Toxicology of the Immune System: A Human Approach
- Organ systems and target cells most often affected
- Types of damage and injury resulting from immunotoxic reactions
- Clinical populations in which immune system damage occurs
- Methods for investigating the etiology of agents and risk assessment
- Relevance of laboratory data to human risk
- Strategies for achieving standard practices to prevent the disparity in results that characterizes many immune system studies
- Regulatory affairs related to immunotoxicology
Laboratory and experimental findings are probed to determine how and to what degree different immunotoxicants have induced clinical disease. Citations of animal research are restricted to those studies that point the way for future human studies, or have direct relevance to human situations. To further the reader’s understanding of xenobiotics, the authors treat the subject of purposeful immunomodulation, achieved by administering immunosuppressive or immunopotentiating drugs. Despite increasing public awareness, there remains an inaccurate perception of what chemicals can and cannot do. This important reference sets the record straight, making it an essential source for toxicologists, immunologists, industrial hygienists, microbiologists, allergists, as well as all professionals in the agricultural and cosmetic industries, and those involved in chemical and biological regulation.
Basic Principles of Toxicology.
Effector Mechanisms: Immunopharmacology.
Effector Mechanisms: Expression of Immunity.
Mechanisms of Injury by the Immune System.
Damage to the Immune System.
Intentional Modulation of the Immune Response: Immunopotentiation and Immunosuppression.
Assessment of Secondary Immunodeficiencies in Man and Animals.
Relevance of Immunotoxicologic Findings to Human Immune Competence.
Agents and Effects of Immunotoxicity.