DANIEL LEDNICER has devoted his career in both the private and public sectors to the search for new therapeutic agents. A former chemist and project officer at the National Cancer Institute, he has held the positions of director of chemical research at Mead Johnson, director of pharmaceutical sciences at Adria Laboratories, and pharmaceutical manager at Analytical Biochemistry Laboratories. He is the author or coauthor of the five previous volumes in the Wiley series, The Organic Chemistry of Drug Synthesis, and author of the recent book, Strategies for Organic Drug Synthesis and Design, also published by Wiley.