Editors.

Section 1  History and Heritage.

Introduction by P Lefèbvre. 

1. Galegine and antidiabetic plants.  
2. Discovery of metformin.      
3. Introduction of metformin into clinical practice: the French innovation.
4. Metformin: a chemical perspective.      
5. Pharmaceutical development of metformin.

Section 2  Efficacy.

Introduction by R A DeFronzo.

6. Defining the clinical utility of metformin: reflections from Scotland.
7. Metformin in combination.    
8. Metformin in children and adolescents with type 2 diabetes.         
9. Dose-related antihyperglycaemic efficacy of metformin.      
10. Understanding the glucose-lowering actions of metformin.      
11. Focus on metformin and body weight. 
12. Insights into the effects of metformin on the lipid profile.

Section 3  Cardiovascular Benefits.

Introduction by R Holman.

13. Metformin and cardiovascular protection: lessons from the UK Prospective Diabetes Study.
14. Survival benefits of metformin in high-risk populations.      
15. Mechanisms of vascular protection with metformin.

Section 4  Health Outcomes.

Introduction by C-Y Pan.

16. Defining the health economic benefits of metformin.      
17. Impact of metformin on quality of life.

Section 5   Safety.

Introduction by N Hotta.

18. Tolerability of metformin.      
19. Measures to improve the gastrointestinal tolerability of metformin.      
20. Defining the risk of lactic acidosis.           
21. Defining patient populations not indicated for metformin.

Section 6  Guidelines.

Introduction by D J Chisholm.

22. The role of metformin in setting treatment standards within
    management guidelines.        

Section 7  Future Indications.

Introduction by J J Gagliardino.

23. The potential of metformin for diabetes prevention.       
24. The role of metformin in polycystic ovary syndrome and infertility.         
25. Potential of metformin in the management of insulin-resistant states.
26. The potential of metformin for the treatment of neoplastic disease.
27. Future role of metformin in healthcare therapy.

Section 8  The metformin 50-year roll of honour.

Index.