Human Drug Metabolism: An Introduction, 2nd Edition

·         Completely revised and updated throughout with new chapter on drug metabolism and disease states with the Clinical Relevance Section revised to include current clinical status of CYP2D6/CYP2C9 genotyping (cost problems, lack of physician knowledge, uncertainty as to how the information can be used) as well as cost/benefit.

·         More emphasis on genotyping value for warfarin and a more balanced clinical appraisal of value of genotyping for specific drugs (e.g. perhexiline, nortryptyline.

• New material includes; more examples of induction with newer anticonvulsants, OTC herbal remedies with expanded coverage of the  impact on protease inhibitors
• New section on Butyrylcholinesterase and the neuromuscular blockers (mivacurium etc) and new material on dihydropyrimidine dehydrogenase/5-FU and recent toxicity studies.