Neuroendocrinology: An Integrated Approach
This book provides a much-needed introduction to neuroendocrinology from a zoological and evolutionary perspective. It covers the evolution, development and description of the neuroendocrine system throughout the animal kingdom.
Specific topics covered include:
- The Evolution of early neuroendocrine systems in primitive animals
- Structural characterisation, molecular biology and biochemistry of neuroendocrine agents
- A profiles section on unusual aspects of neuroendocrine physiology written by leaders in the field
- A unique section on the actions of environmental chemicals effect neuroendocrine systems in various species
1. History of Neuroendocrinology and Neurohormones Introduction.
Early history of physiology.
Renaissance and the growth of western science.
The 19th-century physiology and medicine.
Neurosecretion and the hypothalamus–pituitary regulation.
2. Origin of Life and the First Signalling Molecules.
Theories of the evolution of the first cells.
The first cells.
The first true signalling hormones.
3. Rise of Metazoans and the Elaboration of Signalling Systems.
Colonialism and multicellularity.
The elaboration of hormone pathways
Nervous systems and rudimentary neuroendocrine systems.
Increase in genetic complexity and the rise of triploblastic organisms.
4. Elaboration of Neuroendocrine Systems.
Elaboration of nervous system and development of organismal complexity.
Nervous and neuroendocrine systems in phylogenetically younger invertebrates.
Nervous and neuroendocrine systems in the deuterostomes.
Peripheral and autonomic nervous systems.
Cerebrospinal fluid and the choroid plexus.
Neurohaemal and circumventricular organs: Neurovascular interfaces.
Hypothalamus–pituitary gland complex.
5. Neurohormones and Receptors: Structure, Function and Co-evolution.
Orthology and paralogy.
Structural description of non-peptide ligands.
Peptide and polypeptide signalling molecules.
Structure and classes of receptors.
6. Osmoregulation, Metabolism and Energy Production.
Role of prolactin.
Feeding and appetite regulation.
Neural circuitry associated with feeding.
7. Growth and Development.
Growth and the growth hormone, prolactin, somatolactin superfamily.
Metamorphosis and development.
Mechanisms of ageing.
8. Biological Rythms.
Origin of biological clocks.
Clock circuitry in vertebrates.
The role of melatonin.
9. Stress, Arousal and Homeostatic Challenge.
Physiology and behaviour associated with stress Components of the stress-response system.s
Corticotropin-releasing factor superfamily of peptides.
Proopiomelanocortin and adrenocorticotrophic hormone.
Integration of HPA/I components with other systems.
Complementary neuroendocrine circuits associated with stress.
Selection of sexual reproduction.
Regulation of reproduction.
Gonadotrophins and their regulation.
Neuroendocrine regulation of the HPG axis.
Pregnancy, parturition and lactation.
Reproduction and stress.
11. Behaviour, Learning and Memory.
Basic behavioural circuits.
Motivation: Reward and fear.
Stress and the modulation of learning and behaviour.
Hormonal facilitation of behaviour.
Galanin modulation of neurological circuits.
An integrated approach to behavioural modulation.
Neurodegeneration and trauma.
12. Pheromones and Chemo-attractants.
Evolution of pheromones.
Classification of pheromones.
Pheromones in invertebrates.
Pheromones in vertebrates.
Physiological actions of vertebrate pheromones.
Pheromones in mammals.
13. Xenobiotics and Hormone Mimics.
Types of xenobiotics.
Vertebrate toxins and defences.
Toxins and xenobiotics in invertebrates.
Toxins and hormone mimics in plants.
Hormone mimics from anthropogenic sources.
- Emphasis on the evolution of neuroendocrine systems in the animal kingdom
- Similarities and differences in neuroendocrine physiology between vertebrates and invertebrates
An integrated genes-to-environment approach
A profiles section on unusual aspects of neuroendocrine physiology written by leaders in the field
A unique section on the actions of environmental chemicals effect neuroendocrine systems in various species
"…provides important context for the development of neuroendocrinology." (Doody's Health Services)
"A clearly written introduction to neuroendocrinology from a zoological and evolutionary perspective." (Pediatric Endocrinology Reviews (PER), May 2006)
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