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Neuromuscular Disorders

Rabi Tawil (Editor), Shannon Venance (Editor)
ISBN: 978-0-470-65456-9
280 pages
October 2011, Wiley-Blackwell
Neuromuscular Disorders (0470654562) cover image
A practical framework for patients with problems that localize to the neuromuscular system

Our understanding of neuromuscular disease has advanced greatly in recent years. This has brought increased treatment options but also increased complexity. Diagnosis remains predominantly a clinical exercise. Early and accurate diagnosis coupled with modern medical management can increase the life quality and life expectancy of patients with neuromuscular disease.

Neuromuscular Disorders presents a practical framework for managing patients with neuromuscular dysfunction. It covers the spectrum of disease from the common to the rare with handy tips and tricks to improve clinical practice. Beginning with a guide to clinical diagnosis it includes:

  • Myopathies
  • Disorders of the neuromuscular junction
  • Disorders of peripheral nerve
  • Disorders of motor neurons

Clinical in approach, practical in execution, Neuromuscular Disorders will help you diagnose and manage your patients more effectively.

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Contributor List viii

Acknowledgment x

Series Foreword xi

Preface xii

1 Neuromuscular Diseases: Approach to Clinical Diagnosis 1
Shannon Venance and Rabi Tawil

part i myopathies

2 Approach to Diseases of Muscle 9
Matthew P. Wicklund

3 Inflammatory Myopathies 15
Steven A. Greenberg

4 Toxic Myopathies 22
Steven K. Baker

5 Metabolic Myopathies 30
Ingrid Tein

6 Mitochondrial Myopathies 42
Michio Hirano, Valentina Emmanuele, and Catarina M. Quinzii

7 Dystrophinopathies 51
Shannon L. Venance

8 Limb–Girdle Dystrophies 57
Michela Guglieri and Kate Bushby

9 Facioscapulohumeral Dystrophy 74
Constantine Farmakidis and Rabi Tawil

10 Myotonic Dystrophies 80
Nicholas Johnson and Chad R. Heatwole

11 Oculopharyngeal Muscular Dystrophy 87
Annie Dionne and Jean-Pierre Bouchard

12 Distal Myopathies 91
Bjarne Udd

13 Muscle Channelopathies 96
James Burge and Michael G. Hanna

14 Congenital Myopathies 103
Nigel Clarke and Kathryn North

part ii disorders of the neuromuscular junction

15 Approach to Diseases of the Neuromuscular Junction 113
Donald B. Sanders

16 Myasthenia Gravis 118
Michael K. Hehir and Emma Ciafaloni

17 Botulism 126
Nikhil Balakrishnan and Matthew N. Meriggioli

18 Lambert–Eaton Myasthenic Syndrome 134
Michael W. Nicolle

19 Congenital Myasthenic Syndromes 142
Andrew G. Engel

part iii disorders of peripheral nerve

20 Approach to Diagnosis of Peripheral Nerve Disease 153
James C. Cleland and Eric L. Logigian

21 Hereditary Motor Sensory Neuropathies (Charcot–Marie–Tooth Disease) 162
Araya Puwanant and David N. Herrmann

22 Diabetic Neuropathies 170
Douglas W. Zochodne

23 Toxic and Metabolic Neuropathies 177
Kurt Kimpinski

24 Acute Infl ammatory Demyelinating Neuropathies and Variants 183
Mazen M. Dimachkie and Richard J. Barohn

25 Chronic Immune-mediated Demyelinating Polyneuropathies 190
Agnes Jani-Acsadi and Richard A. Lewis

26 Vasculitic Neuropathies 198
W. David Arnold and John T. Kissel

27 Paraneoplastic Neuropathies 204
Pariwat Thaisetthawatkul

28 Brachial and Lumbosacral Plexopathies 210
Kristine M. Chapman and Amanda Sherwin

part iv disorders of motor neurons

29 Approach to Diseases of the Motor Neurons 223
Christen Shoesmith

30 Spinal Muscular Atrophy 229
Jacqueline Montes and Petra Kaufmann

31 Amyotrophic Lateral Sclerosis 236
Amy Chen and Hiroshi Mitsumoto

32 Neuromuscular Disorders in the Intensive Care Unit 243
Maxwell S. Damian and David Hilton-Jones

Index 249

The colour plate section can be found facing page 228.

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Rabi N. Tawil, MD, University of Rochester Medical Center, Rochester, New York, USA

Shannon Venance, MD, PhD, FRCPCP, The University of Western Ontario, London, Ontario, Canada

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“This excellent book should be made available to students rotating through neurology, and should be owned by every neurology resident and most neurologists.”  (Canadian Journal of Neurological Sciences, 1 September 2012)
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