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Signal Transduction and Human Disease

Toren Finkel (Editor), J. Silvio Gutkind (Editor)
ISBN: 978-0-471-02011-0
488 pages
May 2003
Signal Transduction and Human Disease (0471020117) cover image


This book uniquely relates the broad impact of signal transduction research on the understanding and treatment of human disease. There have been significant advances in the area of signaling in disease processes, yet no resource presently connects these advances with understanding of disease processes and applications for novel therapeutics. Given the emphasis on translational research and biological relevance in biotechnology, and, conversely, the importance of molecular approaches for clinical research, it is evident that a single resource bridging signaling research and human disease will be invaluable.
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Table of Contents




1. Atherosclerosis: Signal Transduction by Oxygen and Nitrogen Radicals (Jonathan M. Hill, Ilsa I. Rovira, and Toren Finkel).

2. NF-kB:A Key Signaling Pathway in Asthma (Stewart J. Levine).

3. Molecular Mechanisms of Cancer (Akrit Sodhi, Silvia Montaner, and J. Silvio Gutkind).

4. Apoptotic Pathways in Cancer Progression and Treatment (Joya Chandra and Scott H. Kaufmann).

5. Molecular and Cellular Aspects of Insulin Resistance: Implications for Diabetes (Derek Le Roith, Michael J. Quon, and Yehiel Zick).

6. Dysfunction of G Protein-Regulated Pathways and Endocrine Diseases (William F. Simonds).

7. Bacterial Regulation of the Cytoskeleton (Jeremy W. Peck, Dora C. Stylianou, and Peter D. Burbelo).

8. Bacterial Toxins and Diarrhea (Walter A. Patton, Joel Moss, and Martha Vaughan).

9. Molecular Basis of Severe Combined Immunodeficiency: Lessons from Cytokine Signaling Pathways (Roberta Visconti, Fabio Candotti, and John J. O’Shea).

10. Mast Cell-Related Diseases: Genetics, Signaling Pathways, and Novel Therapies (Michael A. Beaven and Thomas R. Hundley).

11. Rheumatology and Signal Transduction (Keith M. Hull and Daniel L. Kastner).

12. Molecular Mechanisms of Neurodegenerative Disorders (Benjamin Wolozin).

13. Neurotrophic Signaling in Mood Disorders (Jing Du,Todd D. Gould, and Husseini K. Manji).

14. Inhibiting Signaling Pathways Through Rational Drug Design (James N.Topper and Neill A. Giese).


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Author Information

Dr. Toren Finkel is Chief of the Cardiovascular Branch, National Heart Lung and Blood Institute, National Institutes of Health (NIH, DHHS). He received his undergraduate training in physics and then completed a combined M.D./Ph.D. program at Harvard Medical School. Following graduation he pursued an internal medical residency at the Massachusetts General Hospital in Boston and a Cardiology Fellowship at Johns Hopkins School of Medicine in Baltimore. His laboratory has been interested in the role of oxidants as signaling molecules and the participation of free radicals in human disease.

Dr. J. Silvio Gutkind is Chief of the Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health (NIH, DHHS). He received his Ph.D. in pharmacy and biochemistry from the University of Buenos Aires, Argentina. His laboratory has addressed the molecular basis of cancer by studying normal and aberrant functions of molecules involved in the transduction of proliferative signals. He also leads a multi-institutional effort aimed to elucidate the molecular changes that contribute to the evolution of squamous cell carcinomas.

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"The book is attractively laid out with clear, well-labeled figures and charts…" (Journal of Natural Products, March 2005)

"...the overall worth of the book is in the excellent job it does of taking readers from the etiology and management of the disease to our current understanding of the molecular mechanisms involved." (Quarterly Review of Biology, March-May 2005)

“…a successful work…serves as a short summarising overview…” (Signal Transduction, No.1 – 2, 2004)

"...appropriate for a textbook...pathways and their regulation are well explained and there are helpful tables and illustrations. The information is current and is well referenced...Finkel, Gutkind, and their coauthors have put together examples that illustrate the growing depth of understanding the roles of signal transduction in disease..." (Cell, January 9, 2004)

“...provides a sweeping look at current information derived from assessing the role of some kinases and phosphases on human conditions associated with disease...the book contains thoughtful, well-planned chapters...with extensive citations and excellent artwork...extremely valuable.” (Pharmaceutical Research, Vol. 20, No. 12, December 2003)

"[Signal Transduction and Human Disease] is the kind of monograph that can be read quickly to understand a critical area of basic biology... Very helpful in getting into the more complex literature."
—Myron L. Weisfeldt, M.D., Director, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland

"An excellent text. Well written, precise chapters that explain the interface between molecular medicine and clinical practice at a level appropriate for educated laypersons, physicians and scientists."
—Marschall S. Runge, M.D., Ph.D., Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

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