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Uncertainty Modeling in Dose Response: Bench Testing Environmental Toxicity

Roger M. Cooke
ISBN: 978-0-470-48139-4
E-book
256 pages
May 2009
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Acknowledgments.

Contributors.

Introduction (Roger M. Cooke and Margaret MacDonell).

1 Analysis of Dose–Response Uncertainty Using Benchmark Dose Modeling (Jeff Swartout).

Comment: The Math/Stats Perspective on Chapter 1: Hard Problems Remain (Allan H. Marcus).

Comment: EPI/TOX Perspective on Chapter 1: Re-formulating the Issues (Jouni T. Tuomisto).

Comment: Regulatory/Risk Perspective on Chapter 1: A Good Baseline (Weihsueh Chiu).

Comment: A Question Dangles (David Bussard).

Comment: Statistical Test for Statistics-as-Usual Confidence Bands (Roger M. Cooke).

Response to Comments (Jeff Swartout).

2 Uncertainty Quantification for Dose–Response Models Using Probabilistic Inversion with Isotonic Regression: Bench Test Results (Roger M. Cooke).

Comment: Math/Stats Perspective on Chapter 2: Agreement and Disagreement (Thomas A. Louis).

Comment: EPI/TOX Perspective on Chapter 2: What Data Sets Per se Say (Lorenz Rhomberg).

Comment: Regulatory/Risk Perspective on Chapter 2: Substantial Advances Nourish Hope for Clarity? (Rob Goble).

Comment: A Weakness in the Approach? (Jouni T. Tuomisto).

Response to Comments (Roger Cooke).

3 Uncertainty Modeling in Dose Response Using Nonparametric Bayes: Bench Test Results (Lidia Burzala and Thomas A. Mazzuchi).

Comment: Math/Stats Perspective on Chapter 3: Nonparametric Bayes (Roger M. Cooke).

Comment: EPI/TOX View on Nonparametric Bayes: Dosing Precision (Chao W. Chen).

Comment: Regulator/Risk Perspective on Chapter 3: Failure to Communicate (Dale Hattis).

Response to Comments (Lidia Burzala).

4 Quantifying Dose–Response Uncertainty Using Bayesian Model Averaging (Melissa Whitney and Louise Ryan).

Comment: Math/Stats Perspective on Chapter 4: Bayesian Model Averaging (Michael Messner).

Comment: EPI/TOX Perspective on Chapter 4: Use of Bayesian Model Averaging for Addressing Uncertainties in Cancer Dose–Response Modeling (Margaret Chu).

Comment: Regulatorary/Risk Perspective on Chapter 4: Model Averages, Model Amalgams, and Model Choice (Adam M. Finkel).

Response to Comments (Melissa Whitney and Louise Ryan).

5 Combining Risks from Several Tumors Using Markov Chain Monte Carlo (Leonid Kopylev, John Fox, and Chao Chen).

6 Uncertainty in Dose Response from the Perspective of Microbial Risk (P. F. M. Teunis).

7 Conclusions (David Bussard, Peter Preuss, and Paul White).

Author Index.

Subject Index.