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The Nuclear Overhauser Effect in Structural and Conformational Analysis, 2nd Edition

ISBN: 978-0-471-24675-6
656 pages
April 2000
The Nuclear Overhauser Effect in Structural and Conformational Analysis, 2nd Edition (0471246751) cover image

Description

An authoritative review of the state of the art in the Nuclear Overhauser Effect-essential information for organic chemists, biochemists, biophysicists, and NMR spectroscopists
The field of NMR spectroscopy has seen tremendous growth in the last twenty years, particularly advances relating to Nuclear Overhauser Effect (NOE) spectroscopy-the most powerful technique for obtaining structural information on molecules in solution. Extensive and engaging, the Second Edition of the leading reference on the NOE is significantly updated to reflect the latest changes and new approaches in the field.
Neuhaus and Williamson provide an essential guide to the complexities and use of the NOE in a readily accessible, straightforward manner. Their practical handbook features a new chapter addressing the use of NOE data to calculate biomolecular structures. Chapters dealing with the kinetics of the NOE, the effects of exchange and internal motion, and applications of the NOE, are also extensively revised. Cross-referenced in remarkable depth, The Nuclear Overhauser Effect is organized into three main parts:
* Part I describes the theory of the Nuclear Overhauser Effect in a clear, comprehensive fashion
* Part II discusses the considerations involved in implementing NOE experiments, including full coverage of all necessary details for both new and established techniques
* Part III offers examples of how the NOE is used, including applications to defining molecular geometry, stereochemistry, conformation, and biomolecular structure and interactions
The Nuclear Overhauser Effect in Structural and Conformational Analysis, Second Edition, uniquely explains the NOE in detail, making it an indispensable resource for the novice as well as the experienced NMR researcher.
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Table of Contents

THEORY.

Background.

The Steady-State NOE for Two Spins.

The Steady-State NOE in Rigid Multispin Systems.

The Kinetics of the NOE.

The Effects of Exchange and Internal Motion.

Complications from Spin-Spin Coupling.

EXPERIMENTAL.

One-Dimensional Experiments.

The Two-Dimensional NOESY Experiment.

Other Developments.

APPLICATIONS.

Applications of the NOE to Structure Elucidation.

Applications of the NOE to Conformational Analysis.

Calculating Structures of Biopolymers.

Biopolymers.

Appendices.

Index.
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Author Information

DAVID NEUHAUS, PhD, is Staff Scientist heading the NMR Group at the M.R.C. Laboratory of Molecular Biology, Cambridge, United Kingdom.

MICHAEL P. WILLIAMSON, PhD, is a Reader at the University of Sheffield, United Kingdom.
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Reviews

"Describes the theory of the nuclear Overhauser effect, discusses the considerations involved in implementing NOE experiments, and offers examples..." (SciTech Book News, Vol. 24, No. 4, December 2000)
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