 Combinatorial Chemistry and Molecular Diversity in Drug Discovery
ISBN: 978-0-471-15518-8
Hardcover
544 pages
August 1998
US $140.95
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Partial table of contents:
COMBINATORIAL CHEMISTRY AND MOLECULAR DIVERSITY: AN INTRODUCTION.
Historical Overview of the Developing Field of Molecular Diversity (J. Chabala, et al.).
Solid-Phase Peptide Synthesis, Lead Generation, and Optimization (B. Seligman, et al.).
Oligonucleotide Libraries as a Source of Molecular Diversity (H.-Y. Mei, et al.).
SMALL MOLECULAR LIBRARIES.
Protease Inhibitor Libraries (D. Patel & D. Campbell).
Scaffolds for Small Molecule Libraries (M. Pavia).
Encoded Combinatorial Chemistry (J. Jacobs & Z.-J. Ni).
Parallel Organic Synthesis in Array Format (S. Hall).
AUTOMATION, ANALYTICAL, AND COMPUTATIONAL METHODS.
Automation of Combinatorial Chemistry for Large Libraries (M. Needels & J. Sugarman).
Quantifying Diversity (Y. Martin, et al.).
BIOLOGICAL DIVERSITY.
Protein Scaffolds for Peptide Libraries (R. Hoess).
SCREENING.
Strategies for Screening Combinatorial Libraries (B. Beutel).
COMBINATORIAL DRUG SCREENING AND DEVELOPMENT.
Combinatorial Technologies: Prospects and Future Issues (J. Kerwin).
Appendix.
Index.
COMBINATORIAL CHEMISTRY AND MOLECULAR DIVERSITY: AN INTRODUCTION.
Historical Overview of the Developing Field of Molecular Diversity (J. Chabala, et al.).
Solid-Phase Peptide Synthesis, Lead Generation, and Optimization (B. Seligman, et al.).
Oligonucleotide Libraries as a Source of Molecular Diversity (H.-Y. Mei, et al.).
SMALL MOLECULAR LIBRARIES.
Protease Inhibitor Libraries (D. Patel & D. Campbell).
Scaffolds for Small Molecule Libraries (M. Pavia).
Encoded Combinatorial Chemistry (J. Jacobs & Z.-J. Ni).
Parallel Organic Synthesis in Array Format (S. Hall).
AUTOMATION, ANALYTICAL, AND COMPUTATIONAL METHODS.
Automation of Combinatorial Chemistry for Large Libraries (M. Needels & J. Sugarman).
Quantifying Diversity (Y. Martin, et al.).
BIOLOGICAL DIVERSITY.
Protein Scaffolds for Peptide Libraries (R. Hoess).
SCREENING.
Strategies for Screening Combinatorial Libraries (B. Beutel).
COMBINATORIAL DRUG SCREENING AND DEVELOPMENT.
Combinatorial Technologies: Prospects and Future Issues (J. Kerwin).
Appendix.
Index.
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