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Psychobiological Approaches for Anxiety Disorders: Treatment Combination Strategies

ISBN: 978-0-470-97181-9
216 pages
April 2012, Wiley-Blackwell
Psychobiological Approaches for Anxiety Disorders: Treatment Combination Strategies (0470971819) cover image
Psychobiological Approaches for Anxiety Disorders presents a comprehensive overview of the latest empirical evidence and research results on combining pharmacological agents and CBT techniques for the treatment of anxiety disorders.

  • The first book to focus on the issue of enhancing CBT with pharmacological agents
  • Features chapters from leading authors in the fields of psychiatry, pharmacology, clinical psychology, neuroscience, and emotion research
  • Contributes significantly to the field by summarizing the contemporary research in combination treatments in anxiety disorders
  • A valuable resource for clinicians in training, as well as experienced clinicians seeking to help patients with anxiety disorders
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About the Contributors  vii

About the Editor xi

Introduction  1
Stefan G. Hofmann

Chapter 1 The Biology and Efficacy of Combination Strategies for Anxiety Disorders  5
Keith A. Ganasen and Dan J. Stein

Chapter 2 Benzodiazepines  25
Bridget A. Hearon and Michael W. Otto

Chapter 3 Tricyclic Antidepressants and Monoamine Oxidase Inhibitors  41
Franklin R. Schneier

Chapter 4 Selective Serotonin Reuptake Inhibitors, Reversible Inhibitors of Monoamine Oxidase-A, and Buspirone  61
Borwin Bandelow, Markus Reitt, and Dirk Wedekind

Chapter 5 D-Cycloserine 75
Adam J. Guastella and Gail A. Alvares

Chapter 6 Yohimbine Hydrochloride  91
Samantha G. Farris, Michelle L. Davis, Lindsey B. DeBoer, Jasper A. J. Smits, and Mark B. Powers

Chapter 7 Cortisol 109
Leila Maria Soravia and Dominique J.-F. de Quervain

Chapter 8 Oxytocin 123
Markus Heinrichs, Frances S. Chen, and Gregor Domes

Chapter 9 Dietary Supplements 145
Lindsey B. DeBoer, Michelle L. Davis, Mark B. Powers, and Jasper A. J. Smits

Chapter 10 A Roadmap for the Research and Practice of Combination Strategies 181
Stefan G. Hofmann

Index 195

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Stefan G. Hofmann is Professor of Psychology at Boston University and the Director of the Psychotherapy and Emotion Research Laboratory. The incoming President of the Association for Behavioral and Cognitive Therapies, he is widely published with more than 200 peer-reviewed journal articles and book chapters, and 10 books, including An Introduction to Modern CBT (2011, Wiley-Blackwell).
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There are two major treatment approaches for anxiety and its disorders: psychological and pharmacological. But for too long these treatment approaches have been administered like ships passing in the night with little or no useful information available on when or why they should be integrated and combined. Now Stefan Hofmann in a groundbreaking edited volume gives this topic the broadest and deepest coverage it has yet enjoyed looking at current evidence and possible mechanisms of action involved in integrating not only the major compounds such as benzodiazepines and selective serotonin re-uptake inhibitors (SSRIs) with psychological treatments, but also some of the newer compounds such as D-cycloserine and oxytocin. Ending with a road map for the future, this volume should be on the shelf of every clinician and clinical investigator working on the problem of pathological anxiety.
David H. Barlow, Professor of Psychology and Psychiatry, Founder and Director Emeritus, Center for Anxiety and Related Disorders, Boston University

Internationally recognized research psychologist, Stefan Hofmann, has brought together leading experts on the neuroscience, effectiveness, and clinical use of biological treatments for the major anxiety disorders. This volume – Psychobiological Approaches for Anxiety Disorders – is a seminal book and a remarkable achievement. Each chapter provides a clear, scholarly review of the research on medications and even the use of dietary supplements in combination with CBT, or alone. This unique volume will become the standard reference for anyone seriously interested in the important question of whether combination treatments are helpful and – if they are or are not – why this is the case. A major contribution to the field, I think that all researchers and informed clinicians will want to read this book.
Robert L. Leahy, Clinical Professor of Psychology, Weill-Cornell University Medical School and Director, American Institute for Cognitive Therapy

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