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The Pulmonary Endothelium: Function in Health and Disease

Norbert Voelkel (Editor), Sharon Rounds (Editor)
ISBN: 978-0-470-74750-6
532 pages
August 2009
The Pulmonary Endothelium: Function in Health and Disease (0470747501) cover image
The Pulmonary Endothelium is a uniquely comprehensive compendium of our current knowledge of the pulmonary endothelium and is the first book dedicated specifically to the subject, offering insights into current and future approaches to management. The text provides the clinician with the most up-to-date information on one of the core physiological processes in airway disease and is an ideal point of reference for both postgraduates and professionals – specialist physicians in pulmonology and allergy and workers in biomedical and pharmaceutical research.
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List of Contributors xi

Introduction
Sharon Rounds and Norbert Voelkel xvii

SECTION I: NORMAL PULMONARY ENDOTHELIUM. STRUCTURE, FUNCTION, CELL BIOLOGY 1

1: Development of the Pulmonary Endothelium in Development of the Pulmonary Circulation: Vasculogenesis and Angiogenesis
Margaret A. Schwarz and Ondine B. Cleaver 3

2: Anatomy of the Pulmonary Endothelium
Radu V. Stan 25

3: Cadherins and Connexins in Pulmonary Endothelial Function
Kaushik Parthasarathi and Sadiqa K. Quadri 33

4: Pulmonary Endothelial Cell Interactions with the Extracellular Matrix
Katie L. Grinnell and Elizabeth O. Harrington 51

5: Pulmonary Endothelial Cell Calcium Signaling and Regulation of Lung Vascular Barrier Function
Nebojsa Knezevic, Mohammad Tauseef and Dolly Mehta 73

6: Pulmonary Endothelium and Nitric Oxide
Yunchao Su and Edward R. Block 89

7: Pulmonary Endothelial Cell Surface Metabolic Functions
Usamah S. Kayyali and Barry L. Fanburg 105

8: Cell Biology of Lung Endothelial Permeability
Guochang Hu and Richard D. Minshall 113

9: Lung Endothelial Phenotypes: Insights Derived from the Systematic Study of Calcium Channels
Donna L. Cioffi, Songwei Wu and Troy Stevens 129

10: Pulmonary Endothelial Interactions with Leukocytes and Platelets
Rosana Souza Rodrigues and Guy A. Zimmerman 143

11: Mesenchymal–Endothelial Interactions in the Control of Angiogenic, Inflammatory, and Fibrotic Responses in the Pulmonary Circulation
Kurt R. Stenmark, Evgenia V. Gerasimovskaya, Neil Davie and Maria Frid 167

12: Pulmonary Endothelium and Vasomotor Control
Nikki L. Jernigan, Benjimen R. Walker and Thomas C. Resta 185

13: Pulmonary Endothelial Progenitor Cells
Bernard Thebaud and Mervin C. Yoder 203

14: Bronchial Vasculature: The Other Pulmonary Circulation
Elizabeth Wagner 217

15: Mapping Protein Expression on Pulmonary Vascular Endothelium
Kerri A. Massey and Jan E. Schnitzer 229

SECTION II: MECHANISMS AND CONSEQUENCES OF PULMONARY ENDOTHELIAL CELL INJURY 241

16: Pulmonary Endothelial Cell Death: Implications for Lung Disease Pathogenesis
Qing Lu and Sharon Rounds 243

17: Oxidant-Mediated Signaling and Injury in Pulmonary Endothelium
Kenneth E. Chapman, Shampa Chatterjee and Aron B. Fisher 261

18: Hypoxia and the Pulmonary Endothelium
Matthew Jankowich, Gaurav Choudhary and Sharon Rounds 287

19: Viral Infection and Pulmonary Endothelial Cells
Norbert F. Voelkel 303

20: Effects of Pressure and Flow on the Pulmonary Endothelium
Wolfgang M. Kuebler 309

21: Therapeutic Strategies to Limit Lung Endothelial Cell Permeability
Rachel K. Wolfson, Gabriel Lang, Jeff Jacobson and Joe G. N. Garcia 337

22: Targeted Delivery of Biotherapeutics to the Pulmonary Endothelium
Vladimir R. Muzykantov 355

SECTION III:PULMONARY ENDOTHELIUM IN DISEASE 379

23: Endothelial Regulation of the Pulmonary Circulation in the Fetus and Newborn
Yuansheng Gao and J. Usha Raj 381

24: Genetic Insights into Endothelial Barrier Regulation in the Acutely Inflamed Lung
Sumegha Mitra, Daniel Turner Lloveras, Shwu-Fan Ma and Joe G. N. Garcia 399

25: Interactions of Pulmonary Endothelial Cells with Immune Cells and Platelets: Implications for Disease Pathogenesis
Mark R. Nicolls, Rasa Tamosiuniene, Ashok N. Babu and Norbert F. Voelkel 417

26: Role of the Endothelium in Emphysema: Emphysema – A Lung Microvascular Disease
Norbert F. Voelkel and Ramesh Natarajan 437

27: Pulmonary Endothelium and Pulmonary Hypertension
Rubin M. Tuder and Serpil C. Erzurum 449

28: Collagen Vascular Diseases and Pulmonary Endothelium
Pradeep R. Rai and Carlyne D. Cool 461

29: Pulmonary Endothelium in Thromboembolism
Irene M. Lang 471

30: Pulmonary Endothelium and Malignancies
Abu-Bakr Al-Mehdi 485

Epilogue
Norbert F. Voelkel 491

Index 495

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