 Amiloride and Its Analogs: Unique Cation Transport Inhibitors
ISBN: 978-0-471-18794-3
Hardcover
388 pages
December 1992
US $275.00
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Contributors
Section A Introduction
1. Historical Perspective
Edward J. Cragoe, Jr.
2. An Overview of the Structure-Activity Relations in the Amiloride Series
Louis Simchowitz, Thomas R. Kleyman, and Edward J. Cragoe, Jr.
3. The Synthesis of Amiloride and Its Analogs
Edward J. Cragoe, Jr.
Section B Transport Systems Affected by Amiloride Analogs
4. Amiloride-Sensitive Sodium Channels
Young S. Oh and Dale J. Benos
5. Na+/H+ Exchange in Epithelia
Robert F. Reilly and Peter S. Aronson
6. Na+/H+ Exchange in Blood Cells
William E. Dale and Louis Simchowitz
7. Na+/H+ Exchange in an Excitable Tissue
Peter J. Little
8. Na+/Ca2+ Exchange
Gregory J. Kaczorowski
9. Voltage-Dependent Ca2+ Channels
Gregory J. Kaczorowski and Maria L. Garcia
10. Inhibition of Sodium-Dependent Solute Cotransport in Renal Brush Border Membrane Vesicles by Amiloride
Julian L. Seifter, Robert A. Lufburrow III, and Raymond C. Harris
11. Cellular Systems: Enzymes, Receptors, and Metabolic Pathways
Jeffrey M. Besterman
Section C Biologic Applications and Immunologic Approaches
12. Radiolabeled Analogs
Paul Vigne and Christian Frelin
13. Photoreactive Amiloride Analogs
Chaomei Lin and Thomas R. Kleyman
14. Generation, Characterization, and Utilization of Anti-Amiloride Antibodies
Thomas R. Kleyman
15. Generation of Antibodies Directed Against the Amiloride-Binding Site on Specific Transport Proteins by an Antiidiotypic Approach
Brigitte Coupaye-Gerard and Thomas R. Kleyman
Section D Molecular Biology
16. Molecular Organization of the Human Amiloride-Sensitive Na+/H+ Antiporter Gene
Gilles Pagès, Claude Sardet, and Jacques Pouysségur
17. Molecular Biology of the Na+/H+ Exchanger Amiloride-Binding Site
Laurent Counillon, Claude Sardet, and Jacques Pouysségur
Section E Clinical Applications
18. K+ Sparing Diuretics
George M. Feldman and Krystyna Drewnowska
19. Antihypertensive Agents
Francis J. Haddy and Motilal B. Pamnani
20. Amiloride in Cystic Fibrosis: Safety, Pharmacokinetics, and Efficacy in the Treatment of Pulmonary Disease
Michael R. Knowles, Nina L. Church, William E. Waltner, John T. Gatzy, and Richard C. Boucher
21. The Use of Na+/H+ Antiporter Inhibitors as a Novel Approach to Cancer Treatment
Salvador Harguindey
22. Other Potential Medical Uses and Summary
Edward J. Cragoe, Jr.
Index
Section A Introduction
1. Historical Perspective
Edward J. Cragoe, Jr.
2. An Overview of the Structure-Activity Relations in the Amiloride Series
Louis Simchowitz, Thomas R. Kleyman, and Edward J. Cragoe, Jr.
3. The Synthesis of Amiloride and Its Analogs
Edward J. Cragoe, Jr.
Section B Transport Systems Affected by Amiloride Analogs
4. Amiloride-Sensitive Sodium Channels
Young S. Oh and Dale J. Benos
5. Na+/H+ Exchange in Epithelia
Robert F. Reilly and Peter S. Aronson
6. Na+/H+ Exchange in Blood Cells
William E. Dale and Louis Simchowitz
7. Na+/H+ Exchange in an Excitable Tissue
Peter J. Little
8. Na+/Ca2+ Exchange
Gregory J. Kaczorowski
9. Voltage-Dependent Ca2+ Channels
Gregory J. Kaczorowski and Maria L. Garcia
10. Inhibition of Sodium-Dependent Solute Cotransport in Renal Brush Border Membrane Vesicles by Amiloride
Julian L. Seifter, Robert A. Lufburrow III, and Raymond C. Harris
11. Cellular Systems: Enzymes, Receptors, and Metabolic Pathways
Jeffrey M. Besterman
Section C Biologic Applications and Immunologic Approaches
12. Radiolabeled Analogs
Paul Vigne and Christian Frelin
13. Photoreactive Amiloride Analogs
Chaomei Lin and Thomas R. Kleyman
14. Generation, Characterization, and Utilization of Anti-Amiloride Antibodies
Thomas R. Kleyman
15. Generation of Antibodies Directed Against the Amiloride-Binding Site on Specific Transport Proteins by an Antiidiotypic Approach
Brigitte Coupaye-Gerard and Thomas R. Kleyman
Section D Molecular Biology
16. Molecular Organization of the Human Amiloride-Sensitive Na+/H+ Antiporter Gene
Gilles Pagès, Claude Sardet, and Jacques Pouysségur
17. Molecular Biology of the Na+/H+ Exchanger Amiloride-Binding Site
Laurent Counillon, Claude Sardet, and Jacques Pouysségur
Section E Clinical Applications
18. K+ Sparing Diuretics
George M. Feldman and Krystyna Drewnowska
19. Antihypertensive Agents
Francis J. Haddy and Motilal B. Pamnani
20. Amiloride in Cystic Fibrosis: Safety, Pharmacokinetics, and Efficacy in the Treatment of Pulmonary Disease
Michael R. Knowles, Nina L. Church, William E. Waltner, John T. Gatzy, and Richard C. Boucher
21. The Use of Na+/H+ Antiporter Inhibitors as a Novel Approach to Cancer Treatment
Salvador Harguindey
22. Other Potential Medical Uses and Summary
Edward J. Cragoe, Jr.
Index
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