel Holder and Matthew Schipper).

23 Regulatory Perspective for Biomarker Qualification from U.S. FDA (Federico Goodsaid).

24 The European Medicines Agency Approach (Marisa Papaluca Amati and Spiros Vamvakas).

Index.

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VISHAL S. VAIDYA, PhD, is an Assistant Professor of Medicine at Harvard Medical School in the Renal Division of Brigham and Women's Hospital. He directs the Laboratory of Kidney Toxicology and Regeneration with a research emphasis on discovery and evaluation of biomarkers and biosensors for early detection of kidney injury and investigates the molecular mechanisms of kidney tissue repair. Dr. Vaidya has authored more than thirty-five original research articles and twelve chapters and reviews. He serves as a councilor for the northeast chapter of the Society of Toxicology and is an elected member of Harvard School of Public Health's Center for Environmental Health. He is the recipient of the Pathway to Independence grant by the National Institute of Environmental Health Sciences.

JOSEPH V. BONVENTRE, MD, PhD, is the Samuel A. Levine Professor of Medicine at Harvard Medical School. He is also Chief of the Renal Division and Director of the Biomedical Engineering Division of Brigham and Women's Hospital and is President-elect of the American Society of Nephrology. He has authored more than 250 original papers and 120 chapters and reviews. His research focuses primarily on the study of kidney injury and repair and signal transduction, with special emphasis on the role of inflammation, biomarkers, and stem cells. Bonventre has received a MERIT award from the National Institute of Diabetes and Digestive and Kidney Diseases.

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"In summary, this book provides an excellent introduction and overview of discovery and application of biomarkers in medicine and drug discovery and development. The chapters are well structured, with plenty of literature references for further reading, and supplemented with links to web-based resources." (ChemMedChem, 2011)

"They cover tools for discovering biomarkers, biomarkers for injury or disease, technology for detecting biomarkers, and hot topics in biomarker research." (SciTech Book News, December 2010)"This book provides an introduction to the field of biomarkers, how they have been and can be used, and how different approaches can be used to identify, characterize, and monitor biomarkers." (News Blaze, 1 November 2010)

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