Biopharmaceuticals: Biochemistry and Biotechnology, 2nd Edition
August 2003, Wiley-Blackwell
This superbly written review of the important areas of investigation in the field, covers drug production, plus the biochemical and molecular mechanisms of action together with the biotechnology of major biopharmaceutical types on the market or currently under development. There is also additional material reflecting both the technical advances in the area and detailed information on key topics such as the influence of genomics on drug discovery.
Chapter 1. Pharmaceuticals, biologies and biopharmaceuticals.
Chapter 2. The drug development process.
Chapter 3. The drug manufacturing process.
Chapter 4. The cytokines—the interferon family.
Chapter 5. Cytokines: interleukins and tumour necrosis factor.
Chapter 6. Haemopoietic growth factors.
Chapter 7. Growth factors.
Chapter 8. Hormones of therapeutic interest.
Chapter 9. Blood products and therapeutic enzymes.
Chapter 10. Antibodies, vaccines and adjuvants.
Chapter 11. Nucleic acid therapeutics.
Appendix 1. Biopharmaceuticals thus far approved in the USA or European Union.
Appendix 2. Some Internet addresses relevant to the biopharmaceutical sector.
Appendix 3. Two selected monographs reproduced from the European Pharmacopoeia with permission from the European Commission: I. Products of recombinant DNA Technology; II. Interferon a -2 concentrated solution.
Appendix 4. Manufacture of biological medicinal products for human use. (Annex 2 from The Rules Governing Medicinal Products in the European Community, Vol. 4, Good Manufacturing Practices for Medicinal Products).
- One of the first key textbooks on the market to comprehensively outline the science of the biopharmaceutical industry.
- Provides an extensive, up-to-date overview of the science and medical applications of biopharmaceutical products.
- Includes additional relevant material to reflect the recent technological advances in the subject and also includes a new section on the impact of genomics on drug discovery
"...well written… (and) copiously illustrated..." (Chemistry & Industry, 17th January 2005)
“This book should be recommended reading for all under-graduate course in pharmacy and the pharmaceutical sciences …”. (Cell Biochemistry & Function, March-April 2005)