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Immunology: Clinical Case Studies and Disease Pathophysiology

ISBN: 978-0-471-32659-5
424 pages
March 2009, Wiley-Blackwell
Immunology: Clinical Case Studies and Disease Pathophysiology (0471326593) cover image
  • 26 real-life cases illustrate the applications of basic immunology in clinical settings
  • May be utilized alone or as a companion to Immunology: A Short Course 6th edition by Coico and Sunshine ISBN 9780470081587
  • Each case study is introduced by clearly written descriptions of the major immunological disorders
  • Full colour photographs and illustrations complement complete presentation of real data
  • Includes complete set of problems and discussion questions for each chapter
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Preface, ix

Contributors, xi

Index of Lessons in Normal Immunity, xiii

INTRODUCTION TO CASE STUDIES: A GUIDE TO USING THIS BOOK, 1

Unit I IMMUNODEFICIENCY DISEASES, 3

INTRODUCTION: ORGANIZATION OF THE IMMUNE SYSTEM AND EVALUATION OF THE IMMUNODEFICIENT PATIENT, 5

1 X-LINKED AGAMMAGLOBULINEMIA (BRUTON’S AGAMMAGLOBULINEMIA), 15

2 SEVERE COMBINED IMMUNODEFICIENCY DISEASE, 27

3 DiGEORGE SYNDROME (CONGENITAL THYMIC APLASIA), 41

4 HYPER-IgM SYNDROME, 53

5 COMMON VARIABLE IMMUNODEFICIENCY DISEASE, 67

6 AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME (ALPS), 81

7 X-LINKED LYMPHOPROLIFERATIVE SYNDROME, 91

8 HEREDITARY ANGIOEDEMA, 101

9 ACQUIRED IMMUNODEFICIENCY SYNDROME, 111

Unit II IMMEDIATE HYPERSENSITIVITY AND MAST CELL DISORDERS, 125

INTRODUCTION: WHEN ANTIGENS BECOME ALLERGENS, 127

10 MASTOCYTOSIS, 129

11 ANAPHYLAXIS, 137

12 ASTHMA, 147

13 THE VASCULITIDES, 161

Unit III AUTOIMMUNE DISORDERS, 173

INTRODUCTION: OVERVIEW OF AUTOIMMUNE DISORDERS AND MECHANISMS OF TOLERANCE, 175

14 MYASTHENIA GRAVIS, 183

15 MULTIPLE SCLEROSIS, 195

16 DIABETES MELLITUS TYPE 1, 207

17 CELIAC DISEASE, 219

18 INFLAMMATORY BOWEL DISEASE, 231

19 PSORIASIS, 245

20 IgA NEPHROPATHY AND KIDNEY TRANSPLANTATION, 255

21 RHEUMATOID ARTHRITIS, 269

22 SYSTEMIC LUPUS ERYTHEMATOSUS, 283

23 SCLERODERMA, 299

Unit IV MALIGNANCIES OF THE LYMPHOID SYSTEM, 309

INTRODUCTION: CLASSIFICATION OF LYMPHOID MALIGNANCIES, 311

24 CHRONIC LYMPHOCYTIC LEUKEMIA/SMALL LYMPHOCYTIC LYMPHOMA, 317

25 FOLLICULAR LYMPHOMA, 327

26 PLASMA CELL NEOPLASMS, 337

Unit V 349

LABORATORY TESTS USED IN THE WORKUP OF PATIENTS WITH IMMUNOLOGIC DISEASES, 351

Index, 369

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Warren Strober, M.D., is Section Chief in the Laboratory of Clinical Investigation, Mucosal Immunity Section at the National Institute of Allergy and Infectious Diseases, National Institutes of Health.

Susan R.S. Gottesman, M.D., Ph.D., is Associate Professor in the Department of Pathology at SUNY Health Science Center at Brooklyn.

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  • Twenty-six case studies that cover topics including immunodeficiency diseases, immediate hyper-sensitivity and mast cell disorders, autoimmune disorders, and malignancies of the lymphoid system
  • Full-color photographs and illustrations that complement the case studies
  • Each section begins with an introductory chapter that teaches students about the subject area in that section, how to approach and use the material in the cases, and how to get the most out of the material for research, clinical application, and further study
  • A complete set of problems and discussion questions for each chapter
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"In all, while written as a clinically-relevant companion for an immunology text, this book can stand alone as a wonderful resource for any clinical immunologist and can serve as an excellent teaching aid for anyone studying immunology or training in a field that cares for patients with immune disorders." (The World Allergy Organization, 1 August 2011)

“[This book] effectively accomplishes its stated goals. This well-written and easy-to-read book covers a wide variety of topics … and provides a wealth of experience in a patient-oriented format. The editors of this book succeed in moving readers from beginning to end using this case-based approach. [This book] offers a number of teaching possibilities and could be useful in teaching immunology when combined with current textbooks.” (JAMA, April 2010)

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