The Pulmonary Endothelium: Function in Health and Disease

List of Contributors xi

Introduction
Sharon Rounds and Norbert Voelkel xvii

SECTION I: NORMAL PULMONARY ENDOTHELIUM. STRUCTURE, FUNCTION, CELL BIOLOGY 1

1: Development of the Pulmonary Endothelium in Development of the Pulmonary Circulation: Vasculogenesis and Angiogenesis
Margaret A. Schwarz and Ondine B. Cleaver 3

2: Anatomy of the Pulmonary Endothelium
Radu V. Stan 25

3: Cadherins and Connexins in Pulmonary Endothelial Function
Kaushik Parthasarathi and Sadiqa K. Quadri 33

4: Pulmonary Endothelial Cell Interactions with the Extracellular Matrix
Katie L. Grinnell and Elizabeth O. Harrington 51

5: Pulmonary Endothelial Cell Calcium Signaling and Regulation of Lung Vascular Barrier Function
Nebojsa Knezevic, Mohammad Tauseef and Dolly Mehta 73

6: Pulmonary Endothelium and Nitric Oxide
Yunchao Su and Edward R. Block 89

7: Pulmonary Endothelial Cell Surface Metabolic Functions
Usamah S. Kayyali and Barry L. Fanburg 105

8: Cell Biology of Lung Endothelial Permeability
Guochang Hu and Richard D. Minshall 113

9: Lung Endothelial Phenotypes: Insights Derived from the Systematic Study of Calcium Channels
Donna L. Cioffi, Songwei Wu and Troy Stevens 129

10: Pulmonary Endothelial Interactions with Leukocytes and Platelets
Rosana Souza Rodrigues and Guy A. Zimmerman 143

11: Mesenchymal–Endothelial Interactions in the Control of Angiogenic, Inflammatory, and Fibrotic Responses in the Pulmonary Circulation
Kurt R. Stenmark, Evgenia V. Gerasimovskaya, Neil Davie and Maria Frid 167

12: Pulmonary Endothelium and Vasomotor Control
Nikki L. Jernigan, Benjimen R. Walker and Thomas C. Resta 185

13: Pulmonary Endothelial Progenitor Cells
Bernard Thebaud and Mervin C. Yoder 203

14: Bronchial Vasculature: The Other Pulmonary Circulation
Elizabeth Wagner 217

15: Mapping Protein Expression on Pulmonary Vascular Endothelium
Kerri A. Massey and Jan E. Schnitzer 229

SECTION II: MECHANISMS AND CONSEQUENCES OF PULMONARY ENDOTHELIAL CELL INJURY 241

16: Pulmonary Endothelial Cell Death: Implications for Lung Disease Pathogenesis
Qing Lu and Sharon Rounds 243

17: Oxidant-Mediated Signaling and Injury in Pulmonary Endothelium
Kenneth E. Chapman, Shampa Chatterjee and Aron B. Fisher 261

18: Hypoxia and the Pulmonary Endothelium
Matthew Jankowich, Gaurav Choudhary and Sharon Rounds 287

19: Viral Infection and Pulmonary Endothelial Cells
Norbert F. Voelkel 303

20: Effects of Pressure and Flow on the Pulmonary Endothelium
Wolfgang M. Kuebler 309

21: Therapeutic Strategies to Limit Lung Endothelial Cell Permeability
Rachel K. Wolfson, Gabriel Lang, Jeff Jacobson and Joe G. N. Garcia 337

22: Targeted Delivery of Biotherapeutics to the Pulmonary Endothelium
Vladimir R. Muzykantov 355

SECTION III:PULMONARY ENDOTHELIUM IN DISEASE 379

23: Endothelial Regulation of the Pulmonary Circulation in the Fetus and Newborn
Yuansheng Gao and J. Usha Raj 381

24: Genetic Insights into Endothelial Barrier Regulation in the Acutely Inflamed Lung
Sumegha Mitra, Daniel Turner Lloveras, Shwu-Fan Ma and Joe G. N. Garcia 399

25: Interactions of Pulmonary Endothelial Cells with Immune Cells and Platelets: Implications for Disease Pathogenesis
Mark R. Nicolls, Rasa Tamosiuniene, Ashok N. Babu and Norbert F. Voelkel 417

26: Role of the Endothelium in Emphysema: Emphysema – A Lung Microvascular Disease
Norbert F. Voelkel and Ramesh Natarajan 437

27: Pulmonary Endothelium and Pulmonary Hypertension
Rubin M. Tuder and Serpil C. Erzurum 449

28: Collagen Vascular Diseases and Pulmonary Endothelium
Pradeep R. Rai and Carlyne D. Cool 461

29: Pulmonary Endothelium in Thromboembolism
Irene M. Lang 471

30: Pulmonary Endothelium and Malignancies
Abu-Bakr Al-Mehdi 485

Epilogue
Norbert F. Voelkel 491

Index 495