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Transport and Trafficking in the Malaria-Infected Erythrocyte, No. 226

ISBN: 978-0-470-51574-7
304 pages
April 2008
Transport and Trafficking in the Malaria-Infected Erythrocyte, No. 226 (0470515740) cover image
There is an urgent need to uncover new therapies that will protect against malaria, as the parasite becomes increasingly resistant to available drugs and this book offers insights into three interrelated aspects of the malaria-infected erythrocyte:

* The transport of solutes into and out of the infected cell and the use of specific trafficking pathways in drug targeting

* The traffic of proteins produced by the intracellular parasite as an essential process for the biogenesis of transport systems.

* The relationship between the transport of drugs into the infected cell and the mode of drug action and drug resistance.
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Introduction: host-parasite interrelations in the genomic age

H. GINSBURG

Erythrocyte membrane transport

Z. I. CABANTCHIK

Chemical and physical in vitro alterations of the erythrocyte membrane: a model for its pathophysiological states?

B. DEUTICKE

The effects of transport perturbations on the homeostasis of red blood cells

V. LEW and A.R. HOCKADAY

Transport properties of the host cell membrane

K. KIRK, H.M. STAINES, R.E. MARTIN and K.J. SALIBA

Transport of phospholipid synthesis precursors and lipid trafficking into malaria-infected erythrocytes

H.J. VIAL, P. ELDIN, D. MARTIN, L. GANNOUN, M. CALAS and M.L. ANCELIN

A nutrient-permeable channel on the intraerythrocytic malaria parasite

S.A. DESAI

The permeability properties of the parasite cell membrane

H. GINSBURG

Macromolecular transport in malaria-infected erythrocytes

T. F. TARASCHI

Expression of parasite transporters in Xenopus oocytes

S. KRISHNA and C.J. WOODROW

Reconstitution of protein transport across the vacuolar membrane in Plasmodium falciparum-infected permeabilized erythrocytes

S. BAUMEISTER, A. BURGWEDEL, U.-G. MAIER and K. LINGELBACH

Export of parasite proteins to the erythrocyte cytoplasm: secretory machinery and signalling motifs

F.R. ALBANO, M. FOLEY and L. TILLEY

Transport and trafficking: Toxoplasma as a model for Plasmodium

D.S. ROOS, M.J. CRAWFORD, R.G.K. DONALD, L.M. FOHL, K.M. HAGER, J.C. KISSINGER, M.G. REYNOLDS, B. STREIPEN and W.J. SULLIVAN Jr

An alternative secretory pathway in Plasmodium: more questions than answers

M.F. WISER, D.J. GRAB, and H.N. LANNERS

The transport of the histidine-rich protein I from Plasmodium falciparum is insensitive to brefeldin A

D. MATTEI, L. BERRY, S. COUFFIN and O. RICHARD

Protein transport in the host cell cytoplasm and ATP-binding cassette proteins in Plasmodium falciparum-infected erythrocytes

Z. BOZDECH and E. SCHURR

Chloroquine uptake and activity is determined by binding to ferriprotoporphyrin IX in Plasmodium faciparum

P.G. BRAY, O. JANNEH and S.A. WARD

Chloroquine uptake, altered partiitioning and the basis of drug resistance: evidence for chloride dependent ionic regulation

J.A. MARTINEY, A.S. FERRER, A. CERAMI, S. DZEKUNOV and P. ROEPE

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"...an excellent reference work for those in the field..." (Cell Biology International, Vol.26, No. 4, 2002)
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