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When Cells Die II: A Comprehensive Evaluation of Apoptosis and Programmed Cell Death

Richard A. Lockshin (Editor), Zahra Zakeri (Editor)
ISBN: 978-0-471-21947-7
572 pages
December 2003
When Cells Die II: A Comprehensive Evaluation of Apoptosis and Programmed Cell Death (0471219479) cover image
Cell death is fast becoming one of the most dynamic areas of biological research-involving as it does the study of apoptosis and programmed cell death and the role these phenomena play in development and homeostasis on the one hand, and aging and disease on the other. The profound implications for medicine and agriculture from the manipulation of these processes have spawned a deluge of research papers, articles, approaches, and methods-making it difficult for scientists to get an overview of the field.
When Cells Die II: A Comprehensive Evaluation of Apoptosis and Programmed Cell Death offers the most thorough, cutting-edge coverage of this field since publication of the acclaimed first edition. Leading international researchers present an up-to-date yet accessible survey ranging from the history of cell death science to its modern methodology. Extensively revised to include major advances in research, this new edition features relevant discussion of:
* The impact of genomics and proteomics
* Gene therapy and pharmacogenetics
* The role of mitochondria
* Caspase-independent and non-apoptotic cell death
* Evolution of mechanisms
With the manipulation of programmed cell death in clinical situations now in the foreseeable future, When Cells Die II also addresses the role of apoptosis in specific organ systems-the immune system, nervous system, and gastrointestinal tract-as well as different disease states, including viral infection, cancer, and myocardial infarct.
Expertly edited to provide detailed cross-referencing, consistency of style, and a logical progression of topics, When Cells Die II is the definitive resource for understanding current cell death science. It will prove an invaluable text for advanced undergraduate, graduate, and medical students, postdoctoral fellows, scientists, and clinicians in cell biology, immunology, developmental biology, neuroscience, and cancer research.
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CONTRIBUTORS, VII

PREFACE, XI

SECTION I CELL DEATH ORIGIN AND PROGRESSION

1 INTRODUCTION, 3
Richard A. Lockshin and Zahra Zakeri

SECTION II BIOLOGICAL ROLE OF CELL DEATH IN DEVELOPMENT AND HOMEOSTASIS

2 CELL DEATH: SHAPING AN EMBRYO, 27
Zahra Zakeri and Richard A. Lockshin

3 CELL DEATH IN DICTYOSTELIUM: ASSESSING A GENETIC APPROACH, 59
Jean-Pierre Levraud, Myriam Adam, Marie-Françoise Luciani, Laurence Aubry, Gérard Klein, and Pierre Golstein

4 PROGRAMMED CELL DEATH IN DROSOPHILA MELANOGASTER, 79
Loretta Dorstyn and Sharad Kumar

5 CELL DEATH IN PLANT DEVELOPMENT AND DEFENSE, 99
Ron Mittler and Alice Y. Cheung

6 REGULATION OF APOPTOSIS BY EXTRACELLULAR MATRIX DURING POSTEMBRYONIC DEVELOPMENT IN XENOPUS LAEVIS, 123
Atsuko Ishizuya-Oka, Tosikazu Amano, Liezhen Fu, and Yun-Bo Shi

7 APOPTOSIS IN THE IMMUNE SYSTEM, 143
Alexandra Brás, David García-Domingo, and Carlos Martinez-A.

8 CELL DEATH IN NEURONAL DEVELOPMENT AND MAINTENANCE, 175
Aviva M. Tolkovsky, Edward T. W. Bampton, and Cristoph G. Goemans

9 CELL TURNOVER: INTESTINE AND OTHER TISSUES, 201
James W. Wilson and Christopher S. Potten

10 CELL DEATH, AGING PHENOTYPES, AND MODELS OF PREMATURE AGING, 241
Huber R. Warner

SECTION III HOW CELL DEATH IS CARRIED OUT

11 SURVIVAL FACTORS, 257
David L. Vaux

12 CASPASE-INDEPENDENT AND AUTOPHAGIC PROGRAMMED CELL DEATH, 275
Wilfried Bursch, Adolf Ellinger, Christopher Gerner, and Rolf Schulte-Hermann

13 THE RECOGNITION AND ENGULFMENT OF APOPTOTIC CELLS BY PHAGOCYTES, 311
Raymond B. Birge

14 CELL CYCLE GENES: pRb AND p53, 339
Nianli Sang and Antonio Giordano

15 MITOCHONDRIA AND OXIDATION IN THE REGULATION OF CELL DEATH, 381
John D. Robertson, Sten Orrenius, and Boris Zhivotovsky

SECTION IV DEREGULATION OF CELL DEATH IN DISEASE AND FUTURE INTERVENTION

16 THE USE OF PROTEOMICS TO IDENTIFY AND CHARACTERIZE CELL DEATH PROTEINS, 405
Xavier Saelens, Geert van Loo, Kris Gevaert, Joel Vanderkerckhove, and Peter Vandenabeele

17 CELL DEATH IN VIRAL INFECTIONS, 435
Ying-bei Chen, Yihru Fannjiang, and J. Marie Hardwick

18 CELL DEATH IN CANCER AND CANCER THERAPY, 461
Simone Fulda and Klaus-Michael Debatin

19 THE ROLE OF APOPTOSIS IN MYOCARDIAL INFARCTION AND HEART FAILURE, 483
Kartik Mani, Chang-Fu Peng, Gregg Rosner, and Richard N. Kitsis

INDEX, 521

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"...thoughtfully edited and readable. The book illustrates the importance of apoptosis in development, homeostasis, and human disease...an important contribution to the literature." (Doody's Book Review Service)

"…thoroughly researched, highly readable, and informative." (E-STREAMS, March 2005)

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