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Synthetic Peptides as Antigens

ISBN: 978-0-470-51329-3
318 pages
April 2008
Synthetic Peptides as Antigens (0470513292) cover image


The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
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Table of Contents

Symposium on Synthetic Peptides as Antigens, held at the Ciba Foundation, London, 4–6 June 1985

The subject of this symposium was proposed by P. Dukor and D. G. Braun

Editors: Ruth Porter (Organizer) and Julie Whelan

G. L. Ada Introduction

J. H. Humphrey Regulation of in vivo immune responses: few principles and much ignorance


P. J. Lachmann, L. Strangeways, A. Vyakarnam and G. I. Evan Raising antibodies by coupling peptides to PPD and immunizing BCG-sensitized animals


H. J. Dyson, K. J. Cross, J. Ostresh, R. A. Houghten, I. A. Wilson, P. E. Wright and R. A. Lerner Selection by site-directed antibodies of small regions of peptides which are ordered in water


M. H. V. Van Regenmortel, D. Altschuh and A. Klug Influence of local structure on the location of antigenic determinants in tobacco mosaic virus protein


M. J. Crumpton The importance of conformation and of equilibria in the interaction of globular proteins and their fragments with antibodies


A. B. Edmundson and K. R. Ely Three-dimensional analyses of the binding of synthetic chemotactic and opioid peptides in the Mcg light chain dimer


H. M. Geysen, S. J. Rodda and T. J. Mason The delineation of peptides able to mimic assembled epitopes


V. Nussenzweig and R. S. Nussenzweig Experimental basis for the development of a synthetic vaccine against Plasmodium falciparum malaria sporozoites


R. F. Anders, P-T. Shi, D. B. Scanlon, S. J. Leach, R. L. Coppel, G. V. Brown, H-D. Stahl and D. J. Kemp Antigenic repeat structures in proteins of Plasmodium falciparum


M. Sela, R. Arnon and C. O. Jacob Synthetic peptides with antigenic specificity for bacterial toxins


V. C. Stevens Use of synthetic peptides as immunogens for developing a vaccine against human chorionic gonadotropin


D. R. Stanworth, D. S. Butt and G. Z. Hastings The use of synthetic peptides in the delineation of immunoglobulin antigenic epitopes and Fc effector functions


G. I. Evan, D.C. Hancock, T. Littlewood and C. D. Pauza Characterization of the human c-myc protein using antibodies prepared against synthetic peptides


S. S. Alkan and D. G. Braun Epitope mapping of human recombinant interferon alpha molecules by monoclonal antibodies


Final general discussion Reactivity of anti-peptide antibodies with the parent proteins

The proportion of monoclonal antibodies reactive to conformational or other linear sequences

High and low affinity antibodies and their roles

T-dependent and T-independent antigen presentation

G. L. Ada Chairman’s summing-up

Index of contributors

Subject index

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