CONTRIBUTORS xv

PART I SOURCES 1

Chapter 1 Introduction 3
Stuart B. Levy

Chapter 2 Path to Resistance 7
Vivian Miao, Dorothy Davies, and Julian Davies

Chapter 3 Antibiotic Resistome: A Framework Linking the Clinic and the Environment 15
Gerard D. Wright

Chapter 4 Ecological and Clinical Consequences of Antibiotic Subsistence by Environmental Microbes 29
Gautam Dantas and Morten O. A. Sommer

Chapter 5 Importance of Adaptive and Stepwise Changes in the Rise and Spread of Antimicrobial Resistance 43
Lucia Fernandez, Elena B. M. Breidenstein, and Robert E. W. Hancock

Chapter 6 Environmental Reservoirs of Resistance Genes in Antibiotic-Producing Bacteria and Their Possible Impact on the Evolution of Antibiotic Resistance 73
Paris Laskaris, William H. Gaze and Elizabeth M. H. Wellington

Chapter 7 Mechanisms of Bacterial Antibiotic Resistance and Lessons Learned from Environmental Tetracycline-Resistant Bacteria 93
Marilyn C. Roberts

Chapter 8 Environmental Antibiotic Resistome: New Insights from Culture-Independent Approaches 123
Isabel S. Henriques, Artur Alves, Maria Jose´ Saavedra, Mark H. M. M. Montforts, and Anto´nio Correia

PART II FATE 149

Chapter 9 Environmental Pollution by Antibiotic Resistance Genes 151
Jose Luis Martinez and Jorge Olivares

Chapter 10 Quantifying Anthropogenic Impacts on Environmental Reservoirs of Antibiotic Resistance 173
Amy Pruden and Mazdak Arabi

Chapter 11 Antibiotic Resistance in Swine-Manure-Impacted Environments 203
Joanne Chee-Sanford, Scott Maxwell, Kristy Tsau, Kelly Merrick, and Rustam Aminov

Chapter 12 Antimicrobial-Resistant Indicator Bacteria in Manure and the Tracking of Indicator Resistance Genes 225
Christina S. Ho¨lzel and Karin Schwaiger

Chapter 13 Municipal Wastewater as a Reservoir of Antibiotic Resistance 241
Timothy Lapara and Tucker Burch

Chapter 14 Strategies to Assess and Minimize the Biological Risk of Antibiotic Resistance in the Environment 251
Thomas Schwartz

Chapter 15 Antibiotic Resistance in Animals—The Australian Perspective 265
Olasumbo Ndi and Mary Barton

PART III ANTIMICROBIAL SUBSTANCES AND RESISTANCE 291

Chapter 16 Detection and Occurrence of Antibiotics and Their Metabolites in Pig Manure in Bavaria (Germany) 293
Katrin Harms and Johann Bauer

Chapter 17 Fate and Transport of Antibiotics in Soil Systems 309
Alistair B. A. Boxall

Chapter 18 Antibiotics in the Aquatic Environment 325
Klaus Ku¨mmerer

Chapter 19 Residues of Veterinary Drugs in Wild Fish 337
Thomas Heberer

Chapter 20 Role of Quaternary Ammonium Compounds on Antimicrobial Resistance in the Environment 349
Ulas Tezel and Spyros G. Pavlostathis

PART IV EFFECTS AND RISKS 389

Chapter 21 Human Health Importance of use of Antimicrobials in Animals and Its Selection of Antimicrobial Resistance 391
Scott A. McEwen

Chapter 22 Antimicrobial Resistance Associated with Salmonid Farming 423
Claudio D. Miranda

Chapter 23 Effect of Veterinary Medicines Introduced via Manure into Soil on the Abundance and Diversity of Antibiotic Resistance Genes on Their Transferability 453
Holger Heuer, Christoph Kopmann, Ute Zimmerling, Ellen Kro¨gerrecklenfort, Kristina Kleineidamm, Michael Schloter, Eva M. Top and Kornelia Smalla

Chapter 24 Tracking Antibiotics and Antibiotic Resistance Genes through the Composting Process and Field Distribution of Poultry Waste: Lessons Learned 465
Patricia L. Keen and Nancy De With

Chapter 25 Environmental Microbial Communities Living Under Very High Antibiotic Selection Pressure 483
Anders Janzon, Erik Kristiansson, and D. G. Joakim Larsson

Chapter 26 Antibiotic Use During an Influenza Pandemic: Downstream Ecological Effects and Antibiotic Resistance 503
Andrew C. Singer and Heike Schmitt

Chapter 27 Use of Veterinary Antibacterial Agents in Europe and the United States 539
Ingeborg M. van Geijlswijk, Nico Bondt, Linda F. Puister-Jansen, and Dik J. Mevius

Chapter 28 Regulatory Research on Antimicrobial Resistance in the Environment 549
Emily A. McVey and Mark H. M. M. Montforts

INDEX 569