Biomarkers for Antioxidant Defense and Oxidative Damage
June 2011, Wiley-Blackwell
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Discovering sensitive and specific biomarkers for systemic oxidative damage is essential to understand the role of oxidative stress in human disease. Once these roles are clearly understood, we are able to identify novel drug and nutraceutical targets. This volume goes beyond conventional analytical methods of measuring overall antioxidant activity and provides insight to the discovery of biomarkers that reveal information on specific areas of oxidative stress. Contributed by an international list of experts, Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications describes both conventional biomarkers and recent developments in this area.
- Discusses conventional biomarkers as well as recent advances for measuring antioxidants and oxidative stress
- Biomarkers for lipid peroxidation: isoprostane, hydroxyloctadecaenoic acid, oxysterols, and reactive carbonyl species from lipid peroxidation
- Biomarkers for protein oxidation: carbonylation, tyrosine oxidation, ubiquitin-conjugation
- Biomarkers for DNA oxidative damage: comet assay, hydroxylated nucleotides, and exocylcic DNA adducts
- Recently developed biomarkers from cutting-edge technology