Multidimensional NMR Methods for the Solution State
The content of this volume has been added to eMagRes (formerly Encyclopedia of Magnetic Resonance) - the ultimate online resource for NMR and MRI.
The literature of multidimensional NMR began with the publication of three papers in 1975, then nine in 1976 and fifteen in 1977, and now contains many tens of thousands of papers. Any attempt to survey the field must therefore necessarily be very selective, not to say partial. In assembling this handbook, the Editors have sought to provide both the new researcher and the established scientist with a solid foundation for the understanding of multidimensional NMR, a representative if inevitably limited survey of its applications, an authoritative account of classic techniques such as COSY, NOESY and TOSCY, and an account of the latest progress in the development of multidimensional techniques.
This handbook is structured in four parts. The first opens with an historical introduction to, and a brief account of, the practicalities and applications of multidimensional NMR methods, followed by a definitive survey of their conceptual basis and a series of articles setting out the generic principles of methods for acquiring and processing multidimensional NMR data. In the second part, the main families of multidimensional techniques, arranged in approximate order of increasing complexity, are described in detail, from simple J-resolved spectroscopy through to the powerful heteronuclear 3D and 4D methods that now dominate the study of structural biology in solution. The third part offers and illustrative selection from the very wide range of applications of multidimensional NMR methods, including some of the most recent developments in protein NMR. Finally, the fourth part introduces the idea of multidimensional spectra containing non-frequency dimensions, in which properties such as diffusion and relaxation are correlated.
About EMR Handbooks / eMagRes Handbooks
The Encyclopedia of Magnetic Resonance (up to 2012) and eMagRes (from 2013 onward) publish a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of EMR Handbooks / eMagRes Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of articles from eMagRes. In consultation with the eMagRes Editorial Board, the EMR Handbooks / eMagRes Handbooks are coherently planned in advance by specially-selected Editors, and new articles are written (together with updates of some already existing articles) to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry.
Part A: Principles.
1 Multidimensional NMR: an Introduction (Gareth A. Morris, James W. Emsley).
2 Multidimensional Spectroscopy: Concepts (Richard R. Ernst).
3 Ultrafast Multidimensional NMR: Principles and Practice of Single-Scan Methods (Maayan Gal, Lucio Frydman).
4 Fast Multidimensional NMR by Hadamard Spectroscopy (Ray Freeman, Eriks Kupce).
5 Multidimensional NMR by Projection-Reconstruction (Ray Freeman, Eriks Kupce).
6 Rapid Multidimensional NMR: Decomposition Methods and their Applications (Martin Billeter, Doroteya K. Staykova).
7 Multidimensional Correlation Spectroscopy by Covariance NMR (David A. Snyder, Rafael Bruschweiler).
8 Maximum Entropy Methods in Multidimensional NMR (Jeffrey C. Hoch, Mehdi Mobli).
9 Filter Diagonalization Methods for Time-Domain Signals (A. J. Shaka, Vladimir A. Mandelshtam).
10 Fourier Transform and Linear Prediction Methods (Jens J. Led, Henrik Gesmar).
Part B: Techniques.
11 Two-Dimensional J-Resolved Spectroscopy (Gareth A. Morris).
12 COSY (David M. Doddrell).
13 COSY: Quantitative Analysis (Alex D. Bain).
14 E.COSY: Determination of Coupling Constants (Harald Schwalbe, P. Schmidt, Christian Griesinger).
15 Relayed Coherence Transfer Experiments (Philip H. Bolton).
16 TOCSY (Timothy D. W. Claridge).
17 Multiple Quantum Spectroscopy of Liquid Samples (Timothy J. Norwood).
18 NOESY (Michael P. Williamson).
19 ROESY (Ad Bax, Stephan Grzesiek).
20 TOCSY in ROESY and ROESY in TOCSY (J. Schleucher, J. Quant, S. J. Glaser, Christian Griesinger).
21 2D Methods of Monitoring Exchange (Keith G. Orrell).
22 Heteronuclear Shift Correlation Spectroscopy (Thomas T. Nakashima, R. E. D. McClung).
23 2D Methods for the Measurement of Long-Range Proton–Carbon Coupling Constants (Teodor Parella).
24 Homonuclear 3D NMR of Biomolecules Rolf Boelens, Robert Kaptein).
25 3D HMQC-NOESY, NOESY-HMQC, and NOESY-HSQC (Ranjith Muhandiram, Lewis E. Kay).
26 3D and 4D Heteronuclear Magnetic Resonance (G. Marius Clore, Angela M. Gronenborn).
Part C: Applications.
27 2D Carbon–Heteroelement Correlation (Stefan Berger).
28 Multidimensional NMR in Organotin Chemistry and Catalysis (Monique Biesemans, Rudolph Willem).
29 2D NMR of Molecules Oriented in Liquid Crystalline Phases (Anil Kumar).
30 2D NMR of Molecules Oriented in Liquid Crystals—Recent Developments (Anil Kumar, N. Suryaprakash).
31 Local Field Experiments in Liquid Crystals (Stefano Caldarelli).
32 Multiple Quantum Spectroscopy in Liquid Crystalline Solvents (Leslie D. Field).
33 Biological Macromolecules: Structure Determination in Solution (Kurt W¨uthrich).
34 Structures of Larger Proteins, Protein–Ligand, and Protein–DNA Complexes by Multidimensional Heteronuclear NMR (G. Marius Clore, Angela M. Gronenborn).
35 Rapid Multidimensional NMR: Fast Pulsing Techniques and their Applications to Proteins (Bernhard Brutscher, Paul Schanda).
Part D: Related Techniques.
36 Diffusion-Ordered Spectroscopy (Gareth A. Morris).
37 2D Relaxometry (Brian P. Hills).