Metals in Medicine
Following this introduction, chapters focus on individual metallo-drugs and agents for treating and detecting disease, their synthesis, structure and general properties, known mechanism of action and important physical and chemical principles that apply. Topics covered include cisplatin; platinum anticancer drugs; ruthenium, titanium, and gallium for treating cancer; gold compounds for treating arthritis, cancer, and other diseases; vanadium, copper, and zinc in medicine; metal complexes for diagnosing disease; and metals in nanomedicine.
Throughout the book, “Feature Boxes” expand on features of drugs that are not directly related to studying metals in medicine, for example discovery, medical use, specialist assays, and metals in biology. At the end of the chapters there are specifically designed problems/exercises that apply basic kinetic, thermodynamic and chemical principles to practical problem solving in metals in medicine.
Metals in Medicine distils the essence of this important topic for undergraduate and graduate students in chemistry, biochemistry, biology and the related areas of biophysics, pharmacology, and bioengineering, and for researchers in other fields interested in getting a general insight into metals in medicine.
1 Inorganic Chemistry Basics.
1.1 Crystal field theory.
1.2 Molecular orbital theory.
1.3 Absorption spectra of metal complexes.
1.4 Magnetic properties of metal complexes.
1.5 Reactions of metal complexes.
2 Metallo-Drugs and Their Action.
2.2 Proteins as targets for metallo-drugs.
2.3 DNA as a target for metallo-drugs.
2.4 Reaction of metal complexes in the biological milieu.
2.5 Evaluating the pharmacological effects of agents.
2.6 From discovery to the marketplace.
3.1 Physical and chemical properties of cisplatin.
3.2 Formulation, administration and pharmacokinetics.
3.3 Reaction of cisplatin in biological media.
3.4 Uptake, cytotoxicity and resistance.
3.5 Interaction of cisplatin with cellular targets.
4 Platinum Anticancer Drugs.
4.3 New platinum agents.
5 Ruthenium, Titanium and Gallium for Treating Cancer.
5.1 Ruthenium compounds for treating cancer.
5.2 Titanium compounds for treating cancer.
5.3 Gallium for treating cancer.
6 Gold Compounds for Treating Arthritis, Cancer and Other Diseases.
6.1 Chemistry of gold in biological media.
6.2 Gold compounds for treating arthritis.
6.3 Gold complexes for treating cancer.
6.4 Gold complexes for treating AIDS and other diseases.
7 Vanadium, Copper and Zinc in Medicine.
7.1 Vanadium for treating diabetes.
7.2 Role of copper and other metal ions in Alzheimer’s disease.
7.3 Copper in Wilson’s and Menkes diseases.
7.4 Zinc–bicyclam: a chemokine receptor antagonist.
8 Metal Complexes for Diagnosing Disease.
8.1 Technetium in diagnostic nuclear medicine.
8.2 Metal compounds as contrast agents for MRI.
8.3 Radionuclides for palliative care and cancer treatment.
9.1 Nanoscience for treating disease.
9.2 Nanomedicine in diagnosing disease.
9.3 Potential health risks of nanoparticles.
- covers all aspects of medicinal inorganic chemistry in a single text. Usually this important topic is fragmented across several chapters of larger bioinorganic chemistry books
- extensive references and bibliography to point the way to further information
- topics are organized in a way that appeals to those new to the subject, with an introduction to important underlying themes and concepts followed by a focus on the application of individual metallo-drugs
- “Feature Boxes” appear thoughout the text. These expand important concepts in metals in medicine, providing sufficient information to see “how things work” with additional information being found in the sources at the end of the feature box and the extensive list of references at the end of the chapter.
- Following each chapter are specifically designed questions, with solutions, that allow the student to apply the laws of thermodynamics and the principles of equilibrium and kinetics to problem solving in the topic being addressed.