The Bioorganic Chemisty of Enzymatic Catalysis
Reactive Molecules The Neutral Reactive Intermediates in Organic Chemistry Curt Wentrup A unique, pedagogically sound text and monograph describing the formation, detection, and chemistry of neutral reactive intermediates (free radicals, diradicals, carbenes, nitrenes, strained rings, and antiaromatics). Starting from first principles, it brings the reader up-to-date on the current state of research on these intermediates. Chapters end with a problems section, with some bearing directly on the main theme of each chapter, and others extending the range of reactions covered. 1984 Enzyme Kinetics Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems Irwin H. Segel Thorough coverage of enzyme kinetics from its most elementary aspects to steady-state kinetics and isotope exchange. Offers a basic understanding of the behavior of enzyme systems and the diagnostic tools used to characterize enzymes and determine enzyme mechanisms. Explains the basis of coupled enzyme assays, regulation by "energy charge," cumulative, concerted, and cooperative feedback inhibition, and metal ion activation. 1975
About the authors Dr. Myron L. Bender has spent most of his scientific life trying to integrate organic chemistry and biochemistry. He is presently Professor of Chemistry and Biochemistry at Northwestern University in Evanston, Illinois. He has written four other books on bioorganic chemical topics. His present research is concerned with producing an organic chemical model of an acyl-chymotrypsin intermediate and synthesizing and evaluating an organic chemical model of the enzyme chymotrypsin. He is a member of the National Academy of Sciences. Dr. Raymond J. Bergeron was born March 26, 1945, in Fitchburg, Massachusetts. He received his BS from Clark University and a PhD in organic chemistry from Brandeis University under the direction of J. B. Hendrickson. He was an NIH Postdoctoral Fellow at Harvard University in Professor Conrad Bloch's Laboratories. Dr. Bergeron was an Assistant Professor at the University of Maryland where he was an Alfred P. Sloan Foundation Fellow. He then moved to the University of Florida, where he is currently a Professor in the Department of Medicinal Chemistry. He also holds joint positions in the Department of Medicine, College of Medicine, and Department of Chemistry, College of Arts and Sciences. Dr. Makoto Komiyama is Assistant Professor of Chemistry at the University of Tokyo. Among his awards is the Chemical Society of Japan Award for Young Chemists. Dr. Komiyama's research interests include cyclodextrin chemistry, functionalized polymer chemistry, and molecular complex chemistry. He received his BA and PhD degrees in chemistry from the University of Tokyo.
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