Nutrition in Epigenetics
March 2011, Wiley-Blackwell
Nutrition in Epigenetics is divided into two primary parts. The first part provides key principles such as epigenetic mechanisms, developmental epigenetics, and the role of epigenetics in disease. The second part looks specifically at the application of epigenetics to the field of human nutrition. Chapters review the role of specific nutrients in modulating epigenetic status and the effect on health and disease.
Nutrition in Epigenetics is an indispensable resource for researchers, professionals and advanced students with an interest in human nutrition, epigenetics, and biomedical research.
1. Introduction (Mihai D. Niculescu and Paul Haggarty).
PART I: Fundamental Principles in Epigenetics.
SECTION A: Epigenetic Mechanisms.
2. DNA Methylation (Natalia V. Cucu).
3. Chromatin Modifications (Sandra B. Hake).
4. Roles of RNAi and Other MicroRNAs in the Regulation of Epigenetic Processes (Muller Fabbri).
5. Epigenetic Inheritance: Both Mitotic and Meiotic (Nina J. Kaminen-Ahola, Arttu I. Ahola, and Emma Whitelaw).
SECTION B: Development Epigenetics.
6. Developmental Epigenetics: Roles in Embryonic Development (Liliana Burlibaşa and Lucian Gavrilă).
SECTION C: Epigenetic Mechanisms in Disease.
7. Epigenetics, Nutrition, and Cancer (Amy R. Johnson).
8. Metabolic Syndrome, Obesity, and Diabetes (Karen D. Corbin).
9. Autoimmunity (Donna Ray and Raymond Yung).
10. Cardiovascular Diseases (Aurelian Bidulescu and Methode Bacanamwo).
PART II: Nutritional Status and Specific Nutrients.
SECTION A: Maternal Nutrition and Fetal Development.
11. Maternal Nutrition and Developmental Outcomes (Shannon L. Haley, Laurie J. Moyer-Mileur, Robert H. Lane, and Lisa A. Joss-Moore).
SECTION B: Role of Specific Nutrients.
12. Folate, Vitamin B12, and Vitamin B6 (Patrick J. Stover).
13. Dietary Choline, Betaine, Methionine, and Epigenetic Mechanisms Influencing Brain Development (Steven H. Zeisel).
14. Epigenetic Regulation by Retinoids (Amandio Vieira).
15. We are WhatWe Eat: How Nutritional Compounds Such As Isoflavones Shape Our Epigenome (Carlos M. Guerrero-Bosagna and Susan J. Clark).
16. Isothiocyanates and Polyphenols (Nigel J. Belshaw and Ian T. Johnson).
SECTION C: Macronutrient Intakes.
17. The Effect of Maternal Macronutrient Intake on Phenotype Induction and Epigenetic Gene Regulation (Karen A. Lillycrop, Mark A. Hanson, and Graham C. Burdge).
SECTION D: Environmental Exposures.
18. Epigenetic Manifestation of Environmental Exposures (Dana C. Dolinoy, Olivia S. Anderson, and Laura S. Rozek).
SECTION E: Epidemiology of Nutritional Epigenetics.
19. Epigenetics, Nutrition, and Reproduction: Short- and Long-Term Consequences (Paul Haggarty).
20. Nutrition, Epigenetics, and Cancer: An Epidemiological Perspective (Audrey Jung and Ellen Kampman).
Paul Haggarty is Head of the Lifelong Health Programme, and the Nutrition and Epigenetics Group, at the Rowett Institute of Nutrition and Health in the University of Aberdeen in Aberdeen, Scotland.