Integrative biological modelling in silico (A. McCulloch and G. Huber).

Advances in computing, and their impact on scientific computing (M. Giles).

From physics to phenomenology: Levels of description and levels of selection (D. Krakauer).

Making sense of complex phenomena in biology (P. Maini).

On ontologies for biologists: the Gene Ontology—untangling the web (M. Ashburner and S. Lewis).

General discussion I: Model validation.

The KEGG database (M. Kanehisa).

Shanka Subramaniam and the Bioinformatics Core Laboratory Bioinformatics of cellular signalling.

General discussion II: Standards of communication.

Semantics and intercommunicability. 

Imaging-based integrative models of the heart: closing the loop between experiment and simulation (R. Winslow, et al.).

General discussion III: Modelling Ca²⁺ signalling.

The Virtual Cell project (L. Loew).

Modelling the bacterial chemotaxis receptor complex (T. Shimizu and D. Bray).

The heart cell in silico: successes, failures and prospects (D. Noble).

General discussion IV.

The IUPS Physiome Project (P. Hunter, et al.).

Using in silico biology to facilitate drug development (J. Levin, et al).

Final discussion: Is there a theoretical biology?

Index of contributors.

Subject index.